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Results: 1 to 20 of 154

1.

Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.

Empey PE, Miller TM, Philbrick AH, Melick JA, Kochanek PM, Poloyac SM.

Crit Care Med. 2012 Apr;40(4):1221-8. doi: 10.1097/CCM.0b013e31823779f9.

PMID:
22067624
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model.

Tortorici MA, Kochanek PM, Bies RR, Poloyac SM.

Crit Care Med. 2006 Mar;34(3):785-91.

PMID:
16521272
[PubMed - indexed for MEDLINE]
3.

Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism.

Zhou J, Empey PE, Bies RR, Kochanek PM, Poloyac SM.

Drug Metab Dispos. 2011 Dec;39(12):2209-18. doi: 10.1124/dmd.111.040642. Epub 2011 Aug 25.

PMID:
21868471
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats.

Statler KD, Alexander HL, Vagni VA, Nemoto EM, Tofovic SP, Dixon CE, Jenkins LW, Marion DW, Kochanek PM.

Crit Care Med. 2003 Apr;31(4):1134-9.

PMID:
12682484
[PubMed - indexed for MEDLINE]
5.

A little hypothermia goes a long way.

Lee SA, Alston TA.

Crit Care Med. 2012 Apr;40(4):1369-70. doi: 10.1097/CCM.0b013e31823b8b6a. No abstract available.

PMID:
22425848
[PubMed - indexed for MEDLINE]
6.

The effect of mild hypothermia on plasma fentanyl concentration and biotransformation in juvenile pigs.

Fritz HG, Holzmayr M, Walter B, Moeritz KU, Lupp A, Bauer R.

Anesth Analg. 2005 Apr;100(4):996-1002.

PMID:
15781513
[PubMed - indexed for MEDLINE]
7.

Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.

Tortorici MA, Kochanek PM, Poloyac SM.

Crit Care Med. 2007 Sep;35(9):2196-204. Review.

PMID:
17855837
[PubMed - indexed for MEDLINE]
8.

Effects of hypothermia on the disposition of morphine, midazolam, fentanyl, and propofol in intensive care unit patients.

Bjelland TW, Klepstad P, Haugen BO, Nilsen T, Dale O.

Drug Metab Dispos. 2013 Jan;41(1):214-23. doi: 10.1124/dmd.112.045567. Epub 2012 Oct 31.

PMID:
23115086
[PubMed - indexed for MEDLINE]
Free Article
9.

Impact of therapeutic hypothermia onset and duration on survival, neurologic function, and neurodegeneration after cardiac arrest.

Che D, Li L, Kopil CM, Liu Z, Guo W, Neumar RW.

Crit Care Med. 2011 Jun;39(6):1423-30. doi: 10.1097/CCM.0b013e318212020a.

PMID:
21610611
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Population pharmacokinetics and metabolism of midazolam in pediatric intensive care patients.

de Wildt SN, de Hoog M, Vinks AA, van der Giesen E, van den Anker JN.

Crit Care Med. 2003 Jul;31(7):1952-8.

PMID:
12847388
[PubMed - indexed for MEDLINE]
11.

Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia.

Katz LM, Young A, Frank JE, Wang Y, Park K.

Crit Care Med. 2004 Mar;32(3):806-10.

PMID:
15090966
[PubMed - indexed for MEDLINE]
12.

Effect of borneol on cytochrome P450 3A enzyme and midazolam pharmacokinetics in rats.

Zhang R, Mi SQ, Wang NS.

Eur J Drug Metab Pharmacokinet. 2013 Sep;38(3):159-69. doi: 10.1007/s13318-013-0125-1. Epub 2013 Apr 16.

PMID:
23589122
[PubMed - indexed for MEDLINE]
13.

Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers.

Hostler D, Zhou J, Tortorici MA, Bies RR, Rittenberger JC, Empey PE, Kochanek PM, Callaway CW, Poloyac SM.

Drug Metab Dispos. 2010 May;38(5):781-8. doi: 10.1124/dmd.109.031377. Epub 2010 Feb 17.

PMID:
20164112
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats.

Higashikawa F, Murakami T, Kaneda T, Takano M.

J Pharm Pharmacol. 1999 Apr;51(4):405-10.

PMID:
10385212
[PubMed - indexed for MEDLINE]
15.

Hypothermia after cardiac arrest does not alter serum inflammatory markers.

Callaway CW, Rittenberger JC, Logue ES, McMichael MJ.

Crit Care Med. 2008 Sep;36(9):2607-12. doi: 10.1097/CCM.0b013e318184443b.

PMID:
18679114
[PubMed - indexed for MEDLINE]
16.

Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study.

Hamaoka N, Oda Y, Hase I, Mizutani K, Nakamoto T, Ishizaki T, Asada A.

Clin Pharmacol Ther. 1999 Aug;66(2):110-7.

PMID:
10460064
[PubMed - indexed for MEDLINE]
17.

Biphasic concentration change during continuous midazolam administration in brain-injured patients undergoing therapeutic moderate hypothermia.

Fukuoka N, Aibiki M, Tsukamoto T, Seki K, Morita S.

Resuscitation. 2004 Feb;60(2):225-30.

PMID:
15036742
[PubMed - indexed for MEDLINE]
18.

The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam.

Ibrahim A, Karim A, Feldman J, Kharasch E.

Anesth Analg. 2002 Sep;95(3):667-73, table of contents.

PMID:
12198057
[PubMed - indexed for MEDLINE]
19.

Pilot study of rapid infusion of 2 L of 4 degrees C normal saline for induction of mild hypothermia in hospitalized, comatose survivors of out-of-hospital cardiac arrest.

Kim F, Olsufka M, Carlbom D, Deem S, Longstreth WT Jr, Hanrahan M, Maynard C, Copass MK, Cobb LA.

Circulation. 2005 Aug 2;112(5):715-9. Epub 2005 Jul 25.

PMID:
16043638
[PubMed - indexed for MEDLINE]
Free Article
20.

Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs.

Fries M, Brücken A, Çizen A, Westerkamp M, Löwer C, Deike-Glindemann J, Schnorrenberger NK, Rex S, Coburn M, Nolte KW, Weis J, Rossaint R, Derwall M.

Crit Care Med. 2012 Apr;40(4):1297-303. doi: 10.1097/CCM.0b013e31823c8ce7.

PMID:
22425822
[PubMed - indexed for MEDLINE]

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