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Items: 1 to 20 of 86


The Type VI secretion system of Burkholderia cenocepacia affects multiple Rho family GTPases disrupting the actin cytoskeleton and the assembly of NADPH oxidase complex in macrophages.

Rosales-Reyes R, Skeldon AM, Aubert DF, Valvano MA.

Cell Microbiol. 2012 Feb;14(2):255-73. doi: 10.1111/j.1462-5822.2011.01716.x. Epub 2011 Nov 15.


Burkholderia cenocepacia disrupts host cell actin cytoskeleton by inactivating Rac and Cdc42.

Flannagan RS, Jaumouillé V, Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S.

Cell Microbiol. 2012 Feb;14(2):239-54. doi: 10.1111/j.1462-5822.2011.01715.x. Epub 2011 Nov 15.


Burkholderia cenocepacia type VI secretion system mediates escape of type II secreted proteins into the cytoplasm of infected macrophages.

Rosales-Reyes R, Aubert DF, Tolman JS, Amer AO, Valvano MA.

PLoS One. 2012;7(7):e41726. doi: 10.1371/journal.pone.0041726. Epub 2012 Jul 25.


Delayed association of the NADPH oxidase complex with macrophage vacuoles containing the opportunistic pathogen Burkholderia cenocepacia.

Keith KE, Hynes DW, Sholdice JE, Valvano MA.

Microbiology. 2009 Apr;155(Pt 4):1004-15. doi: 10.1099/mic.0.026781-0.


Burkholderia cenocepacia infection: disruption of phagocyte immune functions through Rho GTPase inactivation.

Flannagan RS.

Cell Adh Migr. 2012 Jul-Aug;6(4):297-301. doi: 10.4161/cam.20487. Epub 2012 May 24.


Ras-related GTPases and the cytoskeleton.

Hall A.

Mol Biol Cell. 1992 May;3(5):475-9. Review.


Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells.

Wojciak-Stothard B, Tsang LY, Haworth SG.

Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L749-60. Epub 2004 Dec 10.


BcsKC is an essential protein for the type VI secretion system activity in Burkholderia cenocepacia that forms an outer membrane complex with BcsLB.

Aubert D, MacDonald DK, Valvano MA.

J Biol Chem. 2010 Nov 12;285(46):35988-98. doi: 10.1074/jbc.M110.120402. Epub 2010 Aug 20.


Inactivation of macrophage Rab7 by Burkholderia cenocepacia.

Huynh KK, Plumb JD, Downey GP, Valvano MA, Grinstein S.

J Innate Immun. 2010;2(6):522-33. doi: 10.1159/000319864. Epub 2010 Sep 10.


Plexin-B semaphorin receptors interact directly with active Rac and regulate the actin cytoskeleton by activating Rho.

Driessens MH, Hu H, Nobes CD, Self A, Jordens I, Goodman CS, Hall A.

Curr Biol. 2001 Mar 6;11(5):339-44.


A novel sensor kinase-response regulator hybrid controls biofilm formation and type VI secretion system activity in Burkholderia cenocepacia.

Aubert DF, Flannagan RS, Valvano MA.

Infect Immun. 2008 May;76(5):1979-91. doi: 10.1128/IAI.01338-07. Epub 2008 Mar 3.


Mechanism of NADPH oxidase activation by the Rac/Rho-GDI complex.

Di-Poï N, Fauré J, Grizot S, Molnár G, Pick E, Dagher MC.

Biochemistry. 2001 Aug 28;40(34):10014-22.


Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.

J Biol Chem. 2004 Jan 30;279(5):3777-86. Epub 2003 Nov 3.


Antagonistic cross-talk between Rac and Cdc42 GTPases regulates generation of reactive oxygen species.

Diebold BA, Fowler B, Lu J, Dinauer MC, Bokoch GM.

J Biol Chem. 2004 Jul 2;279(27):28136-42. Epub 2004 May 3.


A role of STAT3 in Rho GTPase-regulated cell migration and proliferation.

Debidda M, Wang L, Zang H, Poli V, Zheng Y.

J Biol Chem. 2005 Apr 29;280(17):17275-85. Epub 2005 Feb 10.


G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.

Niu J, Profirovic J, Pan H, Vaiskunaite R, Voyno-Yasenetskaya T.

Circ Res. 2003 Oct 31;93(9):848-56. Epub 2003 Sep 25.


Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.

Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K.

Biochemistry. 1998 Apr 14;37(15):5296-304.

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