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Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action.

Thompson CM, Proctor DM, Suh M, Haws LC, Hébert CD, Mann JF, Shertzer HG, Hixon JG, Harris MA.

Toxicol Sci. 2012 Jan;125(1):79-90. doi: 10.1093/toxsci/kfr280. Epub 2011 Oct 19.


Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium.

Thompson CM, Proctor DM, Haws LC, Hébert CD, Grimes SD, Shertzer HG, Kopec AK, Hixon JG, Zacharewski TR, Harris MA.

Toxicol Sci. 2011 Sep;123(1):58-70. doi: 10.1093/toxsci/kfr164. Epub 2011 Jun 28.


Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water.

Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM, Harris MA, Haws LC, Thompson CM.

Toxicol Appl Pharmacol. 2012 Feb 15;259(1):13-26. doi: 10.1016/j.taap.2011.11.012. Epub 2011 Dec 1.


Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia.

Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR.

Toxicol Appl Pharmacol. 2012 Jul 15;262(2):124-38. doi: 10.1016/j.taap.2012.04.026. Epub 2012 Apr 28.


Hexavalent chromium is carcinogenic to F344/N rats and B6C3F1 mice after chronic oral exposure.

Stout MD, Herbert RA, Kissling GE, Collins BJ, Travlos GS, Witt KL, Melnick RL, Abdo KM, Malarkey DE, Hooth MJ.

Environ Health Perspect. 2009 May;117(5):716-22. doi: 10.1289/ehp.0800208. Epub 2008 Dec 31.


High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice.

Suh M, Thompson CM, Kirman CR, Carakostas MC, Haws LC, Harris MA, Proctor DM.

Food Chem Toxicol. 2014 Mar;65:381-8. doi: 10.1016/j.fct.2014.01.009. Epub 2014 Jan 10.


Synchrotron-based imaging of chromium and γ-H2AX immunostaining in the duodenum following repeated exposure to Cr(VI) in drinking water.

Thompson CM, Seiter J, Chappell MA, Tappero RV, Proctor DM, Suh M, Wolf JC, Haws LC, Vitale R, Mittal L, Kirman CR, Hays SM, Harris MA.

Toxicol Sci. 2015 Jan;143(1):16-25. doi: 10.1093/toxsci/kfu206. Epub 2014 Oct 28.


NTP technical report on the toxicology and carcinogenesis studies of Elmiron (Cas No. 37319-17-8) in F344/N rats and B6C3F1 mice (Gavage Studies).

National Toxicology Program, Public Health Services, National Institutes of Health, US Department of Health and Human Services,.

Natl Toxicol Program Tech Rep Ser. 2004 May;(512):7-289.


Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium.

Kirman CR, Hays SM, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM.

Chem Biol Interact. 2012 Oct 25;200(1):45-64. doi: 10.1016/j.cbi.2012.08.016. Epub 2012 Sep 6. Erratum in: Chem Biol Interact. 2013 Aug 25;204(3):201-6.


Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice.

Collins BJ, Stout MD, Levine KE, Kissling GE, Melnick RL, Fennell TR, Walden R, Abdo K, Pritchard JB, Fernando RA, Burka LT, Hooth MJ.

Toxicol Sci. 2010 Dec;118(2):368-79. doi: 10.1093/toxsci/kfq263. Epub 2010 Sep 15.


A chronic oral reference dose for hexavalent chromium-induced intestinal cancer.

Thompson CM, Kirman CR, Proctor DM, Haws LC, Suh M, Hays SM, Hixon JG, Harris MA.

J Appl Toxicol. 2014 May;34(5):525-36. doi: 10.1002/jat.2907. Epub 2013 Aug 14.

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