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Results: 1 to 20 of 520

1.

Acute activation of central GLP-1 receptors enhances hepatic insulin action and insulin secretion in high-fat-fed, insulin resistant mice.

Burmeister MA, Ferre T, Ayala JE, King EM, Holt RM, Ayala JE.

Am J Physiol Endocrinol Metab. 2012 Feb 1;302(3):E334-43. doi: 10.1152/ajpendo.00409.2011. Epub 2011 Nov 15.

PMID:
22094469
[PubMed - indexed for MEDLINE]
Free Article
2.

GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet.

Parlevliet ET, de Leeuw van Weenen JE, Romijn JA, Pijl H.

Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E318-24. doi: 10.1152/ajpendo.00191.2010. Epub 2010 Jun 8.

PMID:
20530733
[PubMed - indexed for MEDLINE]
Free Article
3.

Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose.

Burmeister MA, Ayala J, Drucker DJ, Ayala JE.

Am J Physiol Endocrinol Metab. 2013 Apr 1;304(7):E677-85. doi: 10.1152/ajpendo.00446.2012. Epub 2013 Jan 22.

PMID:
23341495
[PubMed - indexed for MEDLINE]
Free Article
4.

Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis.

Svegliati-Baroni G, Saccomanno S, Rychlicki C, Agostinelli L, De Minicis S, Candelaresi C, Faraci G, Pacetti D, Vivarelli M, Nicolini D, Garelli P, Casini A, Manco M, Mingrone G, Risaliti A, Frega GN, Benedetti A, Gastaldelli A.

Liver Int. 2011 Oct;31(9):1285-97. doi: 10.1111/j.1478-3231.2011.02462.x. Epub 2011 Feb 15.

PMID:
21745271
[PubMed - indexed for MEDLINE]
5.

An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis.

Baggio LL, Huang Q, Cao X, Drucker DJ.

Gastroenterology. 2008 Apr;134(4):1137-47. doi: 10.1053/j.gastro.2008.01.017. Epub 2008 Jan 11.

PMID:
18313669
[PubMed - indexed for MEDLINE]
6.

Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance.

Ayala JE, Bracy DP, James FD, Burmeister MA, Wasserman DH, Drucker DJ.

Endocrinology. 2010 Oct;151(10):4678-87. doi: 10.1210/en.2010-0289. Epub 2010 Aug 4.

PMID:
20685876
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Pancreatic GLP-1 receptor activation is sufficient for incretin control of glucose metabolism in mice.

Lamont BJ, Li Y, Kwan E, Brown TJ, Gaisano H, Drucker DJ.

J Clin Invest. 2012 Jan 3;122(1):388-402. doi: 10.1172/JCI42497. Epub 2011 Dec 19.

PMID:
22182839
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage.

Knauf C, Cani PD, Perrin C, Iglesias MA, Maury JF, Bernard E, Benhamed F, Grémeaux T, Drucker DJ, Kahn CR, Girard J, Tanti JF, Delzenne NM, Postic C, Burcelin R.

J Clin Invest. 2005 Dec;115(12):3554-63.

PMID:
16322793
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Long-term metabolic benefits of exenatide in mice are mediated solely via the known glucagon-like peptide 1 receptor.

Tatarkiewicz K, Sablan EJ, Polizzi CJ, Villescaz C, Parkes DG.

Am J Physiol Regul Integr Comp Physiol. 2014 Apr 1;306(7):R490-8. doi: 10.1152/ajpregu.00495.2013. Epub 2014 Jan 29.

PMID:
24477544
[PubMed - indexed for MEDLINE]
10.

Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ.

Cabou C, Vachoux C, Campistron G, Drucker DJ, Burcelin R.

Diabetes. 2011 Sep;60(9):2245-56. doi: 10.2337/db11-0464. Epub 2011 Aug 1.

PMID:
21810595
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action.

Ayala JE, Bracy DP, James FD, Julien BM, Wasserman DH, Drucker DJ.

Endocrinology. 2009 Mar;150(3):1155-64. doi: 10.1210/en.2008-0945. Epub 2008 Nov 13.

PMID:
19008308
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.

Panjwani N, Mulvihill EE, Longuet C, Yusta B, Campbell JE, Brown TJ, Streutker C, Holland D, Cao X, Baggio LL, Drucker DJ.

Endocrinology. 2013 Jan;154(1):127-39. doi: 10.1210/en.2012-1937. Epub 2012 Nov 26.

PMID:
23183176
[PubMed - indexed for MEDLINE]
13.

Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase.

Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z, Barzilai N, Oren R, Fishman S.

J Hepatol. 2011 Jun;54(6):1214-23. doi: 10.1016/j.jhep.2010.09.032. Epub 2010 Oct 26.

PMID:
21145820
[PubMed - indexed for MEDLINE]
14.

Insulin action in the double incretin receptor knockout mouse.

Ayala JE, Bracy DP, Hansotia T, Flock G, Seino Y, Wasserman DH, Drucker DJ.

Diabetes. 2008 Feb;57(2):288-97. Epub 2007 Oct 31.

PMID:
17977951
[PubMed - indexed for MEDLINE]
Free Article
15.

Effects of long-term dipeptidyl peptidase-IV inhibition on body composition and glucose tolerance in high fat diet-fed mice.

Liu X, Harada N, Yamane S, Kitajima L, Uchida S, Hamasaki A, Mukai E, Toyoda K, Yamada C, Yamada Y, Seino Y, Inagaki N.

Life Sci. 2009 Jun 19;84(25-26):876-81. doi: 10.1016/j.lfs.2009.03.022. Epub 2009 Apr 7.

PMID:
19358859
[PubMed - indexed for MEDLINE]
16.

Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity.

Cabou C, Campistron G, Marsollier N, Leloup C, Cruciani-Guglielmacci C, Pénicaud L, Drucker DJ, Magnan C, Burcelin R.

Diabetes. 2008 Oct;57(10):2577-87. doi: 10.2337/db08-0121. Epub 2008 Jul 15.

PMID:
18633100
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.

Scrocchi LA, Hill ME, Saleh J, Perkins B, Drucker DJ.

Diabetes. 2000 Sep;49(9):1552-60.

PMID:
10969840
[PubMed - indexed for MEDLINE]
18.

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.

Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D.

Diabetes. 2012 Nov;61(11):2753-62. doi: 10.2337/db11-1556. Epub 2012 Aug 28.

PMID:
22933116
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice.

Gault VA, Bhat VK, Irwin N, Flatt PR.

J Biol Chem. 2013 Dec 6;288(49):35581-91. doi: 10.1074/jbc.M113.512046. Epub 2013 Oct 28.

PMID:
24165127
[PubMed - indexed for MEDLINE]
20.

The common hepatic branch of the vagus is not required to mediate the glycemic and food intake suppressive effects of glucagon-like-peptide-1.

Hayes MR, Kanoski SE, De Jonghe BC, Leichner TM, Alhadeff AL, Fortin SM, Arnold M, Langhans W, Grill HJ.

Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1479-85. doi: 10.1152/ajpregu.00356.2011. Epub 2011 Aug 17.

PMID:
21849636
[PubMed - indexed for MEDLINE]
Free PMC Article

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