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Results: 1 to 20 of 108

1.

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression.

Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P.

Cell Death Differ. 2012 May;19(5):847-58. doi: 10.1038/cdd.2011.165. Epub 2011 Nov 18.

PMID:
22095285
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.

Lewerenz J, Maher P.

J Biol Chem. 2009 Jan 9;284(2):1106-15. doi: 10.1074/jbc.M807325200. Epub 2008 Nov 18.

PMID:
19017641
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Gamma-tocopheryl quinone, not alpha-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4.

Ogawa Y, Saito Y, Nishio K, Yoshida Y, Ashida H, Niki E.

Free Radic Res. 2008 Jul;42(7):674-87. doi: 10.1080/10715760802277396.

PMID:
18654882
[PubMed - indexed for MEDLINE]
4.

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A.

J Neurochem. 2009 Oct;111(2):332-43. doi: 10.1111/j.1471-4159.2009.06347.x. Epub 2009 Aug 18.

PMID:
19694903
[PubMed - indexed for MEDLINE]
5.

Regulation of xCT expression and system x (c) (-) function in neuronal cells.

Lewerenz J, Maher P, Methner A.

Amino Acids. 2012 Jan;42(1):171-9. doi: 10.1007/s00726-011-0862-x. Epub 2011 Mar 3. Review.

PMID:
21369940
[PubMed - indexed for MEDLINE]
6.

Cooperative action of glutamate transporters and cystine/glutamate antiporter system Xc- protects from oxidative glutamate toxicity.

Lewerenz J, Klein M, Methner A.

J Neurochem. 2006 Aug;98(3):916-25. Epub 2006 Jun 12.

PMID:
16771835
[PubMed - indexed for MEDLINE]
7.

Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative-stress-inducing agent paraquat.

Kobayashi S, Kuwata K, Sugimoto T, Igarashi K, Osaki M, Okada F, Fujii J, Bannai S, Sato H.

Free Radic Biol Med. 2012 Dec 15;53(12):2197-203. doi: 10.1016/j.freeradbiomed.2012.09.040. Epub 2012 Oct 17.

PMID:
23085521
[PubMed - indexed for MEDLINE]
8.

Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

Shih AY, Erb H, Sun X, Toda S, Kalivas PW, Murphy TH.

J Neurosci. 2006 Oct 11;26(41):10514-23.

PMID:
17035536
[PubMed - indexed for MEDLINE]
Free Article
9.

Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation.

Sato H, Nomura S, Maebara K, Sato K, Tamba M, Bannai S.

Biochem Biophys Res Commun. 2004 Dec 3;325(1):109-16.

PMID:
15522208
[PubMed - indexed for MEDLINE]
10.

Activation of stimulatory heterotrimeric G proteins increases glutathione and protects neuronal cells against oxidative stress.

Lewerenz J, Letz J, Methner A.

J Neurochem. 2003 Oct;87(2):522-31.

PMID:
14511129
[PubMed - indexed for MEDLINE]
11.

Nrf2- and ATF4-dependent upregulation of xCT modulates the sensitivity of T24 bladder carcinoma cells to proteasome inhibition.

Ye P, Mimura J, Okada T, Sato H, Liu T, Maruyama A, Ohyama C, Itoh K.

Mol Cell Biol. 2014 Sep 15;34(18):3421-34. doi: 10.1128/MCB.00221-14. Epub 2014 Jul 7.

PMID:
25002527
[PubMed - indexed for MEDLINE]
12.

ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo.

Lange PS, Chavez JC, Pinto JT, Coppola G, Sun CW, Townes TM, Geschwind DH, Ratan RR.

J Exp Med. 2008 May 12;205(5):1227-42. doi: 10.1084/jem.20071460. Epub 2008 May 5.

PMID:
18458112
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.

De Bundel D, Schallier A, Loyens E, Fernando R, Miyashita H, Van Liefferinge J, Vermoesen K, Bannai S, Sato H, Michotte Y, Smolders I, Massie A.

J Neurosci. 2011 Apr 13;31(15):5792-803. doi: 10.1523/JNEUROSCI.5465-10.2011.

PMID:
21490221
[PubMed - indexed for MEDLINE]
Free Article
14.

Increased expression of cystine/glutamate antiporter in multiple sclerosis.

Pampliega O, Domercq M, Soria FN, Villoslada P, Rodríguez-Antigüedad A, Matute C.

J Neuroinflammation. 2011 Jun 3;8:63. doi: 10.1186/1742-2094-8-63.

PMID:
21639880
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.

Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A.

CNS Neurol Disord Drug Targets. 2010 Jul;9(3):373-82. Review.

PMID:
20053169
[PubMed - indexed for MEDLINE]
16.

Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells.

Kim JY, Kanai Y, Chairoungdua A, Cha SH, Matsuo H, Kim DK, Inatomi J, Sawa H, Ida Y, Endou H.

Biochim Biophys Acta. 2001 Jun 6;1512(2):335-44.

PMID:
11406111
[PubMed - indexed for MEDLINE]
17.

Expression of the cystine-glutamate exchanger (xc-) in retinal ganglion cells and regulation by nitric oxide and oxidative stress.

Dun Y, Mysona B, Van Ells T, Amarnath L, Ola MS, Ganapathy V, Smith SB.

Cell Tissue Res. 2006 May;324(2):189-202. Epub 2006 Jan 28.

PMID:
16609915
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Dopaminergic neurons of system x(c)⁻-deficient mice are highly protected against 6-hydroxydopamine-induced toxicity.

Massie A, Schallier A, Kim SW, Fernando R, Kobayashi S, Beck H, De Bundel D, Vermoesen K, Bannai S, Smolders I, Conrad M, Plesnila N, Sato H, Michotte Y.

FASEB J. 2011 Apr;25(4):1359-69. doi: 10.1096/fj.10-177212. Epub 2010 Dec 29.

PMID:
21191088
[PubMed - indexed for MEDLINE]
Free Article
19.

Cystine and glutamate transport in renal epithelial cells transfected with human system x(-) (c).

Bridges CC, Zalups RK.

Kidney Int. 2005 Aug;68(2):653-64.

PMID:
16014042
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells.

Miyamoto N, Izumi H, Miyamoto R, Bin H, Kondo H, Tawara A, Sasaguri Y, Kohno K.

Invest Ophthalmol Vis Sci. 2011 Mar 2;52(3):1226-34. doi: 10.1167/iovs.10-5775.

PMID:
21087962
[PubMed - indexed for MEDLINE]
Free Article

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