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Results: 1 to 20 of 396

1.

Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation.

Panza F, Frisardi V, Solfrizzi V, Imbimbo BP, Logroscino G, Santamato A, Greco A, Seripa D, Pilotto A.

Curr Med Chem. 2011;18(35):5430-47. Review.

PMID:
22087836
[PubMed - indexed for MEDLINE]
2.

γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes.

Imbimbo BP, Giardina GA.

Curr Top Med Chem. 2011;11(12):1555-70. Review.

PMID:
21510832
[PubMed - indexed for MEDLINE]
3.

Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease.

D'Onofrio G, Panza F, Frisardi V, Solfrizzi V, Imbimbo BP, Paroni G, Cascavilla L, Seripa D, Pilotto A.

Expert Opin Drug Discov. 2012 Jan;7(1):19-37. doi: 10.1517/17460441.2012.645534. Epub 2011 Dec 14. Review.

PMID:
22468891
[PubMed - indexed for MEDLINE]
4.

Therapeutic potential of gamma-secretase inhibitors and modulators.

Imbimbo BP.

Curr Top Med Chem. 2008;8(1):54-61. Review.

PMID:
18220933
[PubMed - indexed for MEDLINE]
5.

Therapeutic intervention for Alzheimer's disease with γ-secretase inhibitors: still a viable option?

Imbimbo BP, Panza F, Frisardi V, Solfrizzi V, D'Onofrio G, Logroscino G, Seripa D, Pilotto A.

Expert Opin Investig Drugs. 2011 Mar;20(3):325-41. doi: 10.1517/13543784.2011.550572. Epub 2011 Jan 11. Review.

PMID:
21222550
[PubMed - indexed for MEDLINE]
6.

Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators.

Panza F, Solfrizzi V, Frisardi V, Capurso C, D'Introno A, Colacicco AM, Vendemiale G, Capurso A, Imbimbo BP.

Drugs Aging. 2009;26(7):537-55. doi: 10.2165/11315770-000000000-00000. Review.

PMID:
19655822
[PubMed - indexed for MEDLINE]
7.

γ-Secretase modulator in Alzheimer's disease: shifting the end.

Xia W, Wong ST, Hanlon E, Morin P.

J Alzheimers Dis. 2012;31(4):685-96. doi: 10.3233/JAD-2012-120751. Review.

PMID:
22710916
[PubMed - indexed for MEDLINE]
8.

REVIEW: γ-Secretase inhibitors for the treatment of Alzheimer's disease: The current state.

Panza F, Frisardi V, Imbimbo BP, Capurso C, Logroscino G, Sancarlo D, Seripa D, Vendemiale G, Pilotto A, Solfrizzi V.

CNS Neurosci Ther. 2010 Oct;16(5):272-84. doi: 10.1111/j.1755-5949.2010.00164.x. Epub 2010 Jun 16. Review.

PMID:
20560993
[PubMed - indexed for MEDLINE]
9.

Inhibition of gamma-secretase as a therapeutic intervention for Alzheimer's disease: prospects, limitations and strategies.

Evin G, Sernee MF, Masters CL.

CNS Drugs. 2006;20(5):351-72. Review.

PMID:
16696577
[PubMed - indexed for MEDLINE]
10.

gamma-Secretase as a therapeutic target in Alzheimer's disease.

Guardia-Laguarta C, Pera M, Lleó A.

Curr Drug Targets. 2010 Apr;11(4):506-17. Review.

PMID:
20015011
[PubMed - indexed for MEDLINE]
11.

Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity.

Barten DM, Meredith JE Jr, Zaczek R, Houston JG, Albright CF.

Drugs R D. 2006;7(2):87-97. Review.

PMID:
16542055
[PubMed - indexed for MEDLINE]
12.

Advances in gamma-secretase modulation.

Pissarnitski D.

Curr Opin Drug Discov Devel. 2007 Jul;10(4):392-402. Review. Erratum in: Curr Opin Drug Discov Devel. 2007 Nov;10(6):819.

PMID:
17659480
[PubMed - indexed for MEDLINE]
13.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

PMID:
19671883
[PubMed - indexed for MEDLINE]
Free Article
14.

Semagacestat, a gamma-secretase inhibitor for the potential treatment of Alzheimer's disease.

Imbimbo BP, Peretto I.

Curr Opin Investig Drugs. 2009 Jul;10(7):721-30.

PMID:
19579178
[PubMed - indexed for MEDLINE]
15.

[Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity].

Tomita T.

Rinsho Shinkeigaku. 2012;52(11):1165-7. Japanese.

PMID:
23196551
[PubMed - indexed for MEDLINE]
16.

Disease-modifying therapies in Alzheimer's disease: how far have we come?

Hüll M, Berger M, Heneka M.

Drugs. 2006;66(16):2075-93. Review.

PMID:
17112302
[PubMed - indexed for MEDLINE]
17.

[Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity].

Tomita T.

Rinsho Shinkeigaku. 2009 Nov;49(11):845-7. Review. Japanese.

PMID:
20030227
[PubMed - indexed for MEDLINE]
18.
19.

Gamma-secretase modulation and its promise for Alzheimer's disease: a rationale for drug discovery.

Beher D.

Curr Top Med Chem. 2008;8(1):34-7. Review.

PMID:
18220930
[PubMed - indexed for MEDLINE]
20.

Inhibition and modulation of gamma-secretase for Alzheimer's disease.

Wolfe MS.

Neurotherapeutics. 2008 Jul;5(3):391-8. doi: 10.1016/j.nurt.2008.05.010. Review.

PMID:
18625450
[PubMed - indexed for MEDLINE]
Free PMC Article

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