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Items: 1 to 20 of 87

1.

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity.

Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):E1120-7. doi: 10.1073/pnas.1109879108. Epub 2011 Oct 26.

2.

Akt1 mediates purinergic-dependent NOS3 activation in thick ascending limbs.

Silva GB, Garvin JL.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F646-52. doi: 10.1152/ajprenal.00270.2009. Epub 2009 Jul 1.

3.

Akt kinase C-terminal modifications control activation loop dephosphorylation and enhance insulin response.

Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB.

Biochem J. 2015 Oct 1;471(1):37-51. doi: 10.1042/BJ20150325. Epub 2015 Jul 22.

4.

The Mechanism of ATP-Dependent Allosteric Protection of Akt Kinase Phosphorylation.

Lu S, Deng R, Jiang H, Song H, Li S, Shen Q, Huang W, Nussinov R, Yu J, Zhang J.

Structure. 2015 Sep 1;23(9):1725-34. doi: 10.1016/j.str.2015.06.027. Epub 2015 Aug 6.

PMID:
26256536
5.

Autoregulation of kinase dephosphorylation by ATP binding in AGC protein kinases.

Chan TO, Pascal JM, Armen RS, Rodeck U.

Cell Cycle. 2012 Feb 1;11(3):475-8. doi: 10.4161/cc.11.3.19059. Epub 2012 Feb 1. Review.

6.

Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines.

Toral-Barza L, Zhang WG, Huang X, McDonald LA, Salaski EJ, Barbieri LR, Ding WD, Krishnamurthy G, Hu YB, Lucas J, Bernan VS, Cai P, Levin JI, Mansour TS, Gibbons JJ, Abraham RT, Yu K.

Mol Cancer Ther. 2007 Nov;6(11):3028-38. Epub 2007 Nov 7.

7.

Purinergic receptor-mediated rapid depletion of nuclear phosphorylated Akt depends on pleckstrin homology domain leucine-rich repeat phosphatase, calcineurin, protein phosphatase 2A, and PTEN phosphatases.

Mistafa O, Ghalali A, Kadekar S, Högberg J, Stenius U.

J Biol Chem. 2010 Sep 3;285(36):27900-10. doi: 10.1074/jbc.M110.117093. Epub 2010 Jul 6.

8.

Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes.

Chen CS, Weng SC, Tseng PH, Lin HP, Chen CS.

J Biol Chem. 2005 Nov 18;280(46):38879-87. Epub 2005 Sep 26.

9.

An ATP-site on-off switch that restricts phosphatase accessibility of Akt.

Lin K, Lin J, Wu WI, Ballard J, Lee BB, Gloor SL, Vigers GP, Morales TH, Friedman LS, Skelton N, Brandhuber BJ.

Sci Signal. 2012 May 8;5(223):ra37. doi: 10.1126/scisignal.2002618.

10.

Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.

Cell Signal. 2007 Dec;19(12):2444-57. Epub 2007 Aug 3.

PMID:
17826953
11.
12.

Akt2, a novel functional link between p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in myogenesis.

Gonzalez I, Tripathi G, Carter EJ, Cobb LJ, Salih DA, Lovett FA, Holding C, Pell JM.

Mol Cell Biol. 2004 May;24(9):3607-22.

13.

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.

Barnett SF, Defeo-Jones D, Fu S, Hancock PJ, Haskell KM, Jones RE, Kahana JA, Kral AM, Leander K, Lee LL, Malinowski J, McAvoy EM, Nahas DD, Robinson RG, Huber HE.

Biochem J. 2005 Jan 15;385(Pt 2):399-408.

14.

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

Pankov R, Cukierman E, Clark K, Matsumoto K, Hahn C, Poulin B, Yamada KM.

J Biol Chem. 2003 May 16;278(20):18671-81. Epub 2003 Mar 11.

15.

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N.

J Biol Chem. 2005 Sep 16;280(37):32081-9. Epub 2005 Jul 15.

16.

The molecular mechanism underlying morphine-induced Akt activation: roles of protein phosphatases and reactive oxygen species.

Xu J, Tian W, Ma X, Guo J, Shi Q, Jin Y, Xi J, Xu Z.

Cell Biochem Biophys. 2011 Nov;61(2):303-11. doi: 10.1007/s12013-011-9213-5.

PMID:
21626435
17.

N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A.

Yellaturu CR, Bhanoori M, Neeli I, Rao GN.

J Biol Chem. 2002 Oct 18;277(42):40148-55. Epub 2002 Aug 8.

18.

Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.

Piwien-Pilipuk G, Van Mater D, Ross SE, MacDougald OA, Schwartz J.

J Biol Chem. 2001 Jun 1;276(22):19664-71. Epub 2001 Mar 13.

20.

Turn motif phosphorylation negatively regulates activation loop phosphorylation in Akt.

Hiraoka D, Okumura E, Kishimoto T.

Oncogene. 2011 Nov 3;30(44):4487-97. doi: 10.1038/onc.2011.155. Epub 2011 May 16.

PMID:
21577208
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