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Items: 1 to 20 of 103


Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer.

Baumgart S, Glesel E, Singh G, Chen NM, Reutlinger K, Zhang J, Billadeau DD, Fernandez-Zapico ME, Gress TM, Singh SK, Ellenrieder V.

Gastroenterology. 2012 Feb;142(2):388-98.e1-7. doi: 10.1053/j.gastro.2011.11.001. Epub 2011 Nov 10.


NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells.

Köenig A, Linhart T, Schlengemann K, Reutlinger K, Wegele J, Adler G, Singh G, Hofmann L, Kunsch S, Büch T, Schäfer E, Gress TM, Fernandez-Zapico ME, Ellenrieder V.

Gastroenterology. 2010 Mar;138(3):1189-99.e1-2. doi: 10.1053/j.gastro.2009.10.045. Epub 2009 Nov 6.


Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.

Peng B, Fleming JB, Breslin T, Grau AM, Fojioka S, Abbruzzese JL, Evans DB, Ayers D, Wathen K, Wu T, Robertson KD, Chiao PJ.

Clin Cancer Res. 2002 Nov;8(11):3628-38.


Trisomy of the Dscr1 gene suppresses early progression of pancreatic intraepithelial neoplasia driven by oncogenic Kras.

Lee JC, Shin J, Baek KH.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):50-5. doi: 10.1016/j.bbrc.2013.09.033. Epub 2013 Sep 13.


WNT5A-NFAT signaling mediates resistance to apoptosis in pancreatic cancer.

Griesmann H, Ripka S, Pralle M, Ellenrieder V, Baumgart S, Buchholz M, Pilarsky C, Aust D, Gress TM, Michl P.

Neoplasia. 2013 Jan;15(1):11-22.


Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid.

Singh SK, Baumgart S, Singh G, König AO, Reutlinger K, Hofbauer LC, Barth P, Gress TM, Lomberk G, Urrutia R, Fernandez-Zapico ME, Ellenrieder V.

J Biol Chem. 2011 Aug 19;286(33):28761-71. doi: 10.1074/jbc.M110.197533. Epub 2011 May 31.


Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth.

Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, Van Seuningen I, Maitra A, Goggins M.

Oncotarget. 2014 May 15;5(9):2575-87.


GSK-3β governs inflammation-induced NFATc2 signaling hubs to promote pancreatic cancer progression.

Baumgart S, Chen NM, Zhang JS, Billadeau DD, Gaisina I, Kozikowski AP, Singh S, Fink D, Strobel P, Klindt C, Zhang L, Bamlet WR, Koenig A, Hessmann E, Gress T, Ellenrieder V, Neesse A.

Mol Cancer Ther. 2016 Jan 28. pii: molcanther.0309.2015. [Epub ahead of print]


Antibody against CD44s inhibits pancreatic tumor initiation and postradiation recurrence in mice.

Li L, Hao X, Qin J, Tang W, He F, Smith A, Zhang M, Simeone DM, Qiao XT, Chen ZN, Lawrence TS, Xu L.

Gastroenterology. 2014 Apr;146(4):1108-18. doi: 10.1053/j.gastro.2013.12.035. Epub 2014 Jan 5.


SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus.

Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP.

Mol Cell Biol. 2008 May;28(10):3457-64. doi: 10.1128/MCB.02019-07. Epub 2008 Mar 10.


Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer.

Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn CO, Heidecke CD, Friess H, Büchler M, Evert M, Lerch MM, Weiss FU.

Gut. 2012 Mar;61(3):439-48. doi: 10.1136/gutjnl-2011-300060. Epub 2011 Dec 5.


Phospho-sulindac inhibits pancreatic cancer growth: NFATc1 as a drug resistance candidate.

Murray OT, Wong CC, Vrankova K, Rigas B.

Int J Oncol. 2014 Feb;44(2):521-9. doi: 10.3892/ijo.2013.2190. Epub 2013 Nov 27.


KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer.

Abramovitz L, Rubinek T, Ligumsky H, Bose S, Barshack I, Avivi C, Kaufman B, Wolf I.

Clin Cancer Res. 2011 Jul 1;17(13):4254-66. doi: 10.1158/1078-0432.CCR-10-2749. Epub 2011 May 13.


Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16(INK4a) and p15(INK4b) cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells.

Muscarella P, Knobloch TJ, Ulrich AB, Casto BC, Moniaux N, Wittel UA, Melvin WS, Pour PM, Song H, Gold B, Batra SK, Weghorst CM.

Gene. 2001 Oct 31;278(1-2):235-43.


Oct-1 is involved in the transcriptional repression of the p15(INK4b) gene.

Hitomi T, Matsuzaki Y, Yasuda S, Kawanaka M, Yogosawa S, Koyama M, Tantin D, Sakai T.

FEBS Lett. 2007 Mar 20;581(6):1087-92. Epub 2007 Feb 14.


The p15(INK4b)/p16(INK4a)/RB1 pathway is frequently deregulated in human pituitary adenomas.

Ogino A, Yoshino A, Katayama Y, Watanabe T, Ota T, Komine C, Yokoyama T, Fukushima T.

J Neuropathol Exp Neurol. 2005 May;64(5):398-403.


E-cadherin regulates metastasis of pancreatic cancer in vivo and is suppressed by a SNAIL/HDAC1/HDAC2 repressor complex.

von Burstin J, Eser S, Paul MC, Seidler B, Brandl M, Messer M, von Werder A, Schmidt A, Mages J, Pagel P, Schnieke A, Schmid RM, Schneider G, Saur D.

Gastroenterology. 2009 Jul;137(1):361-71, 371.e1-5. doi: 10.1053/j.gastro.2009.04.004. Epub 2009 Apr 9.

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