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Pro-inflammatory phenotype of COPD fibroblasts not compatible with repair in COPD lung.

Zhang J, Wu L, Qu JM, Bai CX, Merrilees MJ, Black PN.

J Cell Mol Med. 2012 Jul;16(7):1522-32. doi: 10.1111/j.1582-4934.2011.01492.x.


Telomere Dysfunction and Cell Senescence in Chronic Lung Diseases: Therapeutic Potential.

Adnot S, Amsellem V, Boyer L, Marcos E, Saker M, Houssaini A, Kebe K, Dagouassat M, Lipskaia L, Boczkowski J.

Pharmacol Ther. 2015 Jun 18. pii: S0163-7258(15)00122-9. doi: 10.1016/j.pharmthera.2015.06.007. [Epub ahead of print] Review.


Matrix Metalloproteinases-1 and -2 Mediate IL-13-induced Suppression of Elastin in Airway Fibroblasts in Asthma.

Ingram JL, Slade D, Church TD, Francisco D, Heck K, Sigmon RW, Ghio M, Murillo A, Firszt R, Lugogo NL, Que L, Sunday ME, Kraft M.

Am J Respir Cell Mol Biol. 2015 Jun 13. [Epub ahead of print]


Accelerated extracellular matrix turnover during exacerbations of COPD.

Sand JM, Knox AJ, Lange P, Sun S, Kristensen JH, Leeming DJ, Karsdal MA, Bolton CE, Johnson SR.

Respir Res. 2015 Jun 11;16(1):69.


Club Cells, Their Secretory Protein, and COPD.

Barnes PJ.

Chest. 2015 Jun;147(6):1447-8. doi: 10.1378/chest.14-3171. No abstract available.


Knockdown of versican 1 blocks cigarette-induced loss of insoluble elastin in human lung fibroblasts.

Xu LL, Lu YT, Zhang J, Wu L, Merrilees MJ, Qu JM.

Respir Physiol Neurobiol. 2015 Aug 15;215:58-63. doi: 10.1016/j.resp.2015.05.004. Epub 2015 May 18.


Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway.

Figeac F, Dagouassat M, Mahrouf-Yorgov M, Le Gouvello S, Trébeau C, Sayed A, Stern JB, Validire P, Dubois-Randé JL, Boczkowski J, Mus-Veteau I, Rodriguez AM.

PLoS One. 2015 Mar 27;10(3):e0121579. doi: 10.1371/journal.pone.0121579. eCollection 2015.


Increased IL-33 expression in chronic obstructive pulmonary disease.

Xia J, Zhao J, Shang J, Li M, Zeng Z, Zhao J, Wang J, Xu Y, Xie J.

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 1;308(7):L619-27. doi: 10.1152/ajplung.00305.2014. Epub 2015 Jan 16.


Effect of culture conditions on microRNA expression in primary adult control and COPD lung fibroblasts in vitro.

Ikari J, Smith LM, Nelson AJ, Iwasawa S, Gunji Y, Farid M, Wang X, Basma H, Feghali-Bostwick C, Liu X, DeMeo DL, Rennard SI.

In Vitro Cell Dev Biol Anim. 2015 Apr;51(4):390-9. doi: 10.1007/s11626-014-9820-8. Epub 2015 Jan 1.


Delay of airway epithelial wound repair in COPD is associated with airflow obstruction severity.

Perotin JM, Adam D, Vella-Boucaud J, Delepine G, Sandu S, Jonvel AC, Prevost A, Berthiot G, Pison C, Lebargy F, Birembaut P, Coraux C, Deslee G.

Respir Res. 2014 Nov 27;15:151. doi: 10.1186/s12931-014-0151-9.


Electroacupuncture at Feishu (BL13) and Zusanli (ST36) down-regulates the expression of orexins and their receptors in rats with chronic obstructive pulmonary disease.

Zhang XF, Zhu J, Geng WY, Zhao SJ, Jiang CW, Cai SR, Cheng M, Zhou CY, Liu ZB.

J Integr Med. 2014 Sep;12(5):417-24. doi: 10.1016/S2095-4964(14)60040-6.


Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease.

Kumar M, Seeger W, Voswinckel R.

Am J Respir Cell Mol Biol. 2014 Sep;51(3):323-33. doi: 10.1165/rcmb.2013-0382PS. Review.


Interleukin-6 and interleukin-8 blood levels' poor association with the severity and clinical profile of ex-smokers with COPD.

de Moraes MR, da Costa AC, Corrêa Kde S, Junqueira-Kipnis AP, Rabahi MF.

Int J Chron Obstruct Pulmon Dis. 2014 Jul 29;9:735-43. doi: 10.2147/COPD.S64135. eCollection 2014.


A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD.

Brandsma CA, van den Berge M, Postma DS, Jonker MR, Brouwer S, Paré PD, Sin DD, Bossé Y, Laviolette M, Karjalainen J, Fehrmann RS, Nickle DC, Hao K, Spanjer AI, Timens W, Franke L.

Thorax. 2015 Jan;70(1):21-32. doi: 10.1136/thoraxjnl-2014-205091. Epub 2014 Jul 2.


Use of versican variant V3 and versican antisense expression to engineer cultured human skin containing increased content of insoluble elastin.

Merrilees MJ, Falk BA, Zuo N, Dickinson ME, May BC, Wight TN.

J Tissue Eng Regen Med. 2014 Jun 19. doi: 10.1002/term.1913. [Epub ahead of print]


Increased serum levels of lipocalin-1 and -2 in patients with stable chronic obstructive pulmonary disease.

Wang XR, Li YP, Gao S, Xia W, Gao K, Kong QH, Qi H, Wu L, Zhang J, Qu JM, Bai CX.

Int J Chron Obstruct Pulmon Dis. 2014 May 27;9:543-9. doi: 10.2147/COPD.S62700. eCollection 2014.


Similar matrix alterations in alveolar and small airway walls of COPD patients.

Eurlings IM, Dentener MA, Cleutjens JP, Peutz CJ, Rohde GG, Wouters EF, Reynaert NL.

BMC Pulm Med. 2014 May 26;14:90. doi: 10.1186/1471-2466-14-90.


Differential expression of C-reactive protein and serum amyloid A in different cell types in the lung tissue of chronic obstructive pulmonary disease patients.

Calero C, Arellano E, Lopez-Villalobos JL, Sánchez-López V, Moreno-Mata N, López-Campos JL.

BMC Pulm Med. 2014 May 30;14:95. doi: 10.1186/1471-2466-14-95.


Overexpression of CD163, CD204 and CD206 on alveolar macrophages in the lungs of patients with severe chronic obstructive pulmonary disease.

Kaku Y, Imaoka H, Morimatsu Y, Komohara Y, Ohnishi K, Oda H, Takenaka S, Matsuoka M, Kawayama T, Takeya M, Hoshino T.

PLoS One. 2014 Jan 30;9(1):e87400. doi: 10.1371/journal.pone.0087400. eCollection 2014.


Comparison of clinical features between non-smokers with COPD and smokers with COPD: a retrospective observational study.

Zhang J, Lin XF, Bai CX.

Int J Chron Obstruct Pulmon Dis. 2014;9:57-63. doi: 10.2147/COPD.S52416. Epub 2014 Jan 8.

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