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Items: 1 to 20 of 140

1.

p62 at the interface of autophagy, oxidative stress signaling, and cancer.

Nezis IP, Stenmark H.

Antioxid Redox Signal. 2012 Sep 1;17(5):786-93. doi: 10.1089/ars.2011.4394. Epub 2012 Jan 11. Review.

PMID:
22074114
2.

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

Jain A, Lamark T, Sjøttem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD, Johansen T.

J Biol Chem. 2010 Jul 16;285(29):22576-91. doi: 10.1074/jbc.M110.118976. Epub 2010 May 7.

3.

Keap1 degradation by autophagy for the maintenance of redox homeostasis.

Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7.

4.

A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.

Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD.

Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10. Epub 2010 Apr 26.

5.

New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.

Rea SL, Walsh JP, Layfield R, Ratajczak T, Xu J.

Endocr Rev. 2013 Aug;34(4):501-24. doi: 10.1210/er.2012-1034. Epub 2013 Apr 23. Review.

PMID:
23612225
6.

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

Katsuragi Y, Ichimura Y, Komatsu M.

FEBS J. 2015 Dec;282(24):4672-8. doi: 10.1111/febs.13540. Epub 2015 Oct 16. Review.

PMID:
26432171
7.

p62/SQSTM1/A170: physiology and pathology.

Komatsu M, Kageyama S, Ichimura Y.

Pharmacol Res. 2012 Dec;66(6):457-62. doi: 10.1016/j.phrs.2012.07.004. Epub 2012 Jul 25. Review.

PMID:
22841931
8.

SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1.

Darvekar SR, Elvenes J, Brenne HB, Johansen T, Sjøttem E.

PLoS One. 2014 Jan 9;9(1):e85262. doi: 10.1371/journal.pone.0085262. eCollection 2014.

9.

p62/Sequestosome-1, Autophagy-related Gene 8, and Autophagy in Drosophila Are Regulated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2), Independent of Transcription Factor TFEB.

Jain A, Rusten TE, Katheder N, Elvenes J, Bruun JA, Sjøttem E, Lamark T, Johansen T.

J Biol Chem. 2015 Jun 12;290(24):14945-62. doi: 10.1074/jbc.M115.656116. Epub 2015 Apr 30.

10.

Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1.

Gjyshi O, Flaherty S, Veettil MV, Johnson KE, Chandran B, Bottero V.

J Virol. 2015 Feb;89(4):2268-86. doi: 10.1128/JVI.02742-14. Epub 2014 Dec 10.

11.

Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.

Yin S, Cao W.

Mol Cell Biol. 2015 Aug;35(15):2673-83. doi: 10.1128/MCB.00105-15. Epub 2015 May 26.

12.

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.

Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M.

Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21.

PMID:
20173742
13.

Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity.

Park JS, Kang DH, Lee da H, Bae SH.

Biochem Biophys Res Commun. 2015 Oct 9;466(1):131-7. doi: 10.1016/j.bbrc.2015.08.120. Epub 2015 Aug 30.

PMID:
26325428
14.

Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.

Ishimura R, Tanaka K, Komatsu M.

FEBS Lett. 2014 Mar 3;588(5):822-8. doi: 10.1016/j.febslet.2014.01.045. Epub 2014 Feb 1.

15.

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis.

Stępkowski TM, Kruszewski MK.

Free Radic Biol Med. 2011 May 1;50(9):1186-95. doi: 10.1016/j.freeradbiomed.2011.01.033. Epub 2011 Feb 2.

PMID:
21295136
16.

The autophagy pathway maintained signaling crosstalk with the Keap1-Nrf2 system through p62 in auditory cells under oxidative stress.

Hayashi K, Dan K, Goto F, Tshuchihashi N, Nomura Y, Fujioka M, Kanzaki S, Ogawa K.

Cell Signal. 2015 Feb;27(2):382-93. doi: 10.1016/j.cellsig.2014.11.024. Epub 2014 Nov 28.

PMID:
25435427
17.

Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.

Mol Cell. 2013 Sep 12;51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5.

18.

p62/SQSTM1 is involved in cisplatin resistance in human ovarian cancer cells via the Keap1-Nrf2-ARE system.

Xia M, Yu H, Gu S, Xu Y, Su J, Li H, Kang J, Cui M.

Int J Oncol. 2014 Dec;45(6):2341-8. doi: 10.3892/ijo.2014.2669. Epub 2014 Sep 24.

PMID:
25269472
19.

p62 links autophagy and Nrf2 signaling.

Jiang T, Harder B, Rojo de la Vega M, Wong PK, Chapman E, Zhang DD.

Free Radic Biol Med. 2015 Nov;88(Pt B):199-204. doi: 10.1016/j.freeradbiomed.2015.06.014. Epub 2015 Jun 24. Review.

PMID:
26117325
20.

Sequestosome1/p62: a regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth.

Ishii T, Warabi E, Siow RC, Mann GE.

Free Radic Biol Med. 2013 Dec;65:102-16. doi: 10.1016/j.freeradbiomed.2013.06.019. Epub 2013 Jun 19. Review.

PMID:
23792273
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