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Items: 1 to 20 of 102

1.

P-21 activated kinase 1 knockdown inhibits β-catenin signalling and blocks colorectal cancer growth.

He H, Huynh N, Liu KH, Malcontenti-Wilson C, Zhu J, Christophi C, Shulkes A, Baldwin GS.

Cancer Lett. 2012 Apr 1;317(1):65-71. doi: 10.1016/j.canlet.2011.11.014. Epub 2011 Nov 15.

PMID:
22100495
2.

ITF2 prevents activation of the β-catenin-TCF4 complex in colon cancer cells and levels decrease with tumor progression.

Shin HW, Choi H, So D, Kim YI, Cho K, Chung HJ, Lee KH, Chun YS, Cho CH, Kang GH, Kim WH, Park JW.

Gastroenterology. 2014 Aug;147(2):430-442.e8. doi: 10.1053/j.gastro.2014.04.047. Epub 2014 May 15.

PMID:
24846398
3.

P21-activated kinase 1 promotes colorectal cancer survival by up-regulation of hypoxia-inducible factor-1α.

Liu KH, Huynh N, Patel O, Shulkes A, Baldwin G, He H.

Cancer Lett. 2013 Oct 28;340(1):22-9. doi: 10.1016/j.canlet.2013.06.024. Epub 2013 Jun 26.

PMID:
23811286
4.

Preclinical evaluation of destruxin B as a novel Wnt signaling target suppressing proliferation and metastasis of colorectal cancer using non-invasive bioluminescence imaging.

Yeh CT, Rao YK, Ye M, Wu WS, Chang TC, Wang LS, Wu CH, Wu AT, Tzeng YM.

Toxicol Appl Pharmacol. 2012 May 15;261(1):31-41. doi: 10.1016/j.taap.2012.03.007. Epub 2012 Mar 23.

PMID:
22465936
5.

GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.

Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C, Wei Y.

Carcinogenesis. 2013 Dec;34(12):2861-9. doi: 10.1093/carcin/bgt229. Epub 2013 Jun 26.

6.

Colorectal tumors are effectively eradicated by combined inhibition of {beta}-catenin, KRAS, and the oncogenic transcription factor ITF2.

Mologni L, Dekhil H, Ceccon M, Purgante S, Lan C, Cleris L, Magistroni V, Formelli F, Gambacorti-Passerini CB.

Cancer Res. 2010 Sep 15;70(18):7253-63. doi: 10.1158/0008-5472.CAN-10-1108. Epub 2010 Sep 7.

7.

A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.

Shah M, Rennoll SA, Raup-Konsavage WM, Yochum GS.

Cell Cycle. 2015;14(3):323-32. doi: 10.4161/15384101.2014.980643.

8.

PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins.

He H, Shulkes A, Baldwin GS.

Biochim Biophys Acta. 2008 Oct;1783(10):1943-54. doi: 10.1016/j.bbamcr.2008.04.016. Epub 2008 May 3.

9.

PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation.

Qing H, Gong W, Che Y, Wang X, Peng L, Liang Y, Wang W, Deng Q, Zhang H, Jiang B.

Tumour Biol. 2012 Aug;33(4):985-94. doi: 10.1007/s13277-012-0327-1. Epub 2012 Jan 18.

PMID:
22252525
10.

Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells.

Konsavage WM Jr, Kyler SL, Rennoll SA, Jin G, Yochum GS.

J Biol Chem. 2012 Apr 6;287(15):11730-9. doi: 10.1074/jbc.M111.327767. Epub 2012 Feb 15.

11.

Knockdown of PAK4 or PAK1 inhibits the proliferation of mutant KRAS colon cancer cells independently of RAF/MEK/ERK and PI3K/AKT signaling.

Tabusa H, Brooks T, Massey AJ.

Mol Cancer Res. 2013 Feb;11(2):109-21. doi: 10.1158/1541-7786.MCR-12-0466. Epub 2012 Dec 10.

12.

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways.

Huynh N, Liu KH, Baldwin GS, He H.

Biochim Biophys Acta. 2010 Sep;1803(9):1106-13. doi: 10.1016/j.bbamcr.2010.05.007. Epub 2010 Jun 1.

13.

β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.

Satow R, Shitashige M, Jigami T, Fukami K, Honda K, Kitabayashi I, Yamada T.

Gastroenterology. 2012 Mar;142(3):572-81. doi: 10.1053/j.gastro.2011.11.041. Epub 2011 Dec 9.

PMID:
22155184
14.

A novel ent-kaurane diterpenoid executes antitumor function in colorectal cancer cells by inhibiting Wnt/β-catenin signaling.

Ye Q, Yao G, Zhang M, Guo G, Hu Y, Jiang J, Cheng L, Shi J, Li H, Zhang Y, Liu H.

Carcinogenesis. 2015 Mar;36(3):318-26. doi: 10.1093/carcin/bgv003. Epub 2015 Jan 18.

15.

The Bcl-w promoter is activated by beta-catenin/TCF4 in human colorectal carcinoma cells.

Lapham A, Adams JE, Paterson A, Lee M, Brimmell M, Packham G.

Gene. 2009 Mar 1;432(1-2):112-7. doi: 10.1016/j.gene.2008.12.002. Epub 2008 Dec 16.

PMID:
19124064
16.

A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells.

Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W.

Oncogene. 2012 Feb 23;31(8):1001-12. doi: 10.1038/onc.2011.294. Epub 2011 Aug 8.

PMID:
21822311
17.

Phosphorylation of β-catenin at serine 663 regulates its transcriptional activity.

Park MH, Kim DJ, You ST, Lee CS, Kim HK, Park SM, Shin EY, Kim EG.

Biochem Biophys Res Commun. 2012 Mar 16;419(3):543-9. doi: 10.1016/j.bbrc.2012.02.056. Epub 2012 Feb 17.

PMID:
22369945
18.

P-21-activated protein kinase-1 functions as a linker between insulin and Wnt signaling pathways in the intestine.

Sun J, Khalid S, Rozakis-Adcock M, Fantus IG, Jin T.

Oncogene. 2009 Sep 3;28(35):3132-44. doi: 10.1038/onc.2009.167. Epub 2009 Jul 6.

PMID:
19581924
19.

Protein kinase CK2α is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes.

Zou J, Luo H, Zeng Q, Dong Z, Wu D, Liu L.

J Transl Med. 2011 Jun 25;9:97. doi: 10.1186/1479-5876-9-97.

20.

P21-activated protein kinase 1 induces colorectal cancer metastasis involving ERK activation and phosphorylation of FAK at Ser-910.

Li LH, Zheng MH, Luo Q, Ye Q, Feng B, Lu AG, Wang ML, Chen XH, Su LP, Liu BY.

Int J Oncol. 2010 Oct;37(4):951-62.

PMID:
20811717
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