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Items: 1 to 20 of 75

1.

The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis.

Cipriani S, Mencarelli A, Chini MG, Distrutti E, Renga B, Bifulco G, Baldelli F, Donini A, Fiorucci S.

PLoS One. 2011;6(10):e25637. doi: 10.1371/journal.pone.0025637. Epub 2011 Oct 27. Erratum in: PLoS One. 2013;8(1). doi:10.1371/annotation/55febddb-0209-4a48-9c14-23df882126a2.

2.

Stereoselective synthesis, biological evaluation, and modeling of novel bile acid-derived G-protein coupled bile acid receptor 1 (GP-BAR1, TGR5) agonists.

Yu DD, Sousa KM, Mattern DL, Wagner J, Fu X, Vaidehi N, Forman BM, Huang W.

Bioorg Med Chem. 2015 Apr 1;23(7):1613-28. doi: 10.1016/j.bmc.2015.01.048. Epub 2015 Feb 11.

PMID:
25735208
3.

Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.

Mencarelli A, Distrutti E, Renga B, D'Amore C, Cipriani S, Palladino G, Donini A, Ricci P, Fiorucci S.

PLoS One. 2011;6(7):e22978. doi: 10.1371/journal.pone.0022978. Epub 2011 Jul 29.

4.

Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice.

Zhao H, Zhang H, Wu H, Li H, Liu L, Guo J, Li C, Shih DQ, Zhang X.

BMC Gastroenterol. 2012 May 30;12:57.

5.

Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.

Gadaleta RM, van Erpecum KJ, Oldenburg B, Willemsen EC, Renooij W, Murzilli S, Klomp LW, Siersema PD, Schipper ME, Danese S, Penna G, Laverny G, Adorini L, Moschetta A, van Mil SW.

Gut. 2011 Apr;60(4):463-72. doi: 10.1136/gut.2010.212159. Epub 2011 Jan 17.

PMID:
21242261
6.

The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice.

Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura YI, Dohi T, Katsuno T, Yokosuka O, Waguri S, Ohno H.

Gastroenterology. 2011 Aug;141(2):621-32. doi: 10.1053/j.gastro.2011.04.056. Epub 2011 May 5.

PMID:
21669204
7.

Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).

Sepe V, Renga B, Festa C, D'Amore C, Masullo D, Cipriani S, Di Leva FS, Monti MC, Novellino E, Limongelli V, Zampella A, Fiorucci S.

J Med Chem. 2014 Sep 25;57(18):7687-701. doi: 10.1021/jm500889f. Epub 2014 Sep 7.

PMID:
25162837
8.

Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice.

Keates AC, Castagliuolo I, Cruickshank WW, Qiu B, Arseneau KO, Brazer W, Kelly CP.

Gastroenterology. 2000 Oct;119(4):972-82.

PMID:
11040184
9.

TWEAK/Fn14 pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis.

Dohi T, Borodovsky A, Wu P, Shearstone JR, Kawashima R, Runkel L, Rajman L, Dong X, Scott ML, Michaelson JS, Jakubowski A, Burkly LC.

Gastroenterology. 2009 Mar;136(3):912-23. doi: 10.1053/j.gastro.2008.11.017. Epub 2008 Nov 8.

PMID:
19109961
10.

A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis.

Boirivant M, Amendola A, Butera A, Sanchez M, Xu L, Marinaro M, Kitani A, Di Giacinto C, Strober W, Fuss IJ.

Gastroenterology. 2008 Nov;135(5):1612-1623.e5. doi: 10.1053/j.gastro.2008.07.028. Epub 2008 Aug 5.

PMID:
18765239
11.
12.

Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease.

Vetrano S, Rescigno M, Cera MR, Correale C, Rumio C, Doni A, Fantini M, Sturm A, Borroni E, Repici A, Locati M, Malesci A, Dejana E, Danese S.

Gastroenterology. 2008 Jul;135(1):173-84. doi: 10.1053/j.gastro.2008.04.002. Epub 2008 Apr 11.

PMID:
18514073
13.
14.

Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.

Mizoguchi E, Mizoguchi A, Takedatsu H, Cario E, de Jong YP, Ooi CJ, Xavier RJ, Terhorst C, Podolsky DK, Bhan AK.

Gastroenterology. 2002 Jan;122(1):134-44.

PMID:
11781288
15.

The bile acid receptor FXR is a modulator of intestinal innate immunity.

Vavassori P, Mencarelli A, Renga B, Distrutti E, Fiorucci S.

J Immunol. 2009 Nov 15;183(10):6251-61. doi: 10.4049/jimmunol.0803978. Epub 2009 Oct 28.

16.

Cholera toxin subunit B inhibits IL-12 and IFN-{gamma} production and signaling in experimental colitis and Crohn's disease.

Coccia EM, Remoli ME, Di Giacinto C, Del Zotto B, Giacomini E, Monteleone G, Boirivant M.

Gut. 2005 Nov;54(11):1558-64. Epub 2005 Aug 16.

17.

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier.

Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC.

Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G208-16. Epub 2007 Oct 25.

18.

Jα33+ MAIT cells play a protective role in TNBS induced intestinal inflammation.

Ruijing X, Mengjun W, Xiaoling Z, Shu P, Mei W, Yingcheng Z, Yuling H, Jinquan T.

Hepatogastroenterology. 2012 May;59(115):762-7. doi: 10.5754/hge11432.

PMID:
22115767
19.

Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis.

Mennigen R, Nolte K, Rijcken E, Utech M, Loeffler B, Senninger N, Bruewer M.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1140-9. doi: 10.1152/ajpgi.90534.2008. Epub 2009 Feb 12.

20.

Strategic compartmentalization of Toll-like receptor 4 in the mouse gut.

Ortega-Cava CF, Ishihara S, Rumi MA, Kawashima K, Ishimura N, Kazumori H, Udagawa J, Kadowaki Y, Kinoshita Y.

J Immunol. 2003 Apr 15;170(8):3977-85.

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