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Results: 1 to 20 of 132

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1.

Production of active human glucocerebrosidase in seeds of Arabidopsis thaliana complex-glycan-deficient (cgl) plants.

He X, Galpin JD, Tropak MB, Mahuran D, Haselhorst T, von Itzstein M, Kolarich D, Packer NH, Miao Y, Jiang L, Grabowski GA, Clarke LA, Kermode AR.

Glycobiology. 2012 Apr;22(4):492-503. doi: 10.1093/glycob/cwr157. Epub 2011 Nov 7.

2.

Tobacco seeds as efficient production platform for a biologically active anti-HBsAg monoclonal antibody.

Hernández-Velázquez A, López-Quesada A, Ceballo-Cámara Y, Cabrera-Herrera G, Tiel-González K, Mirabal-Ortega L, Pérez-Martínez M, Pérez-Castillo R, Rosabal-Ayán Y, Ramos-González O, Enríquez-Obregón G, Depicker A, Pujol-Ferrer M.

Transgenic Res. 2015 Jun 25. [Epub ahead of print]

PMID:
26109093
3.

Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells.

Ambrosi G, Ghezzi C, Zangaglia R, Levandis G, Pacchetti C, Blandini F.

Neurobiol Dis. 2015 Jun 19. pii: S0969-9961(15)00226-0. doi: 10.1016/j.nbd.2015.06.008. [Epub ahead of print]

PMID:
26094596
4.

The effects of chemically synthesized saposin C on glucosylceramide-β-glucosidase.

Yoneshige A, Muto M, Watanabe T, Hojo H, Matsuda J.

Clin Biochem. 2015 Jun 9. pii: S0009-9120(15)00217-9. doi: 10.1016/j.clinbiochem.2015.06.004. [Epub ahead of print]

PMID:
26068040
5.

Role of LIMP-2 in the intracellular trafficking of β-Glucosidase in different human cellular models.

Malini E, Zampieri S, Deganuto M, Romanello M, Sechi A, Bembi B, Dardis A.

FASEB J. 2015 May 27. pii: fj.15-271148. [Epub ahead of print]

PMID:
26018676
6.

Limited addition of the 6-arm β1,2-GlcNAc residue facilitates the formation of the largest N-glycan in plants.

Yoo JY, Ko KS, Seo HK, Park S, Fanata WI, Harmoko R, Ramasamy NK, Thulasinathan T, Mengiste T, Lim JM, Lee SY, Lee KO.

J Biol Chem. 2015 May 22. pii: jbc.M115.653162. [Epub ahead of print]

8.

Increased mannosylphosphorylation of N-glycans by heterologous expression of YlMPO1 in glyco-engineered Saccharomyces cerevisiae for mannose-6-phosphate modification.

Gil JY, Park JN, Lee KJ, Kang JY, Kim YH, Kim S, Kim SY, Kwon O, Lim YT, Kang HA, Oh DB.

J Biotechnol. 2015 Jul 20;206:66-74. doi: 10.1016/j.jbiotec.2015.04.007. Epub 2015 Apr 20.

PMID:
25907834
9.

Characterization of plants expressing the human β1,4-galactosyltrasferase gene.

Schneider J, Castilho A, Pabst M, Altmann F, Gruber C, Strasser R, Gattinger P, Seifert GJ, Steinkellner H.

Plant Physiol Biochem. 2015 Jul;92:39-47. doi: 10.1016/j.plaphy.2015.04.010. Epub 2015 Apr 13.

10.

Cancer: The complex seeds of metastasis.

Shen MM.

Nature. 2015 Apr 16;520(7547):298-9. doi: 10.1038/nature14377. Epub 2015 Apr 1. No abstract available.

PMID:
25830892
11.

Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation.

Bae EJ, Yang NY, Lee C, Lee HJ, Kim S, Sardi SP, Lee SJ.

Exp Mol Med. 2015 Mar 27;47:e153. doi: 10.1038/emm.2014.128.

12.

Tool compounds robustly increase turnover of an artificial substrate by glucocerebrosidase in human brain lysates.

Berger Z, Perkins S, Ambroise C, Oborski C, Calabrese M, Noell S, Riddell D, Hirst WD.

PLoS One. 2015 Mar 12;10(3):e0119141. doi: 10.1371/journal.pone.0119141. eCollection 2015.

13.

Comparison of VHH-Fc antibody production in Arabidopsis thaliana, Nicotiana benthamiana and Pichia pastoris.

De Meyer T, Laukens B, Nolf J, Van Lerberge E, De Rycke R, De Beuckelaer A, De Buck S, Callewaert N, Depicker A.

Plant Biotechnol J. 2015 Jan 30. doi: 10.1111/pbi.12330. [Epub ahead of print]

PMID:
25641071
14.

Effect of the developmental stage and tissue position on the expression and glycosylation of recombinant glycoprotein GA733-FcK in transgenic plants.

Lim CY, Lee KJ, Oh DB, Ko K.

Front Plant Sci. 2015 Jan 13;5:778. doi: 10.3389/fpls.2014.00778. eCollection 2014.

15.

Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C.

Gruschus JM, Jiang Z, Yap TL, Hill SA, Grishaev A, Piszczek G, Sidransky E, Lee JC.

Biochem Biophys Res Commun. 2015 Feb 20;457(4):561-6. doi: 10.1016/j.bbrc.2015.01.024. Epub 2015 Jan 17.

PMID:
25600808
16.

Fluorescence-quenched substrates for live cell imaging of human glucocerebrosidase activity.

Yadav AK, Shen DL, Shan X, He X, Kermode AR, Vocadlo DJ.

J Am Chem Soc. 2015 Jan 28;137(3):1181-9. doi: 10.1021/ja5106738. Epub 2015 Jan 15.

PMID:
25562638
17.

Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model.

Barnes S, Xu YH, Zhang W, Liou B, Setchell KD, Bao L, Grabowski GA, Sun Y.

PLoS One. 2014 Dec 31;9(12):e116023. doi: 10.1371/journal.pone.0116023. eCollection 2014.

18.

Conformationally-locked N-glycosides: exploiting long-range non-glycone interactions in the design of pharmacological chaperones for Gaucher disease.

Castilla J, Rísquez R, Higaki K, Nanba E, Ohno K, Suzuki Y, Díaz Y, Ortiz Mellet C, García Fernández JM, Castillón S.

Eur J Med Chem. 2015 Jan 27;90:258-66. doi: 10.1016/j.ejmech.2014.11.002. Epub 2014 Nov 4.

PMID:
25461326
19.

Trafficking of endoplasmic reticulum-retained recombinant proteins is unpredictable in Arabidopsis thaliana.

De Meyer T, Depicker A.

Front Plant Sci. 2014 Sep 15;5:473. doi: 10.3389/fpls.2014.00473. eCollection 2014. Review.

20.

The LIMP-2/SCARB2 binding motif on acid β-glucosidase: basic and applied implications for Gaucher disease and associated neurodegenerative diseases.

Liou B, Haffey WD, Greis KD, Grabowski GA.

J Biol Chem. 2014 Oct 24;289(43):30063-74. doi: 10.1074/jbc.M114.593616. Epub 2014 Sep 8.

PMID:
25202012
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