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Results: 1 to 20 of 105

1.

Anion activation site of insulin-degrading enzyme.

Noinaj N, Song ES, Bhasin S, Alper BJ, Schmidt WK, Hersh LB, Rodgers DW.

J Biol Chem. 2012 Jan 2;287(1):48-57. doi: 10.1074/jbc.M111.264614. Epub 2011 Nov 2.

PMID:
22049080
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE.

Im H, Manolopoulou M, Malito E, Shen Y, Zhao J, Neant-Fery M, Sun CY, Meredith SC, Sisodia SS, Leissring MA, Tang WJ.

J Biol Chem. 2007 Aug 31;282(35):25453-63. Epub 2007 Jul 5.

PMID:
17613531
[PubMed - indexed for MEDLINE]
Free Article
3.

Identification of the allosteric regulatory site of insulysin.

Noinaj N, Bhasin SK, Song ES, Scoggin KE, Juliano MA, Juliano L, Hersh LB, Rodgers DW.

PLoS One. 2011;6(6):e20864. doi: 10.1371/journal.pone.0020864. Epub 2011 Jun 24.

PMID:
21731629
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Structure based discovery of small molecules to regulate the activity of human insulin degrading enzyme.

Çakir B, Dağliyan O, Dağyildiz E, Bariş İ, Kavakli IH, Kizilel S, Türkay M.

PLoS One. 2012;7(2):e31787. doi: 10.1371/journal.pone.0031787. Epub 2012 Feb 15.

PMID:
22355395
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme.

McCord LA, Liang WG, Dowdell E, Kalas V, Hoey RJ, Koide A, Koide S, Tang WJ.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13827-32. doi: 10.1073/pnas.1304575110. Epub 2013 Aug 6.

PMID:
23922390
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development.

Song ES, Juliano MA, Juliano L, Hersh LB.

J Biol Chem. 2003 Dec 12;278(50):49789-94. Epub 2003 Oct 2.

PMID:
14527953
[PubMed - indexed for MEDLINE]
Free Article
7.

Characterization of the binding of the fluorescent ATP analog TNP-ATP to insulysin.

Yao H, Hersh LB.

Arch Biochem Biophys. 2006 Jul 15;451(2):175-81. Epub 2006 May 6.

PMID:
16723115
[PubMed - indexed for MEDLINE]
8.

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

Shen Y, Joachimiak A, Rosner MR, Tang WJ.

Nature. 2006 Oct 19;443(7113):870-4. Epub 2006 Oct 11.

PMID:
17051221
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Molecular basis for the recognition and cleavages of IGF-II, TGF-alpha, and amylin by human insulin-degrading enzyme.

Guo Q, Manolopoulou M, Bian Y, Schilling AB, Tang WJ.

J Mol Biol. 2010 Jan 15;395(2):430-43. doi: 10.1016/j.jmb.2009.10.072. Epub 2009 Nov 5.

PMID:
19896952
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

Malito E, Ralat LA, Manolopoulou M, Tsay JL, Wadlington NL, Tang WJ.

Biochemistry. 2008 Dec 2;47(48):12822-34. doi: 10.1021/bi801192h.

PMID:
18986166
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation.

Song ES, Cady C, Fried MG, Hersh LB.

Biochemistry. 2006 Dec 19;45(50):15085-91.

PMID:
17154546
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions.

Song ES, Daily A, Fried MG, Juliano MA, Juliano L, Hersh LB.

J Biol Chem. 2005 May 6;280(18):17701-6. Epub 2005 Mar 3.

PMID:
15749695
[PubMed - indexed for MEDLINE]
Free Article
13.

Elucidation of interactions of Alzheimer amyloid beta peptides (Abeta40 and Abeta42) with insulin degrading enzyme: a molecular dynamics study.

Bora RP, Prabhakar R.

Biochemistry. 2010 May 11;49(18):3947-56. doi: 10.1021/bi1002103.

PMID:
20380468
[PubMed - indexed for MEDLINE]
14.

Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation.

Song ES, Melikishvili M, Fried MG, Juliano MA, Juliano L, Rodgers DW, Hersh LB.

PLoS One. 2012;7(10):e46790. doi: 10.1371/journal.pone.0046790. Epub 2012 Oct 15.

PMID:
23077523
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Insulin-degrading enzyme hydrolyzes ATP.

Del Carmen Camberos M, Cresto JC.

Exp Biol Med (Maywood). 2007 Feb;232(2):281-92.

PMID:
17259336
[PubMed - indexed for MEDLINE]
16.

Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity.

Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M.

J Mol Biol. 2009 Feb 6;385(5):1556-67. doi: 10.1016/j.jmb.2008.11.025. Epub 2008 Nov 25.

PMID:
19073193
[PubMed - indexed for MEDLINE]
17.

Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease.

Fernández-Gamba A, Leal MC, Morelli L, Castaño EM.

Curr Pharm Des. 2009;15(31):3644-55. Review.

PMID:
19925417
[PubMed - indexed for MEDLINE]
18.

ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety.

Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB.

J Biol Chem. 2004 Dec 24;279(52):54216-20. Epub 2004 Oct 19.

PMID:
15494400
[PubMed - indexed for MEDLINE]
Free Article
19.

Yeast as a tractable genetic system for functional studies of the insulin-degrading enzyme.

Kim S, Lapham AN, Freedman CG, Reed TL, Schmidt WK.

J Biol Chem. 2005 Jul 29;280(30):27481-90. Epub 2005 Jun 8.

PMID:
15944156
[PubMed - indexed for MEDLINE]
Free Article
20.

Molecular basis for the thiol sensitivity of insulin-degrading enzyme.

Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9582-7. doi: 10.1073/pnas.0801261105. Epub 2008 Jul 8.

PMID:
18621727
[PubMed - indexed for MEDLINE]
Free PMC Article

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