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Results: 1 to 20 of 97

1.

Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition.

Höglund A, Strömvall K, Li Y, Forshell LP, Nilsson JA.

Cell Cycle. 2011 Oct 15;10(20):3598-607. doi: 10.4161/cc.10.20.17887. Epub 2011 Oct 15.

PMID:
22030621
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

MYC regulation of CHK1 and CHK2 promotes radioresistance in a stem cell-like population of nasopharyngeal carcinoma cells.

Wang WJ, Wu SP, Liu JB, Shi YS, Huang X, Zhang QB, Yao KT.

Cancer Res. 2013 Feb 1;73(3):1219-31. doi: 10.1158/0008-5472.CAN-12-1408. Epub 2012 Dec 26.

PMID:
23269272
[PubMed - indexed for MEDLINE]
Free Article
3.

Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells.

Ferrao PT, Bukczynska EP, Johnstone RW, McArthur GA.

Oncogene. 2012 Mar 29;31(13):1661-72. doi: 10.1038/onc.2011.358. Epub 2011 Aug 15.

PMID:
21841818
[PubMed - indexed for MEDLINE]
4.

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.

Smith J, Tho LM, Xu N, Gillespie DA.

Adv Cancer Res. 2010;108:73-112. doi: 10.1016/B978-0-12-380888-2.00003-0. Review.

PMID:
21034966
[PubMed - indexed for MEDLINE]
5.

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1446-51. Epub 2006 Jan 23.

PMID:
16432227
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication.

Cannell IG, Kong YW, Johnston SJ, Chen ML, Collins HM, Dobbyn HC, Elia A, Kress TR, Dickens M, Clemens MJ, Heery DM, Gaestel M, Eilers M, Willis AE, Bushell M.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5375-80. doi: 10.1073/pnas.0910015107. Epub 2010 Mar 8.

PMID:
20212154
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Morgan MA, Parsels LA, Zhao L, Parsels JD, Davis MA, Hassan MC, Arumugarajah S, Hylander-Gans L, Morosini D, Simeone DM, Canman CE, Normolle DP, Zabludoff SD, Maybaum J, Lawrence TS.

Cancer Res. 2010 Jun 15;70(12):4972-81. doi: 10.1158/0008-5472.CAN-09-3573. Epub 2010 May 25.

PMID:
20501833
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks.

Heacock ML, Stefanick DF, Horton JK, Wilson SH.

DNA Repair (Amst). 2010 Aug 5;9(8):929-36. doi: 10.1016/j.dnarep.2010.05.007. Epub 2010 Jun 22.

PMID:
20573551
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis.

Maclean KH, Kastan MB, Cleveland JL.

Mol Cancer Res. 2007 Jul;5(7):705-11.

PMID:
17634425
[PubMed - indexed for MEDLINE]
Free Article
10.

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

Urist M, Tanaka T, Poyurovsky MV, Prives C.

Genes Dev. 2004 Dec 15;18(24):3041-54.

PMID:
15601819
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

PARP inhibition during alkylation-induced genotoxic stress signals a cell cycle checkpoint response mediated by ATM.

Carrozza MJ, Stefanick DF, Horton JK, Kedar PS, Wilson SH.

DNA Repair (Amst). 2009 Nov 2;8(11):1264-72. doi: 10.1016/j.dnarep.2009.07.010. Epub 2009 Aug 31.

PMID:
19717351
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Potentiation of the novel topoisomerase I inhibitor indenoisoquinoline LMP-400 by the cell checkpoint and Chk1-Chk2 inhibitor AZD7762.

Aris SM, Pommier Y.

Cancer Res. 2012 Feb 15;72(4):979-89. doi: 10.1158/0008-5472.CAN-11-2579. Epub 2011 Dec 21. Erratum in: Cancer Res. 2012 Apr 15;72(8):2153-4.

PMID:
22189968
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells.

Höglund A, Nilsson LM, Muralidharan SV, Hasvold LA, Merta P, Rudelius M, Nikolova V, Keller U, Nilsson JA.

Clin Cancer Res. 2011 Nov 15;17(22):7067-79. doi: 10.1158/1078-0432.CCR-11-1198. Epub 2011 Sep 20.

PMID:
21933891
[PubMed - indexed for MEDLINE]
Free Article
14.

CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors.

Anderson VE, Walton MI, Eve PD, Boxall KJ, Antoni L, Caldwell JJ, Aherne W, Pearl LH, Oliver AW, Collins I, Garrett MD.

Cancer Res. 2011 Jan 15;71(2):463-72. doi: 10.1158/0008-5472.CAN-10-1252.

PMID:
21239475
[PubMed - indexed for MEDLINE]
Free Article
15.

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.

den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, Hoellein A, Kremer M, Graf N, Scheerer M, Hall MA, Goga A, von Bubnoff N, Duyster J, Peschel C, Cleveland JL, Nilsson JA, Keller U.

Blood. 2010 Sep 2;116(9):1498-505. doi: 10.1182/blood-2009-11-251074. Epub 2010 Jun 2.

PMID:
20519624
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.

Bryant HE, Helleday T.

Nucleic Acids Res. 2006 Mar 23;34(6):1685-91. Print 2006.

PMID:
16556909
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability.

Menssen A, Epanchintsev A, Lodygin D, Rezaei N, Jung P, Verdoodt B, Diebold J, Hermeking H.

Cell Cycle. 2007 Feb 1;6(3):339-52. Epub 2007 Feb 3.

PMID:
17297307
[PubMed - indexed for MEDLINE]
Free Article
18.

Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line.

Biliran H Jr, Wang Y, Banerjee S, Xu H, Heng H, Thakur A, Bollig A, Sarkar FH, Liao JD.

Clin Cancer Res. 2005 Aug 15;11(16):6075-86.

PMID:
16115953
[PubMed - indexed for MEDLINE]
Free Article
19.

Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.

Nguyen D, Zajac-Kaye M, Rubinstein L, Voeller D, Tomaszewski JE, Kummar S, Chen AP, Pommier Y, Doroshow JH, Yang SX.

Cell Cycle. 2011 Dec 1;10(23):4074-82. doi: 10.4161/cc.10.23.18170. Epub 2011 Dec 1.

PMID:
22101337
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.

Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, Kato N.

J Virol. 2008 Oct;82(19):9639-46. doi: 10.1128/JVI.00351-08. Epub 2008 Jul 30.

PMID:
18667510
[PubMed - indexed for MEDLINE]
Free PMC Article

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