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The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.

Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E, Sprangers R.

EMBO J. 2012 Jan 18;31(2):279-90. doi: 10.1038/emboj.2011.408. Epub 2011 Nov 15.


Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes.

Tritschler F, Eulalio A, Helms S, Schmidt S, Coles M, Weichenrieder O, Izaurralde E, Truffault V.

Mol Cell Biol. 2008 Nov;28(21):6695-708. doi: 10.1128/MCB.00759-08. Epub 2008 Sep 2.


mRNA decapping is promoted by an RNA-binding channel in Dcp2.

Deshmukh MV, Jones BN, Quang-Dang DU, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD.

Mol Cell. 2008 Feb 15;29(3):324-36. doi: 10.1016/j.molcel.2007.11.027.


Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human.

Sakuno T, Araki Y, Ohya Y, Kofuji S, Takahashi S, Hoshino S, Katada T.

J Biochem. 2004 Dec;136(6):805-12. Erratum in: J Biochem (Tokyo). 2005 Mar;137(3):441.


A split active site couples cap recognition by Dcp2 to activation.

Floor SN, Jones BN, Hernandez GA, Gross JD.

Nat Struct Mol Biol. 2010 Sep;17(9):1096-101. doi: 10.1038/nsmb.1879. Epub 2010 Aug 15.


A divergent Sm fold in EDC3 proteins mediates DCP1 binding and P-body targeting.

Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O.

Mol Cell Biol. 2007 Dec;27(24):8600-11. Epub 2007 Oct 8.


New insights into the control of mRNA decapping.

Simon E, Camier S, Séraphin B.

Trends Biochem Sci. 2006 May;31(5):241-3. Epub 2006 Mar 31. Review.


Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.

Harigaya Y, Jones BN, Muhlrad D, Gross JD, Parker R.

Mol Cell Biol. 2010 Mar;30(6):1446-56. doi: 10.1128/MCB.01305-09. Epub 2010 Jan 19.


Decapping activators in Saccharomyces cerevisiae act by multiple mechanisms.

Nissan T, Rajyaguru P, She M, Song H, Parker R.

Mol Cell. 2010 Sep 10;39(5):773-83. doi: 10.1016/j.molcel.2010.08.025.


Interdomain dynamics and coactivation of the mRNA decapping enzyme Dcp2 are mediated by a gatekeeper tryptophan.

Floor SN, Borja MS, Gross JD.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2872-7. doi: 10.1073/pnas.1113620109. Epub 2012 Feb 9.


Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development.

Xu J, Yang JY, Niu QW, Chua NH.

Plant Cell. 2006 Dec;18(12):3386-98. Epub 2006 Dec 8.


Structural basis of dcp2 recognition and activation by dcp1.

She M, Decker CJ, Svergun DI, Round A, Chen N, Muhlrad D, Parker R, Song H.

Mol Cell. 2008 Feb 15;29(3):337-49. doi: 10.1016/j.molcel.2008.01.002.


A nuclear protein in Schizosaccharomyces pombe with homology to the human tumour suppressor Fhit has decapping activity.

Salehi Z, Geffers L, Vilela C, Birkenhäger R, Ptushkina M, Berthelot K, Ferro M, Gaskell S, Hagan I, Stapley B, McCarthy JE.

Mol Microbiol. 2002 Oct;46(1):49-62.


DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa.

Tritschler F, Braun JE, Motz C, Igreja C, Haas G, Truffault V, Izaurralde E, Weichenrieder O.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21591-6. doi: 10.1073/pnas.0909871106. Epub 2009 Dec 4.


A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5' exonucleolytic degradation.

Braun JE, Truffault V, Boland A, Huntzinger E, Chang CT, Haas G, Weichenrieder O, Coles M, Izaurralde E.

Nat Struct Mol Biol. 2012 Dec;19(12):1324-31. doi: 10.1038/nsmb.2413. Epub 2012 Nov 11.


Interactions between Upf1 and the decapping factors Edc3 and Pat1 in Saccharomyces cerevisiae.

Swisher KD, Parker R.

PLoS One. 2011;6(10):e26547. doi: 10.1371/journal.pone.0026547. Epub 2011 Oct 31.


Dcp1 links coactivators of mRNA decapping to Dcp2 by proline recognition.

Borja MS, Piotukh K, Freund C, Gross JD.

RNA. 2011 Feb;17(2):278-90. doi: 10.1261/rna.2382011. Epub 2010 Dec 10.


Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.

Wang CY, Chen WL, Wang SW.

Mol Cell Biol. 2013 Mar;33(6):1244-53. doi: 10.1128/MCB.01583-12. Epub 2013 Jan 14.


The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.

Braun JE, Tritschler F, Haas G, Igreja C, Truffault V, Weichenrieder O, Izaurralde E.

EMBO J. 2010 Jul 21;29(14):2368-80. doi: 10.1038/emboj.2010.124. Epub 2010 Jun 11.

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