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PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro.

Fukaya T, Tomari Y.

EMBO J. 2011 Nov 25;30(24):4998-5009. doi: 10.1038/emboj.2011.426.


PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding.

Moretti F, Kaiser C, Zdanowicz-Specht A, Hentze MW.

Nat Struct Mol Biol. 2012 May 27;19(6):603-8. doi: 10.1038/nsmb.2309.


MicroRNAs mediate gene silencing via multiple different pathways in drosophila.

Fukaya T, Tomari Y.

Mol Cell. 2012 Dec 28;48(6):825-36. doi: 10.1016/j.molcel.2012.09.024. Epub 2012 Nov 1.


The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets.

Huntzinger E, Kuzuoglu-Öztürk D, Braun JE, Eulalio A, Wohlbold L, Izaurralde E.

Nucleic Acids Res. 2013 Jan;41(2):978-94. doi: 10.1093/nar/gks1078. Epub 2012 Nov 21.


Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF, Sonenberg N.

Mol Cell. 2009 Sep 24;35(6):868-80. doi: 10.1016/j.molcel.2009.08.004. Epub 2009 Aug 27.


GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation.

Zekri L, Kuzuoğlu-Öztürk D, Izaurralde E.

EMBO J. 2013 Apr 3;32(7):1052-65. doi: 10.1038/emboj.2013.44. Epub 2013 Mar 5.


Argonaute-mediated translational repression (and activation).

Iwasaki S, Tomari Y.

Fly (Austin). 2009 Jul-Sep;3(3):204-6. Epub 2009 Jul 14. Review.


The role of GW182 proteins in miRNA-mediated gene silencing.

Braun JE, Huntzinger E, Izaurralde E.

Adv Exp Med Biol. 2013;768:147-63. doi: 10.1007/978-1-4614-5107-5_9. Review.


The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release.

Zekri L, Huntzinger E, Heimstädt S, Izaurralde E.

Mol Cell Biol. 2009 Dec;29(23):6220-31. doi: 10.1128/MCB.01081-09. Epub 2009 Sep 21.


Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression.

Iwasaki S, Kawamata T, Tomari Y.

Mol Cell. 2009 Apr 10;34(1):58-67. doi: 10.1016/j.molcel.2009.02.010. Epub 2009 Mar 5.


Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression.

Takimoto K, Wakiyama M, Yokoyama S.

RNA. 2009 Jun;15(6):1078-89. doi: 10.1261/rna.1363109. Epub 2009 Apr 27.


Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway.

Miyoshi K, Okada TN, Siomi H, Siomi MC.

RNA. 2009 Jul;15(7):1282-91. doi: 10.1261/rna.1541209. Epub 2009 May 18.


MicroRNAs block assembly of eIF4F translation initiation complex in Drosophila.

Fukaya T, Iwakawa HO, Tomari Y.

Mol Cell. 2014 Oct 2;56(1):67-78. doi: 10.1016/j.molcel.2014.09.004.


A C-terminal silencing domain in GW182 is essential for miRNA function.

Eulalio A, Helms S, Fritzsch C, Fauser M, Izaurralde E.

RNA. 2009 Jun;15(6):1067-77. doi: 10.1261/rna.1605509. Epub 2009 Apr 21.


The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability.

Omer AD, Janas MM, Novina CD.

Mol Cell. 2009 Sep 24;35(6):739-40. doi: 10.1016/j.molcel.2009.09.003.


GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay.

Eulalio A, Huntzinger E, Izaurralde E.

Nat Struct Mol Biol. 2008 Apr;15(4):346-53. doi: 10.1038/nsmb.1405. Epub 2008 Mar 16.


mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes.

Behm-Ansmant I, Rehwinkel J, Doerks T, Stark A, Bork P, Izaurralde E.

Genes Dev. 2006 Jul 15;20(14):1885-98. Epub 2006 Jun 30.


miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs.

Chekulaeva M, Mathys H, Zipprich JT, Attig J, Colic M, Parker R, Filipowicz W.

Nat Struct Mol Biol. 2011 Oct 7;18(11):1218-26. doi: 10.1038/nsmb.2166.


Structural determinants of miRNAs for RISC loading and slicer-independent unwinding.

Kawamata T, Seitz H, Tomari Y.

Nat Struct Mol Biol. 2009 Sep;16(9):953-60. doi: 10.1038/nsmb.1630. Epub 2009 Aug 16.


Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster.

Rehwinkel J, Natalin P, Stark A, Brennecke J, Cohen SM, Izaurralde E.

Mol Cell Biol. 2006 Apr;26(8):2965-75.

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