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Results: 1 to 20 of 104

1.

A novel pharmacophore model to identify leads for simultaneous inhibition of anti-coagulation and anti-inflammatory activities of snake venom phospholipase A(2).

Wadood A, Ali SA, Sattar R, Lodhi MA, Ul-Haq Z.

Chem Biol Drug Des. 2012 Apr;79(4):431-41. doi: 10.1111/j.1747-0285.2011.01281.x. Epub 2012 Jan 30.

PMID:
22136624
[PubMed - indexed for MEDLINE]
2.

In silico identification of novel inhibitors against Plasmodium falciparum dihydroorate dehydrogenase.

Wadood A, Ulhaq ZU.

J Mol Graph Model. 2013 Mar;40:40-7. doi: 10.1016/j.jmgm.2012.11.010. Epub 2012 Dec 20.

PMID:
23353582
[PubMed - indexed for MEDLINE]
3.

Simultaneous inhibition of anti-coagulation and inflammation: crystal structure of phospholipase A2 complexed with indomethacin at 1.4 A resolution reveals the presence of the new common ligand-binding site.

Singh N, Kumar RP, Kumar S, Sharma S, Mir R, Kaur P, Srinivasan A, Singh TP.

J Mol Recognit. 2009 Nov-Dec;22(6):437-45. doi: 10.1002/jmr.960.

PMID:
19462410
[PubMed - indexed for MEDLINE]
4.

Structural and pharmacological features of phospholipases A2 from snake venoms.

de Paula RC, Castro HC, Rodrigues CR, Melo PA, Fuly AL.

Protein Pept Lett. 2009;16(8):899-907. Review.

PMID:
19689416
[PubMed - indexed for MEDLINE]
5.

Computer-aided drug design of novel PLA2 inhibitor candidates for treatment of snakebite.

Hage-Melim LI, da Silva CH, Semighini EP, Taft CA, Sampaio SV.

J Biomol Struct Dyn. 2009 Aug;27(1):27-36.

PMID:
19492860
[PubMed - indexed for MEDLINE]
6.

A combination of receptor-based pharmacophore modeling & QM techniques for identification of human chymase inhibitors.

Arooj M, Sakkiah S, Kim S, Arulalapperumal V, Lee KW.

PLoS One. 2013 Apr 26;8(4):e63030. doi: 10.1371/journal.pone.0063030. Print 2013.

PMID:
23658661
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Snake venom phospholipase A2 inhibitors: medicinal chemistry and therapeutic potential.

Marcussi S, Sant'Ana CD, Oliveira CZ, Rueda AQ, Menaldo DL, Beleboni RO, Stabeli RG, Giglio JR, Fontes MR, Soares AM.

Curr Top Med Chem. 2007;7(8):743-56. Review.

PMID:
17456038
[PubMed - indexed for MEDLINE]
8.

Venom neutralization by purified bioactive molecules: Synthetic peptide derivatives of the endogenous PLA(2) inhibitory protein PIP (a mini-review).

Thwin MM, Samy RP, Satyanarayanajois SD, Gopalakrishnakone P.

Toxicon. 2010 Dec 15;56(7):1275-83. doi: 10.1016/j.toxicon.2009.12.023. Epub 2010 Jan 4. Review.

PMID:
20045432
[PubMed - indexed for MEDLINE]
9.

Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties.

Soares AM, Giglio JR.

Toxicon. 2003 Dec 15;42(8):855-68. Review.

PMID:
15019487
[PubMed - indexed for MEDLINE]
10.

Design of fructose-2,6-bisphosphatase inhibitors: a novel virtual screening approach.

Shaikh MS, Mittal A, Bharatam PV.

J Mol Graph Model. 2008 Feb;26(6):900-6. Epub 2007 Jun 20.

PMID:
17644015
[PubMed - indexed for MEDLINE]
11.

Molecular docking studies and anti-enzymatic activities of Thai mango seed kernel extract against snake venoms.

Leanpolchareanchai J, Pithayanukul P, Bavovada R, Saparpakorn P.

Molecules. 2009 Mar 31;14(4):1404-22. doi: 10.3390/molecules14041404.

PMID:
19384272
[PubMed - indexed for MEDLINE]
Free Article
12.

Catalytically inactive phospholipase A2 homologue binds to vascular endothelial growth factor receptor-2 via a C-terminal loop region.

Fujisawa D, Yamazaki Y, Lomonte B, Morita T.

Biochem J. 2008 May 1;411(3):515-22. doi: 10.1042/BJ20080078.

PMID:
18251716
[PubMed - indexed for MEDLINE]
Free Article
13.

A model to explain the pharmacological effects of snake venom phospholipases A2.

Kini RM, Evans HJ.

Toxicon. 1989;27(6):613-35. Review.

PMID:
2665186
[PubMed - indexed for MEDLINE]
14.

Simplified receptor based pharmacophore approach to retrieve potent PTP-LAR inhibitors using apoenzyme.

Ajay D, Sobhia ME.

Curr Comput Aided Drug Des. 2011 Sep 1;7(3):159-72.

PMID:
21726194
[PubMed - indexed for MEDLINE]
15.

Rosmarinic acid, a new snake venom phospholipase A2 inhibitor from Cordia verbenacea (Boraginaceae): antiserum action potentiation and molecular interaction.

Ticli FK, Hage LI, Cambraia RS, Pereira PS, Magro AJ, Fontes MR, Stábeli RG, Giglio JR, França SC, Soares AM, Sampaio SV.

Toxicon. 2005 Sep 1;46(3):318-27.

PMID:
15992846
[PubMed - indexed for MEDLINE]
16.

A phospholipase A2 with anticoagulant activity. II. Inhibition of the phospholiped activity in coagulation.

Boffa MC, Boffa GA.

Biochim Biophys Acta. 1976 May 13;429(3):839-52.

PMID:
5143
[PubMed - indexed for MEDLINE]
17.

Multiple pharmacophore models combined with molecular docking: a reliable way for efficiently identifying novel PDE4 inhibitors with high structural diversity.

Chen Z, Tian G, Wang Z, Jiang H, Shen J, Zhu W.

J Chem Inf Model. 2010 Apr 26;50(4):615-25. doi: 10.1021/ci9004173.

PMID:
20353193
[PubMed - indexed for MEDLINE]
18.

Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes.

Kini RM.

Toxicon. 2003 Dec 15;42(8):827-40. Review.

PMID:
15019485
[PubMed - indexed for MEDLINE]
19.

Biological properties of the venom of the Papuan black snake (Pseudechis papuanus): presence of a phospholipase A2 platelet inhibitor.

Kamiguti AS, Laing GD, Lowe GM, Zuzel M, Warrell DA, Theakston RD.

Toxicon. 1994 Aug;32(8):915-25.

PMID:
7985196
[PubMed - indexed for MEDLINE]
20.

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.

Kang TS, Georgieva D, Genov N, Murakami MT, Sinha M, Kumar RP, Kaur P, Kumar S, Dey S, Sharma S, Vrielink A, Betzel C, Takeda S, Arni RK, Singh TP, Kini RM.

FEBS J. 2011 Dec;278(23):4544-76. doi: 10.1111/j.1742-4658.2011.08115.x. Epub 2011 May 17. Review.

PMID:
21470368
[PubMed - indexed for MEDLINE]

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