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Items: 1 to 20 of 203

1.

Targeting protein-protein interactions and fragment-based drug discovery.

Valkov E, Sharpe T, Marsh M, Greive S, Hyvönen M.

Top Curr Chem. 2012;317:145-79. doi: 10.1007/128_2011_265. Review.

PMID:
22006238
2.

A leap into the chemical space of protein-protein interaction inhibitors.

Villoutreix BO, Labbé CM, Lagorce D, Laconde G, Sperandio O.

Curr Pharm Des. 2012;18(30):4648-67. Review.

3.

Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors.

Sable R, Jois S.

Molecules. 2015 Jun 23;20(6):11569-603. doi: 10.3390/molecules200611569. Review.

4.

Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.

Arkin MR, Tang Y, Wells JA.

Chem Biol. 2014 Sep 18;21(9):1102-14. doi: 10.1016/j.chembiol.2014.09.001. Review.

5.

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

Thiel P, Kaiser M, Ottmann C.

Angew Chem Int Ed Engl. 2012 Feb 27;51(9):2012-8. doi: 10.1002/anie.201107616. Epub 2012 Feb 3. Review.

PMID:
22308055
6.

State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors.

Sheng C, Dong G, Miao Z, Zhang W, Wang W.

Chem Soc Rev. 2015 Nov 21;44(22):8238-59. doi: 10.1039/c5cs00252d. Epub 2015 Aug 6. Review. Erratum in: Chem Soc Rev. 2015 Nov 21;44(22):8375.

PMID:
26248294
7.

Hot spot-based design of small-molecule inhibitors for protein-protein interactions.

Guo W, Wisniewski JA, Ji H.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2546-54. doi: 10.1016/j.bmcl.2014.03.095. Epub 2014 Apr 5. Erratum in: Bioorg Med Chem Lett. 2014 Aug 1;24(15):3652.

8.

AlphaSpace: Fragment-Centric Topographical Mapping To Target Protein-Protein Interaction Interfaces.

Rooklin D, Wang C, Katigbak J, Arora PS, Zhang Y.

J Chem Inf Model. 2015 Aug 24;55(8):1585-99. doi: 10.1021/acs.jcim.5b00103. Epub 2015 Aug 7.

9.

Structure-based design of small-molecule protein-protein interaction modulators: the story so far.

Falchi F, Caporuscio F, Recanatini M.

Future Med Chem. 2014 Mar;6(3):343-57. doi: 10.4155/fmc.13.204. Review.

PMID:
24575969
10.

Biophysical and computational fragment-based approaches to targeting protein-protein interactions: applications in structure-guided drug discovery.

Winter A, Higueruelo AP, Marsh M, Sigurdardottir A, Pitt WR, Blundell TL.

Q Rev Biophys. 2012 Nov;45(4):383-426. doi: 10.1017/S0033583512000108. Epub 2012 Sep 13. Review.

PMID:
22971516
11.

Inhibition of α-helix-mediated protein-protein interactions using designed molecules.

Azzarito V, Long K, Murphy NS, Wilson AJ.

Nat Chem. 2013 Mar;5(3):161-73. doi: 10.1038/nchem.1568. Review.

PMID:
23422557
12.

Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors.

Jochim AL, Arora PS.

ACS Chem Biol. 2010 Oct 15;5(10):919-23. doi: 10.1021/cb1001747.

13.

HADDOCK(2P2I): a biophysical model for predicting the binding affinity of protein-protein interaction inhibitors.

Kastritis PL, Rodrigues JP, Bonvin AM.

J Chem Inf Model. 2014 Mar 24;54(3):826-36. doi: 10.1021/ci4005332. Epub 2014 Feb 27.

14.

Small molecular weight protein-protein interaction antagonists: an insurmountable challenge?

Dömling A.

Curr Opin Chem Biol. 2008 Jun;12(3):281-91. doi: 10.1016/j.cbpa.2008.04.603. Epub 2008 May 21. Review.

PMID:
18501203
15.

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions.

Laraia L, McKenzie G, Spring DR, Venkitaraman AR, Huggins DJ.

Chem Biol. 2015 Jun 18;22(6):689-703. doi: 10.1016/j.chembiol.2015.04.019. Review.

16.

Synthesis and screening of small-molecule α-helix mimetic libraries targeting protein-protein interactions.

Moon H, Lim HS.

Curr Opin Chem Biol. 2015 Feb;24:38-47. doi: 10.1016/j.cbpa.2014.10.023. Epub 2014 Nov 15. Review.

PMID:
25461722
17.

Protein-protein interactions: network analysis and applications in drug discovery.

Bultinck J, Lievens S, Tavernier J.

Curr Pharm Des. 2012;18(30):4619-29. Review.

PMID:
22650261
18.
19.

Development of a rule-based method for the assessment of protein druggability.

Perola E, Herman L, Weiss J.

J Chem Inf Model. 2012 Apr 23;52(4):1027-38. doi: 10.1021/ci200613b. Epub 2012 Apr 9.

PMID:
22448735
20.

Ligand specificity, privileged substructures and protein druggability from fragment-based screening.

Barelier S, Krimm I.

Curr Opin Chem Biol. 2011 Aug;15(4):469-74. doi: 10.1016/j.cbpa.2011.02.020. Epub 2011 Mar 14. Review.

PMID:
21411360
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