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Results: 1 to 20 of 112

1.

Computational studies of bacterial resistance to β-lactam antibiotics: mechanism of covalent inhibition of the penicillin-binding protein 2a (PBP2a).

My NH, Hirao H, Van DU, Morokuma K.

J Chem Inf Model. 2011 Dec 27;51(12):3226-34. doi: 10.1021/ci2004175. Epub 2011 Nov 30.

PMID:
22129432
[PubMed - indexed for MEDLINE]
2.

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.

Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16808-13. doi: 10.1073/pnas.1300118110. Epub 2013 Oct 1.

PMID:
24085846
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The basis for resistance to beta-lactam antibiotics by penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus.

Fuda C, Suvorov M, Vakulenko SB, Mobashery S.

J Biol Chem. 2004 Sep 24;279(39):40802-6. Epub 2004 Jun 28.

PMID:
15226303
[PubMed - indexed for MEDLINE]
Free Article
4.

Penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus: kinetic characterization of its interactions with beta-lactams using electrospray mass spectrometry.

Lu WP, Sun Y, Bauer MD, Paule S, Koenigs PM, Kraft WG.

Biochemistry. 1999 May 18;38(20):6537-46.

PMID:
10350472
[PubMed - indexed for MEDLINE]
5.
6.

Microtiter plate-based assay for inhibitors of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus.

Bobba S, Ponnaluri VK, Mukherji M, Gutheil WG.

Antimicrob Agents Chemother. 2011 Jun;55(6):2783-7. doi: 10.1128/AAC.01327-10. Epub 2011 Mar 14.

PMID:
21402836
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus.

Fuda C, Hesek D, Lee M, Heilmayer W, Novak R, Vakulenko SB, Mobashery S.

J Biol Chem. 2006 Apr 14;281(15):10035-41. Epub 2006 Feb 3.

PMID:
16459335
[PubMed - indexed for MEDLINE]
Free Article
8.

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics.

Villegas-Estrada A, Lee M, Hesek D, Vakulenko SB, Mobashery S.

J Am Chem Soc. 2008 Jul 23;130(29):9212-3. doi: 10.1021/ja8029448. Epub 2008 Jun 27.

PMID:
18582062
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus.

Lim D, Strynadka NC.

Nat Struct Biol. 2002 Nov;9(11):870-6.

PMID:
12389036
[PubMed - indexed for MEDLINE]
10.

X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction.

Birck C, Cha JY, Cross J, Schulze-Briese C, Meroueh SO, Schlegel HB, Mobashery S, Samama JP.

J Am Chem Soc. 2004 Nov 3;126(43):13945-7.

PMID:
15506754
[PubMed - indexed for MEDLINE]
11.

Diversity of penicillin-binding proteins. Resistance factor FmtA of Staphylococcus aureus.

Fan X, Liu Y, Smith D, Konermann L, Siu KW, Golemi-Kotra D.

J Biol Chem. 2007 Nov 30;282(48):35143-52. Epub 2007 Oct 9.

PMID:
17925392
[PubMed - indexed for MEDLINE]
Free Article
12.

Specific interaction between beta-lactams and soluble penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus: development of a chromogenic assay.

Roychoudhury S, Kaiser RE, Brems DN, Yeh WK.

Antimicrob Agents Chemother. 1996 Sep;40(9):2075-9.

PMID:
8878584
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Unbound and acylated structures of the MecR1 extracellular antibiotic-sensor domain provide insights into the signal-transduction system that triggers methicillin resistance.

Marrero A, Mallorquí-Fernández G, Guevara T, García-Castellanos R, Gomis-Rüth FX.

J Mol Biol. 2006 Aug 18;361(3):506-21. Epub 2006 Jul 7.

PMID:
16846613
[PubMed - indexed for MEDLINE]
14.

Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole.

Lovering AL, Gretes MC, Safadi SS, Danel F, de Castro L, Page MG, Strynadka NC.

J Biol Chem. 2012 Sep 14;287(38):32096-102. doi: 10.1074/jbc.M112.355644. Epub 2012 Jul 19.

PMID:
22815485
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Soluble penicillin-binding protein 2a: beta-lactam binding and inhibition by non-beta-lactams using a 96-well format.

Toney JH, Hammond GG, Leiting B, Pryor KD, Wu JK, Cuca GC, Pompliano DL.

Anal Biochem. 1998 Jan 1;255(1):113-9.

PMID:
9448849
[PubMed - indexed for MEDLINE]
16.

Structure-guided design of cell wall biosynthesis inhibitors that overcome β-lactam resistance in Staphylococcus aureus (MRSA).

Contreras-Martel C, Amoroso A, Woon EC, Zervosen A, Inglis S, Martins A, Verlaine O, Rydzik AM, Job V, Luxen A, Joris B, Schofield CJ, Dessen A.

ACS Chem Biol. 2011 Sep 16;6(9):943-51. doi: 10.1021/cb2001846. Epub 2011 Aug 3.

PMID:
21732689
[PubMed - indexed for MEDLINE]
17.

Antistaphylococcal activity of the novel cephalosporin CB-181963 (CAB-175).

Miller K, Storey C, Stubbings WJ, Hoyle AM, Hobbs JK, Chopra I.

J Antimicrob Chemother. 2005 Apr;55(4):579-82. Epub 2005 Feb 18.

PMID:
15722396
[PubMed - indexed for MEDLINE]
Free Article
18.
19.

On the transcriptional regulation of methicillin resistance: MecI repressor in complex with its operator.

García-Castellanos R, Mallorquí-Fernández G, Marrero A, Potempa J, Coll M, Gomis-Rüth FX.

J Biol Chem. 2004 Apr 23;279(17):17888-96. Epub 2004 Feb 11.

PMID:
14960592
[PubMed - indexed for MEDLINE]
Free Article
20.

Insertion of epicatechin gallate into the cytoplasmic membrane of methicillin-resistant Staphylococcus aureus disrupts penicillin-binding protein (PBP) 2a-mediated beta-lactam resistance by delocalizing PBP2.

Bernal P, Lemaire S, Pinho MG, Mobashery S, Hinds J, Taylor PW.

J Biol Chem. 2010 Jul 30;285(31):24055-65. doi: 10.1074/jbc.M110.114793. Epub 2010 Jun 1.

PMID:
20516078
[PubMed - indexed for MEDLINE]
Free PMC Article

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