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Results: 1 to 20 of 105

1.

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity.

Yang SB, Lee HY, Young DM, Tien AC, Rowson-Baldwin A, Shu YY, Jan YN, Jan LY.

J Mol Med (Berl). 2012 May;90(5):575-85. doi: 10.1007/s00109-011-0834-3. Epub 2011 Nov 22.

PMID:
22105852
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Novel culture technique involving an histone deacetylase inhibitor reduces the marginal islet mass to correct streptozotocin-induced diabetes.

Shin JS, Min BH, Lim JY, Kim BK, Han HJ, Yoon KH, Kim SJ, Park CG.

Cell Transplant. 2011;20(9):1321-32. doi: 10.3727/096368910X557146. Epub 2011 Feb 3.

PMID:
21294957
[PubMed - indexed for MEDLINE]
3.

Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity.

Bonomi L, Brown M, Ungerleider N, Muse M, Matzuk MM, Schneyer A.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E587-96. doi: 10.1152/ajpendo.00177.2012. Epub 2012 Jun 26.

PMID:
22739106
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Rapamycin impairs metabolism-secretion coupling in rat pancreatic islets by suppressing carbohydrate metabolism.

Shimodahira M, Fujimoto S, Mukai E, Nakamura Y, Nishi Y, Sasaki M, Sato Y, Sato H, Hosokawa M, Nagashima K, Seino Y, Inagaki N.

J Endocrinol. 2010 Jan;204(1):37-46. doi: 10.1677/JOE-09-0216. Epub 2009 Oct 7.

PMID:
19812126
[PubMed - indexed for MEDLINE]
Free Article
5.

A novel dipeptidyl peptidase IV inhibitor DA-1229 ameliorates streptozotocin-induced diabetes by increasing β-cell replication and neogenesis.

Cho JM, Jang HW, Cheon H, Jeong YT, Kim DH, Lim YM, Choi SH, Yang EK, Shin CY, Son MH, Kim SH, Kim HJ, Lee MS.

Diabetes Res Clin Pract. 2011 Jan;91(1):72-9. doi: 10.1016/j.diabres.2010.10.012. Epub 2010 Nov 18.

PMID:
21093089
[PubMed - indexed for MEDLINE]
6.

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE.

Aging Cell. 2013 Aug;12(4):712-8. doi: 10.1111/acel.12097. Epub 2013 Jun 7.

PMID:
23648089
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter.

Annerén C, Welsh M, Jansson L.

Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1183-90. Epub 2006 Dec 19.

PMID:
17179392
[PubMed - indexed for MEDLINE]
Free Article
8.

Activation of protein kinase C-ζ in pancreatic β-cells in vivo improves glucose tolerance and induces β-cell expansion via mTOR activation.

Velazquez-Garcia S, Valle S, Rosa TC, Takane KK, Demirci C, Alvarez-Perez JC, Mellado-Gil JM, Ernst S, Scott DK, Vasavada RC, Alonso LC, Garcia-Ocaña A.

Diabetes. 2011 Oct;60(10):2546-59. doi: 10.2337/db10-1783. Epub 2011 Sep 12.

PMID:
21911744
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion.

Robson-Doucette CA, Sultan S, Allister EM, Wikstrom JD, Koshkin V, Bhattacharjee A, Prentice KJ, Sereda SB, Shirihai OS, Wheeler MB.

Diabetes. 2011 Nov;60(11):2710-9. doi: 10.2337/db11-0132. Epub 2011 Oct 7.

PMID:
21984579
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Insulinotropic effect of the non-steroidal compound STX in pancreatic β-cells.

Ropero AB, Alonso-Magdalena P, Soriano S, Juan-Picó P, Roepke TA, Kelly MJ, Nadal Á.

PLoS One. 2012;7(4):e34650. doi: 10.1371/journal.pone.0034650. Epub 2012 Apr 10. Erratum in: PLoS One. 2012;7(5): doi/10.1371/annotation/c1da4989-c6e8-43c2-9a8b-1462af83ae5e.

PMID:
22506040
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.

Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR.

Nat Genet. 2002 May;31(1):111-5. Epub 2002 Apr 1.

PMID:
11923875
[PubMed - indexed for MEDLINE]
12.

Telomerase deficiency impairs glucose metabolism and insulin secretion.

Kuhlow D, Florian S, von Figura G, Weimer S, Schulz N, Petzke KJ, Zarse K, Pfeiffer AF, Rudolph KL, Ristow M.

Aging (Albany NY). 2010 Oct;2(10):650-8.

PMID:
20876939
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse.

Bahrami J, Longuet C, Baggio LL, Li K, Drucker DJ.

Gastroenterology. 2010 Sep;139(3):857-68. doi: 10.1053/j.gastro.2010.05.006. Epub 2010 Jun 11.

PMID:
20546737
[PubMed - indexed for MEDLINE]
14.

Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets.

Johnson JD, Ao Z, Ao P, Li H, Dai LJ, He Z, Tee M, Potter KJ, Klimek AM, Meloche RM, Thompson DM, Verchere CB, Warnock GL.

Cell Transplant. 2009;18(8):833-45. doi: 10.3727/096368909X471198. Epub 2009 Apr 10.

PMID:
19500470
[PubMed - indexed for MEDLINE]
15.
16.

Evidence for rapamycin toxicity in pancreatic β-cells and a review of the underlying molecular mechanisms.

Barlow AD, Nicholson ML, Herbert TP.

Diabetes. 2013 Aug;62(8):2674-82. doi: 10.2337/db13-0106. Review.

PMID:
23881200
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.

Fex M, Nitert MD, Wierup N, Sundler F, Ling C, Mulder H.

Diabetologia. 2007 Jan;50(1):74-83. Epub 2006 Nov 9.

PMID:
17093947
[PubMed - indexed for MEDLINE]
18.

Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion.

Lazo de la Vega-Monroy ML, Larrieta E, German MS, Baez-Saldana A, Fernandez-Mejia C.

J Nutr Biochem. 2013 Jan;24(1):169-77. doi: 10.1016/j.jnutbio.2012.03.020. Epub 2012 Jul 25.

PMID:
22841397
[PubMed - indexed for MEDLINE]
19.

Rapamycin induces autophagy in islets: relevance in islet transplantation.

Tanemura M, Saga A, Kawamoto K, Machida T, Deguchi T, Nishida T, Sawa Y, Doki Y, Mori M, Ito T.

Transplant Proc. 2009 Jan-Feb;41(1):334-8. doi: 10.1016/j.transproceed.2008.10.032.

PMID:
19249550
[PubMed - indexed for MEDLINE]
20.

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats.

Deblon N, Bourgoin L, Veyrat-Durebex C, Peyrou M, Vinciguerra M, Caillon A, Maeder C, Fournier M, Montet X, Rohner-Jeanrenaud F, Foti M.

Br J Pharmacol. 2012 Apr;165(7):2325-40. doi: 10.1111/j.1476-5381.2011.01716.x.

PMID:
22014210
[PubMed - indexed for MEDLINE]
Free PMC Article

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