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Results: 1 to 20 of 101

1.

Assembly of the presenilin γ-/ε-secretase complex.

St George-Hyslop P, Fraser PE.

J Neurochem. 2012 Jan;120 Suppl 1:84-8. doi: 10.1111/j.1471-4159.2011.07505.x. Epub 2011 Nov 28. Review.

PMID:
22122073
[PubMed - indexed for MEDLINE]
2.

Toward the structure of presenilin/γ-secretase and presenilin homologs.

Wolfe MS.

Biochim Biophys Acta. 2013 Dec;1828(12):2886-97. doi: 10.1016/j.bbamem.2013.04.015. Review.

PMID:
24099007
[PubMed - indexed for MEDLINE]
3.

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.

Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM.

J Biol Chem. 2009 Jan 30;284(5):2967-77. doi: 10.1074/jbc.M807269200. Epub 2008 Nov 25.

PMID:
19036728
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Presenilin: running with scissors in the membrane.

Selkoe DJ, Wolfe MS.

Cell. 2007 Oct 19;131(2):215-21. Review.

PMID:
17956719
[PubMed - indexed for MEDLINE]
Free Article
5.

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

Quintero-Monzon O, Martin MM, Fernandez MA, Cappello CA, Krzysiak AJ, Osenkowski P, Wolfe MS.

Biochemistry. 2011 Oct 25;50(42):9023-35. doi: 10.1021/bi2007146. Epub 2011 Sep 30.

PMID:
21919498
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Comparison of presenilin 1 and presenilin 2 γ-secretase activities using a yeast reconstitution system.

Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S.

J Biol Chem. 2011 Dec 30;286(52):44569-75. doi: 10.1074/jbc.M111.270108. Epub 2011 Nov 10.

PMID:
22074918
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.

Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B.

Science. 2009 May 1;324(5927):639-42. doi: 10.1126/science.1171176. Epub 2009 Mar 19.

PMID:
19299585
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.

Pardossi-Piquard R, Yang SP, Kanemoto S, Gu Y, Chen F, Böhm C, Sevalle J, Li T, Wong PC, Checler F, Schmitt-Ulms G, St George-Hyslop P, Fraser PE.

J Biol Chem. 2009 Jun 12;284(24):16298-307. doi: 10.1074/jbc.M109.000067. Epub 2009 Apr 15.

PMID:
19369254
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.

Lee J, Song L, Terracina G, Bara T, Josien H, Asberom T, Sasikumar TK, Burnett DA, Clader J, Parker EM, Zhang L.

Biochemistry. 2011 Jun 7;50(22):4973-80. doi: 10.1021/bi200026m. Epub 2011 May 13.

PMID:
21528914
[PubMed - indexed for MEDLINE]
10.
11.

The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.

Wanngren J, Frånberg J, Svensson AI, Laudon H, Olsson F, Winblad B, Liu F, Näslund J, Lundkvist J, Karlström H.

J Biol Chem. 2010 Mar 19;285(12):8527-36. doi: 10.1074/jbc.M109.055590. Epub 2010 Jan 27.

PMID:
20106965
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P.

Nature. 2006 Apr 27;440(7088):1208-12.

PMID:
16641999
[PubMed - indexed for MEDLINE]
13.

The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.

Hussain I, Fabrègue J, Anderes L, Ousson S, Borlat F, Eligert V, Berger S, Dimitrov M, Alattia JR, Fraering PC, Beher D.

J Biol Chem. 2013 Jan 25;288(4):2521-31. doi: 10.1074/jbc.M112.370924. Epub 2012 Dec 3.

PMID:
23209290
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin.

Meckler X, Roseman J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, Thinakaran G.

J Neurosci. 2010 Dec 1;30(48):16160-9. doi: 10.1523/JNEUROSCI.4436-10.2010.

PMID:
21123562
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Identification of gamma-secretase inhibitor potency determinants on presenilin.

Zhao B, Yu M, Neitzel M, Marugg J, Jagodzinski J, Lee M, Hu K, Schenk D, Yednock T, Basi G.

J Biol Chem. 2008 Feb 1;283(5):2927-38. Epub 2007 Nov 21.

PMID:
18032377
[PubMed - indexed for MEDLINE]
Free Article
16.

Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization.

Fassler M, Li X, Kaether C.

J Biol Chem. 2011 Nov 4;286(44):38390-6. doi: 10.1074/jbc.M111.252429. Epub 2011 Sep 13.

PMID:
21914807
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Signature amyloid β profiles are produced by different γ-secretase complexes.

Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B.

J Biol Chem. 2014 Feb 14;289(7):4346-55. doi: 10.1074/jbc.M113.530907. Epub 2013 Dec 13.

PMID:
24338474
[PubMed - indexed for MEDLINE]
18.

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C.

J Neurochem. 2004 Jun;89(6):1520-7.

PMID:
15189355
[PubMed - indexed for MEDLINE]
19.

Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network.

Siman R, Velji J.

J Neurochem. 2003 Mar;84(5):1143-53.

PMID:
12603837
[PubMed - indexed for MEDLINE]
20.

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.

Marlow L, Canet RM, Haugabook SJ, Hardy JA, Lahiri DK, Sambamurti K.

Biochem Biophys Res Commun. 2003 Jun 6;305(3):502-9. Erratum in: Biochem Biophys Res Commun. 2003 Aug 1;307(3):756.

PMID:
12763021
[PubMed - indexed for MEDLINE]

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