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Items: 1 to 20 of 139

1.

Studies toward novel peptidomimetic inhibitors of thioredoxin-thioredoxin reductase system.

Kłossowski S, Muchowicz A, Firczuk M, Swiech M, Redzej A, Golab J, Ostaszewski R.

J Med Chem. 2012 Jan 12;55(1):55-67. doi: 10.1021/jm201359d. Epub 2011 Dec 20.

PMID:
22128876
2.

Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy.

Tonissen KF, Di Trapani G.

Mol Nutr Food Res. 2009 Jan;53(1):87-103. doi: 10.1002/mnfr.200700492. Review.

PMID:
18979503
3.

Molecular bases of thioredoxin and thioredoxin reductase-mediated prooxidant actions of (-)-epigallocatechin-3-gallate.

Zhang H, Cao D, Cui W, Ji M, Qian X, Zhong L.

Free Radic Biol Med. 2010 Dec 15;49(12):2010-8. doi: 10.1016/j.freeradbiomed.2010.09.031. Epub 2010 Oct 14.

PMID:
20951799
4.

A thioredoxin reductase and/or thioredoxin system-based mechanism for antioxidant effects of ambroxol.

Huang J, Xu J, Tian L, Zhong L.

Biochimie. 2014 Feb;97:92-103. doi: 10.1016/j.biochi.2013.09.024. Epub 2013 Oct 5.

PMID:
24103200
5.

Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase.

Hashemy SI, Ungerstedt JS, Zahedi Avval F, Holmgren A.

J Biol Chem. 2006 Apr 21;281(16):10691-7. Epub 2006 Feb 14.

6.

Thioredoxin system modulation by plant and fungal secondary metabolites.

Dal Piaz F, Braca A, Belisario MA, De Tommasi N.

Curr Med Chem. 2010;17(5):479-94. Review.

PMID:
19941471
7.

Natural product based inhibitors of the thioredoxin-thioredoxin reductase system.

Wipf P, Lynch SM, Birmingham A, Tamayo G, Jiménez A, Campos N, Powis G.

Org Biomol Chem. 2004 Jun 7;2(11):1651-8. Epub 2004 May 11.

PMID:
15162219
8.

Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302.

Li S, Zhang J, Li J, Chen D, Matteucci M, Curd J, Duan JX.

Biol Trace Elem Res. 2010 Sep;136(3):294-301. doi: 10.1007/s12011-009-8544-1. Epub 2009 Oct 17.

PMID:
19838642
9.

The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy.

Biaglow JE, Miller RA.

Cancer Biol Ther. 2005 Jan;4(1):6-13. Epub 2004 Jan 8. Review.

PMID:
15684606
10.

Inhibition of thioredoxin and thioredoxin reductase by 4-hydroxy-2-nonenal in vitro and in vivo.

Fang J, Holmgren A.

J Am Chem Soc. 2006 Feb 15;128(6):1879-85.

PMID:
16464088
11.

Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II).

Sasada T, Nakamura H, Ueda S, Sato N, Kitaoka Y, Gon Y, Takabayashi A, Spyrou G, Holmgren A, Yodoi J.

Free Radic Biol Med. 1999 Sep;27(5-6):504-14.

PMID:
10490269
12.

Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system.

Wipf P, Lynch SM, Powis G, Birmingham A, Englund EE.

Org Biomol Chem. 2005 Nov 7;3(21):3880-2. Epub 2005 Sep 28.

PMID:
16240002
13.

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system.

Nordberg J, Arnér ES.

Free Radic Biol Med. 2001 Dec 1;31(11):1287-312. Review.

PMID:
11728801
14.

Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties.

Rubbiani R, Kitanovic I, Alborzinia H, Can S, Kitanovic A, Onambele LA, Stefanopoulou M, Geldmacher Y, Sheldrick WS, Wolber G, Prokop A, Wölfl S, Ott I.

J Med Chem. 2010 Dec 23;53(24):8608-18. doi: 10.1021/jm100801e. Epub 2010 Nov 17.

PMID:
21082862
15.

Parallel syntheses of disulfide inhibitors of the thioredoxin redox system as potential antitumor agents.

Kirkpatrick DL, Watson S, Kunkel M, Fletcher S, Ulhaq S, Powis G.

Anticancer Drug Des. 1999 Oct;14(5):421-32.

PMID:
10766297
16.

Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity.

Lu J, Papp LV, Fang J, Rodriguez-Nieto S, Zhivotovsky B, Holmgren A.

Cancer Res. 2006 Apr 15;66(8):4410-8.

17.

New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead.

Wipf P, Hopkins TD, Jung JK, Rodriguez S, Birmingham A, Southwick EC, Lazo JS, Powis G.

Bioorg Med Chem Lett. 2001 Oct 8;11(19):2637-41.

PMID:
11551767
18.

Recent advances in the development of thioredoxin reductase inhibitors as anticancer agents.

Liu Y, Li Y, Yu S, Zhao G.

Curr Drug Targets. 2012 Oct;13(11):1432-44. Review.

PMID:
22876886
19.

A diterpenoid derivate compound targets selenocysteine of thioredoxin reductases and induces Bax/Bak-independent apoptosis.

Liu J, Mu C, Yue W, Li J, Ma B, Zhao L, Liu L, Chen Q, Yan C, Liu H, Hao X, Zhu Y.

Free Radic Biol Med. 2013 Oct;63:485-94. doi: 10.1016/j.freeradbiomed.2013.05.038. Epub 2013 May 31.

PMID:
23732520
20.

The effects of acrolein on peroxiredoxins, thioredoxins, and thioredoxin reductase in human bronchial epithelial cells.

Myers CR, Myers JM.

Toxicology. 2009 Mar 4;257(1-2):95-104. doi: 10.1016/j.tox.2008.12.013. Epub 2008 Dec 24.

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