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Results: 1 to 20 of 83

1.

CRLX101 (formerly IT-101)-A Novel Nanopharmaceutical of Camptothecin in Clinical Development.

Young C, Schluep T, Hwang J, Eliasof S.

Curr Bioact Compd. 2011 Mar;7(1):8-14.

PMID:
22081768
[PubMed]
Free PMC Article
2.

Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101.

Svenson S, Wolfgang M, Hwang J, Ryan J, Eliasof S.

J Control Release. 2011 Jul 15;153(1):49-55. doi: 10.1016/j.jconrel.2011.03.007. Epub 2011 Mar 23.

PMID:
21406204
[PubMed - indexed for MEDLINE]
Free Article
3.

Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells.

Minko T, Paranjpe PV, Qiu B, Lalloo A, Won R, Stein S, Sinko PJ.

Cancer Chemother Pharmacol. 2002 Aug;50(2):143-50. Epub 2002 Jun 11.

PMID:
12172980
[PubMed - indexed for MEDLINE]
4.

Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle.

Eliasof S, Lazarus D, Peters CG, Case RI, Cole RO, Hwang J, Schluep T, Chao J, Lin J, Yen Y, Han H, Wiley DT, Zuckerman JE, Davis ME.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15127-32. doi: 10.1073/pnas.1309566110. Epub 2013 Aug 26.

PMID:
23980155
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Comparative evaluation of polymeric and amphiphilic cyclodextrin nanoparticles for effective camptothecin delivery.

Cirpanli Y, Bilensoy E, Lale Doğan A, Caliş S.

Eur J Pharm Biopharm. 2009 Sep;73(1):82-9. doi: 10.1016/j.ejpb.2009.04.013. Epub 2009 May 13.

PMID:
19442723
[PubMed - indexed for MEDLINE]
6.

Pharmacodynamic and pharmacogenomic study of the nanoparticle conjugate of camptothecin CRLX101 for the treatment of cancer.

Gaur S, Wang Y, Kretzner L, Chen L, Yen T, Wu X, Yuan YC, Davis M, Yen Y.

Nanomedicine. 2014 Apr 22. pii: S1549-9634(14)00186-5. doi: 10.1016/j.nano.2014.04.003. [Epub ahead of print]

PMID:
24768630
[PubMed - as supplied by publisher]
7.

Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin.

Davis ME.

Adv Drug Deliv Rev. 2009 Nov 12;61(13):1189-92. doi: 10.1016/j.addr.2009.05.005. Epub 2009 Aug 12. Review.

PMID:
19682514
[PubMed - indexed for MEDLINE]
8.

Cyclodextrin complexation: influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent.

Kang J, Kumar V, Yang D, Chowdhury PR, Hohl RJ.

Eur J Pharm Sci. 2002 Mar;15(2):163-70.

PMID:
11849913
[PubMed - indexed for MEDLINE]
9.

Efficacy of camptothecin and polymer-conjugated camptothecin in tumor spheroids and solid tumors.

Ying V, Haverstick K, Page RL, Saltzman WM.

J Biomater Sci Polym Ed. 2007;18(10):1283-99.

PMID:
17939886
[PubMed - indexed for MEDLINE]
10.

Camptothecin in sterically stabilized phospholipid micelles: a novel nanomedicine.

Koo OM, Rubinstein I, Onyuksel H.

Nanomedicine. 2005 Mar;1(1):77-84. Erratum in: Nanomedicine. 2005 Jun;1(2):192.

PMID:
17292061
[PubMed - indexed for MEDLINE]
11.

Antitumor activity of beta-cyclodextrin polymer-camptothecin conjugates.

Cheng J, Khin KT, Davis ME.

Mol Pharm. 2004 May-Jun;1(3):183-93.

PMID:
15981921
[PubMed - indexed for MEDLINE]
12.

Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.

Sapra P, Zhao H, Mehlig M, Malaby J, Kraft P, Longley C, Greenberger LM, Horak ID.

Clin Cancer Res. 2008 Mar 15;14(6):1888-96. doi: 10.1158/1078-0432.CCR-07-4456.

PMID:
18347192
[PubMed - indexed for MEDLINE]
Free Article
13.

Drug product development and pharmacological evaluation of a sparingly soluble novel camptothecin analog for peroral administration.

Nekkanti V, Karatgi P, Paruchuri S, Pillai R.

Drug Deliv. 2011 May;18(4):294-303. doi: 10.3109/10717544.2010.544689. Epub 2011 Jan 10.

PMID:
21214430
[PubMed - indexed for MEDLINE]
14.

Preparation and antitumor characteristics of PLA/(PEG-PPG-PEG) nanoparticles loaded with camptothecin.

Kunii R, Onishi H, Machida Y.

Eur J Pharm Biopharm. 2007 Aug;67(1):9-17. Epub 2007 Jan 28.

PMID:
17337172
[PubMed - indexed for MEDLINE]
15.

Antitumoral activity of camptothecin-loaded nanoparticles in 9L rat glioma model.

Cırpanlı Y, Allard E, Passirani C, Bilensoy E, Lemaire L, Calış S, Benoit JP.

Int J Pharm. 2011 Jan 17;403(1-2):201-6. doi: 10.1016/j.ijpharm.2010.10.015. Epub 2010 Oct 15.

PMID:
20951783
[PubMed - indexed for MEDLINE]
16.

Particle characteristics and biodistribution of camptothecin-loaded PLA/(PEG-PPG-PEG) nanoparticles.

Kunii R, Onishi H, Ueki K, Koyama K, Machida Y.

Drug Deliv. 2008 Jan;15(1):3-10. doi: 10.1080/10717540701827154 .

PMID:
18197517
[PubMed - indexed for MEDLINE]
17.

Polymeric tubulysin-peptide nanoparticles with potent antitumor activity.

Schluep T, Gunawan P, Ma L, Jensen GS, Duringer J, Hinton S, Richter W, Hwang J.

Clin Cancer Res. 2009 Jan 1;15(1):181-9. doi: 10.1158/1078-0432.CCR-08-1848.

PMID:
19118045
[PubMed - indexed for MEDLINE]
Free Article
18.

Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.

Yu D, Peng P, Dharap SS, Wang Y, Mehlig M, Chandna P, Zhao H, Filpula D, Yang K, Borowski V, Borchard G, Zhang Z, Minko T.

J Control Release. 2005 Dec 10;110(1):90-102. Epub 2005 Nov 4.

PMID:
16271793
[PubMed - indexed for MEDLINE]
19.

XMT-1001, a novel polymeric camptothecin pro-drug in clinical development for patients with advanced cancer.

Yurkovetskiy AV, Fram RJ.

Adv Drug Deliv Rev. 2009 Nov 12;61(13):1193-202. doi: 10.1016/j.addr.2009.01.007. Epub 2009 Aug 12. Review.

PMID:
19682517
[PubMed - indexed for MEDLINE]
20.

Water-soluble poly-(L-glutamic acid)-Gly-camptothecin conjugates enhance camptothecin stability and efficacy in vivo.

Singer JW, Bhatt R, Tulinsky J, Buhler KR, Heasley E, Klein P, de Vries P.

J Control Release. 2001 Jul 6;74(1-3):243-7.

PMID:
11489501
[PubMed - indexed for MEDLINE]

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