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Results: 1 to 20 of 116

1.

p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors.

Fransson S, Uv A, Eriksson H, Andersson MK, Wettergren Y, Bergo M, Ejeskär K.

Oncogene. 2012 Jul 5;31(27):3277-86. doi: 10.1038/onc.2011.492. Epub 2011 Oct 24.

PMID:
22020336
[PubMed - indexed for MEDLINE]
2.

High level of p37δ-mRNA relative to p110δ-mRNA in neuroblastoma tumors correlates with poor patient survival.

Fransson S, Ejeskär K.

Med Oncol. 2013 Dec;30(4):724. doi: 10.1007/s12032-013-0724-3. Epub 2013 Sep 12.

PMID:
24026661
[PubMed - indexed for MEDLINE]
3.
4.

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

Carón RW, Yacoub A, Zhu X, Mitchell C, Han SI, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P.

Mol Cancer Ther. 2005 Feb;4(2):243-55.

PMID:
15713896
[PubMed - indexed for MEDLINE]
Free Article
5.

The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.

Jimenez C, Hernandez C, Pimentel B, Carrera AC.

J Biol Chem. 2002 Nov 1;277(44):41556-62. Epub 2002 Aug 23.

PMID:
12196526
[PubMed - indexed for MEDLINE]
Free Article
6.

The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion.

Luk SK, Piekorz RP, Nürnberg B, Tony To SS.

Eur J Cancer. 2012 Jan;48(1):149-57. doi: 10.1016/j.ejca.2011.09.006. Epub 2011 Nov 11.

PMID:
22079609
[PubMed - indexed for MEDLINE]
7.

Overexpression of 14-3-3ζ in cancer cells activates PI3K via binding the p85 regulatory subunit.

Neal CL, Xu J, Li P, Mori S, Yang J, Neal NN, Zhou X, Wyszomierski SL, Yu D.

Oncogene. 2012 Feb 16;31(7):897-906. doi: 10.1038/onc.2011.284. Epub 2011 Jul 11.

PMID:
21743495
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.

Rusyn EV, Reynolds ER, Shao H, Grana TM, Chan TO, Andres DA, Cox AD.

Oncogene. 2000 Sep 28;19(41):4685-94.

PMID:
11032018
[PubMed - indexed for MEDLINE]
Free Article
9.

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.

Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B.

Biochem J. 2012 May 1;443(3):857-67. doi: 10.1042/BJ20112214.

PMID:
22375552
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras.

Akagi T, Murata K, Shishido T, Hanafusa H.

Mol Cell Biol. 2002 Oct;22(20):7015-23.

PMID:
12242282
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway.

Meng Q, Xia C, Fang J, Rojanasakul Y, Jiang BH.

Cell Signal. 2006 Dec;18(12):2262-71. Epub 2006 Jun 2.

PMID:
16839745
[PubMed - indexed for MEDLINE]
12.

P110delta, a novel phosphoinositide 3-kinase in leukocytes.

Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4330-5.

PMID:
9113989
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Phosphoinositide 3-kinase targeting by the beta galactoside binding protein cytokine negates akt gene expression and leads aggressive breast cancer cells to apoptotic death.

Wells V, Mallucci L.

Breast Cancer Res. 2009;11(1):R2. doi: 10.1186/bcr2217. Epub 2009 Jan 8.

PMID:
19133120
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation.

Damiano L, Di Stefano P, Camacho Leal MP, Barba M, Mainiero F, Cabodi S, Tordella L, Sapino A, Castellano I, Canel M, Frame M, Turco E, Defilippi P.

Oncogene. 2010 Jun 24;29(25):3677-90. doi: 10.1038/onc.2010.128. Epub 2010 May 10.

PMID:
20453886
[PubMed - indexed for MEDLINE]
15.

Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia.

Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick JS, Prie N, Verdier F, Vanhaesebroeck B, Muller O, Pesce F, Ifrah N, Hunault-Berger M, Berthou C, Villemagne B, Jourdan E, Audhuy B, Solary E, Witz B, Harousseau JL, Himberlin C, Lamy T, Lioure B, Cahn JY, Dreyfus F, Mayeux P, Lacombe C, Bouscary D.

Blood. 2005 Aug 1;106(3):1063-6. Epub 2005 Apr 19.

PMID:
15840695
[PubMed - indexed for MEDLINE]
Free Article
16.

Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits.

Jiang X, Chen S, Asara JM, Balk SP.

J Biol Chem. 2010 May 14;285(20):14980-9. doi: 10.1074/jbc.M109.085696. Epub 2010 Mar 15.

PMID:
20231295
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Oncogenic signaling of class I PI3K isoforms.

Denley A, Kang S, Karst U, Vogt PK.

Oncogene. 2008 Apr 17;27(18):2561-74. Epub 2007 Nov 12.

PMID:
17998941
[PubMed - indexed for MEDLINE]
18.

Manumycin inhibits cell proliferation and the Ras signal transduction pathway in human hepatocellular carcinoma cells.

Zhou JM, Zhu XF, Pan QC, Liao DF, Li ZM, Liu ZC.

Int J Mol Med. 2003 Jun;11(6):767-71.

PMID:
12736720
[PubMed - indexed for MEDLINE]
19.

Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway.

Chang MC, Chen CA, Hsieh CY, Lee CN, Su YN, Hu YH, Cheng WF.

Biochem J. 2009 Dec 10;424(3):449-58. doi: 10.1042/BJ20082196.

PMID:
19747165
[PubMed - indexed for MEDLINE]
Free Article
20.

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.

Balmanno K, Chell SD, Gillings AS, Hayat S, Cook SJ.

Int J Cancer. 2009 Nov 15;125(10):2332-41. doi: 10.1002/ijc.24604.

PMID:
19637312
[PubMed - indexed for MEDLINE]

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