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Results: 1 to 20 of 118

1.

Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.

Lorbek G, Lewinska M, Rozman D.

FEBS J. 2012 May;279(9):1516-33. doi: 10.1111/j.1742-4658.2011.08432.x. Epub 2011 Dec 22. Review.

PMID:
22111624
[PubMed - indexed for MEDLINE]
2.

Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats.

Chen W, Suruga K, Nishimura N, Gouda T, Lam VN, Yokogoshi H.

Life Sci. 2005 Jul 1;77(7):746-57. Epub 2005 Mar 19.

PMID:
15936349
[PubMed - indexed for MEDLINE]
3.

Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.

Schwarz M, Russell DW, Dietschy JM, Turley SD.

J Lipid Res. 2001 Oct;42(10):1594-603.

PMID:
11590215
[PubMed - indexed for MEDLINE]
Free Article
4.

Regulation of bile acid synthesis.

Chiang JY.

Front Biosci. 1998 Feb 15;3:d176-93. Review.

PMID:
9450986
[PubMed - indexed for MEDLINE]
5.

Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity.

Tiemann M, Han Z, Soccio R, Bollineni J, Shefer S, Sehayek E, Breslow JL.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1846-51. Epub 2004 Feb 4.

PMID:
14762172
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice.

Wang J, Einarsson C, Murphy C, Parini P, Björkhem I, Gåfvels M, Eggertsen G.

J Lipid Res. 2006 Feb;47(2):421-30. Epub 2005 Nov 1.

PMID:
16264196
[PubMed - indexed for MEDLINE]
Free Article
7.

Expression of sterol 12alpha-hydroxylase alters bile acid pool composition in primary rat hepatocytes and in vivo.

Pandak WM, Bohdan P, Franklund C, Mallonee DH, Eggertsen G, Björkhem I, Gil G, Vlahcevic ZR, Hylemon PB.

Gastroenterology. 2001 Jun;120(7):1801-9.

PMID:
11375960
[PubMed - indexed for MEDLINE]
8.

Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.

Repa JJ, Lund EG, Horton JD, Leitersdorf E, Russell DW, Dietschy JM, Turley SD.

J Biol Chem. 2000 Dec 15;275(50):39685-92.

PMID:
11001949
[PubMed - indexed for MEDLINE]
Free Article
9.

Feedback regulation of bile acid synthesis in primary human hepatocytes: evidence that CDCA is the strongest inhibitor.

Ellis E, Axelson M, Abrahamsson A, Eggertsen G, Thörne A, Nowak G, Ericzon BG, Björkhem I, Einarsson C.

Hepatology. 2003 Oct;38(4):930-8.

PMID:
14512880
[PubMed - indexed for MEDLINE]
10.

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.

Goodwin B, Gauthier KC, Umetani M, Watson MA, Lochansky MI, Collins JL, Leitersdorf E, Mangelsdorf DJ, Kliewer SA, Repa JJ.

Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8. Epub 2002 Dec 30.

PMID:
12509506
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.

Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, Bollineni JS, Shefer S, Hyogo H, Cohen DE, Shneider B, Sehayek E, Ananthanarayanan M, Balasubramaniyan N, Suchy FJ, Batta AK, Salen G.

J Lipid Res. 2003 May;44(5):1001-9. Epub 2003 Feb 16.

PMID:
12588950
[PubMed - indexed for MEDLINE]
Free Article
12.

Differential effects of 17alpha-ethinylestradiol on the neutral and acidic pathways of bile salt synthesis in the rat.

Koopen NR, Post SM, Wolters H, Havinga R, Stellaard F, Boverhof R, Kuipers F, Princen HM.

J Lipid Res. 1999 Jan;40(1):100-8.

PMID:
9869655
[PubMed - indexed for MEDLINE]
Free Article
13.

Differences in the regulation of the classical and the alternative pathway for bile acid synthesis in human liver. No coordinate regulation of CYP7A1 and CYP27A1.

Björkhem I, Araya Z, Rudling M, Angelin B, Einarsson C, Wikvall K.

J Biol Chem. 2002 Jul 26;277(30):26804-7. Epub 2002 May 13.

PMID:
12011083
[PubMed - indexed for MEDLINE]
Free Article
14.

Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene.

Rosen H, Reshef A, Maeda N, Lippoldt A, Shpizen S, Triger L, Eggertsen G, Björkhem I, Leitersdorf E.

J Biol Chem. 1998 Jun 12;273(24):14805-12.

PMID:
9614081
[PubMed - indexed for MEDLINE]
Free Article
15.

Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes.

Ellis EC.

World J Gastroenterol. 2006 Aug 7;12(29):4640-5.

PMID:
16937432
[PubMed - indexed for MEDLINE]
Free Article
16.

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.

Schwarz M, Lund EG, Setchell KD, Kayden HJ, Zerwekh JE, Björkhem I, Herz J, Russell DW.

J Biol Chem. 1996 Jul 26;271(30):18024-31.

PMID:
8663430
[PubMed - indexed for MEDLINE]
Free Article
17.

Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.

Heverin M, Meaney S, Brafman A, Shafir M, Olin M, Shafaati M, von Bahr S, Larsson L, Lövgren-Sandblom A, Diczfalusy U, Parini P, Feinstein E, Björkhem I.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2191-7. Epub 2007 Aug 30.

PMID:
17761942
[PubMed - indexed for MEDLINE]
Free Article
18.

Regulation of classic and alternative bile acid synthesis in hypercholesterolemic rabbits: effects of cholesterol feeding and bile acid depletion.

Xu G, Salen G, Shefer S, Tint GS, Nguyen LB, Parker TT, Chen TS, Roberts J, Kong X, Greenblatt D.

J Lipid Res. 1998 Aug;39(8):1608-15.

PMID:
9717721
[PubMed - indexed for MEDLINE]
Free Article
19.

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice.

Li-Hawkins J, Gåfvels M, Olin M, Lund EG, Andersson U, Schuster G, Björkhem I, Russell DW, Eggertsen G.

J Clin Invest. 2002 Oct;110(8):1191-200.

PMID:
12393855
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase.

Shefer S, Kren BT, Salen G, Steer CJ, Nguyen LB, Chen T, Tint GS, Batta AK.

Hepatology. 1995 Oct;22(4 Pt 1):1215-21.

PMID:
7557873
[PubMed - indexed for MEDLINE]

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