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Results: 1 to 20 of 80

1.

CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases.

Cederbaum AI, Yang L, Wang X, Wu D.

Int J Hepatol. 2012;2012:582790. doi: 10.1155/2012/582790. Epub 2011 Oct 18.

PMID:
22028977
[PubMed]
Free PMC Article
2.
3.

Synergistic Toxic Interactions Between CYP2E1, LPS/TNFα, and JNK/p38 MAP Kinase and Their Implications in Alcohol-Induced Liver Injury.

Cederbaum AI, Lu Y, Wang X, Wu D.

Adv Exp Med Biol. 2015;815:145-72. doi: 10.1007/978-3-319-09614-8_9.

PMID:
25427906
[PubMed - in process]
4.

Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury.

Wu D, Cederbaum A.

Free Radic Biol Med. 2010 Aug 1;49(3):348-60. doi: 10.1016/j.freeradbiomed.2010.04.021. Epub 2010 May 14.

PMID:
20438834
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Role of nitric oxide and nuclear factor-kappaB in the CYP2E1 potentiation of tumor necrosis factor alpha hepatotoxicity in mice.

Wu D, Xu C, Cederbaum A.

Free Radic Biol Med. 2009 Feb 15;46(4):480-91. doi: 10.1016/j.freeradbiomed.2008.11.001. Epub 2008 Nov 19.

PMID:
19063961
[PubMed - indexed for MEDLINE]
7.

Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells.

Yang L, Wu D, Wang X, Cederbaum AI.

Free Radic Biol Med. 2011 Jul 1;51(1):185-96. doi: 10.1016/j.freeradbiomed.2011.04.030. Epub 2011 Apr 22.

PMID:
21557999
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase.

Wang X, Lu Y, Xie B, Cederbaum AI.

Free Radic Biol Med. 2009 Sep 1;47(5):518-28. doi: 10.1016/j.freeradbiomed.2009.05.021. Epub 2009 May 27.

PMID:
19477265
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Nitric oxide donors prevent while the nitric oxide synthase inhibitor L-NAME increases arachidonic acid plus CYP2E1-dependent toxicity.

Wu D, Cederbaum A.

Toxicol Appl Pharmacol. 2006 Oct 15;216(2):282-92. Epub 2006 Jul 1.

PMID:
16938321
[PubMed - indexed for MEDLINE]
10.

Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1.

Wu D, Cederbaum AI.

Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):70-6. Review.

PMID:
16019049
[PubMed - indexed for MEDLINE]
11.

Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice.

Zhuge J, Cederbaum AI.

Free Radic Biol Med. 2009 Feb 1;46(3):406-13. doi: 10.1016/j.freeradbiomed.2008.10.037. Epub 2008 Oct 31.

PMID:
19026739
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway.

Gong P, Cederbaum AI, Nieto N.

J Biol Chem. 2003 Aug 8;278(32):29693-700. Epub 2003 May 30.

PMID:
12777398
[PubMed - indexed for MEDLINE]
Free Article
13.

CYP2E1-dependent toxicity and oxidative stress in HepG2 cells.

Cederbaum AI, Wu D, Mari M, Bai J.

Free Radic Biol Med. 2001 Dec 15;31(12):1539-43. Review.

PMID:
11744327
[PubMed - indexed for MEDLINE]
14.

Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole.

Lu Y, Wang X, Cederbaum AI.

Am J Physiol Gastrointest Liver Physiol. 2005 Aug;289(2):G308-19. Epub 2005 Apr 21.

PMID:
15845871
[PubMed - indexed for MEDLINE]
Free Article
15.

Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways.

Wang X, Cederbaum AI.

Free Radic Biol Med. 2007 Apr 1;42(7):971-84. Epub 2006 Dec 22.

PMID:
17349925
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation.

Koteish A, Yang S, Lin H, Huang X, Diehl AM.

J Biol Chem. 2002 Apr 12;277(15):13037-44. Epub 2002 Jan 25.

PMID:
11812769
[PubMed - indexed for MEDLINE]
Free Article
17.

Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK.

Wu D, Cederbaum AI.

Redox Biol. 2013 Nov 5;1:552-65. doi: 10.1016/j.redox.2013.10.008. eCollection 2013.

PMID:
24273738
[PubMed - in process]
Free PMC Article
18.

Nrf2 and antioxidant defense against CYP2E1 toxicity.

Cederbaum A.

Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1223-44. doi: 10.1517/17425250903143769. Review.

PMID:
19671018
[PubMed - indexed for MEDLINE]
19.

Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells.

Pérez MJ, Cederbaum AI.

Hepatology. 2003 Jun;37(6):1395-404.

PMID:
12774019
[PubMed - indexed for MEDLINE]
20.

Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis.

Nagata K, Suzuki H, Sakaguchi S.

J Toxicol Sci. 2007 Dec;32(5):453-68. Review.

PMID:
18198478
[PubMed - indexed for MEDLINE]
Free Article

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