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Results: 1 to 20 of 102

1.

Metabolism, pharmacokinetics and excretion of a novel hypoxia activated cytotoxic prodrug, TH-302, in rats.

Jung D, Jiao H, Duan JX, Matteucci M, Wang R.

Xenobiotica. 2012 Apr;42(4):372-88. doi: 10.3109/00498254.2011.622810. Epub 2011 Oct 17.

PMID:
22004352
[PubMed - indexed for MEDLINE]
2.

Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys.

Jung D, Lin L, Jiao H, Cai X, Duan JX, Matteucci M.

Cancer Chemother Pharmacol. 2012 Mar;69(3):643-54. doi: 10.1007/s00280-011-1741-6. Epub 2011 Oct 1.

PMID:
21964906
[PubMed - indexed for MEDLINE]
3.

Metabolism and excretion of TH-302 in dogs.

Jung D, Jiao H, Duan JX, Matteucci M, Wang R.

Xenobiotica. 2012 Jul;42(7):687-700. doi: 10.3109/00498254.2011.650234. Epub 2012 Feb 21.

PMID:
22352389
[PubMed - indexed for MEDLINE]
4.

Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats.

Fukano Y, Kawazu K.

Drug Metab Dispos. 2009 Aug;37(8):1622-34. doi: 10.1124/dmd.108.024885. Epub 2009 May 28.

PMID:
19477946
[PubMed - indexed for MEDLINE]
Free Article
5.

Phase 1 study of the safety, tolerability, and pharmacokinetics of TH-302, a hypoxia-activated prodrug, in patients with advanced solid malignancies.

Weiss GJ, Infante JR, Chiorean EG, Borad MJ, Bendell JC, Molina JR, Tibes R, Ramanathan RK, Lewandowski K, Jones SF, Lacouture ME, Langmuir VK, Lee H, Kroll S, Burris HA 3rd.

Clin Cancer Res. 2011 May 1;17(9):2997-3004. doi: 10.1158/1078-0432.CCR-10-3425. Epub 2011 Mar 17.

PMID:
21415214
[PubMed - indexed for MEDLINE]
Free Article
6.

Pharmacokinetics and whole-body distribution of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard and its effects on the incorporation of [methyl-3H]-thymidine in various tissues of the rat.

Stüben J, Port R, Bertram B, Bollow U, Hull WE, Schaper M, Pohl J, Wiessler M.

Cancer Chemother Pharmacol. 1996;38(4):355-65.

PMID:
8674159
[PubMed - indexed for MEDLINE]
7.

Disposition and metabolism of the new hypocholesterolemic compound S-8921 in rats and dogs.

Yamaguchi T, Nakajima Y, Mizobuchi M, Inazawa K, Kanazu T, Kadono K, Ohkawa T, Iwatani K.

Arzneimittelforschung. 1998 Oct;48(10):995-1006.

PMID:
9825117
[PubMed - indexed for MEDLINE]
8.

Pharmacokinetics, protein binding and metabolic profile of 3H-icometasone enbutate following intravenous, oral and intratracheal administrations to Sprague-Dawley rats.

Duchêne P, Giudicelli MD, Neau B, Gronfier A, Firmin Y, Villax P, Saivin S, Houin G.

Arzneimittelforschung. 1998 Apr;48(4):371-8.

PMID:
9608879
[PubMed - indexed for MEDLINE]
9.

Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats.

Egorin MJ, Lagattuta TF, Hamburger DR, Covey JM, White KD, Musser SM, Eiseman JL.

Cancer Chemother Pharmacol. 2002 Jan;49(1):7-19.

PMID:
11855755
[PubMed - indexed for MEDLINE]
10.

Pharmacokinetics of TDP223206 following intravenous and oral administration to intact rats and intravenous administration to bile duct-cannulated rats.

Chen Y, Cheng D, Marugan JJ, Manthey C, Tomczuk B, Huebert N.

Biopharm Drug Dispos. 2008 May;29(4):219-30. doi: 10.1002/bdd.601.

PMID:
18260095
[PubMed - indexed for MEDLINE]
11.

alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver.

te Koppele JM, Dogterom P, Vermeulen NP, Meijer DK, van der Gen A, Mulder GJ.

J Pharmacol Exp Ther. 1986 Dec;239(3):905-14.

PMID:
3795049
[PubMed - indexed for MEDLINE]
12.

HPLC-NMR with severe column overloading: fast-track metabolite identification in urine and bile samples from rat and dog treated with [14C]-ZD6126.

Lenz EM, D'Souza RA, Jordan AC, King CD, Smith SM, Phillips PJ, McCormick AD, Roberts DW.

J Pharm Biomed Anal. 2007 Feb 19;43(3):1065-77. Epub 2006 Oct 9.

PMID:
17030109
[PubMed - indexed for MEDLINE]
13.

Pharmacokinetics of prulifloxacin. 1st communication: absorption, distribution and excretion in rats, dogs and monkeys after a single administration.

Okuyama Y, Momota K, Morino A.

Arzneimittelforschung. 1997 Mar;47(3):276-84.

PMID:
9105546
[PubMed - indexed for MEDLINE]
14.

Pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib in rats.

Paulson SK, Zhang JY, Breau AP, Hribar JD, Liu NW, Jessen SM, Lawal YM, Cogburn JN, Gresk CJ, Markos CS, Maziasz TJ, Schoenhard GL, Burton EG.

Drug Metab Dispos. 2000 May;28(5):514-21.

PMID:
10772629
[PubMed - indexed for MEDLINE]
Free Article
15.
16.

Pharmacokinetics, distribution, metabolism and excretion of.

Yasoshima K, Kuwabara T, Fuse E, Kuramitu T, Kurata N, Nishiie H, Oishi T, Kobayashi H, Kobayashi S.

Cancer Chemother Pharmacol. 2001;47(2):106-12.

PMID:
11269735
[PubMed - indexed for MEDLINE]
18.

Orally active inhibitors of human leukocyte elastase. I. Disposition of L-683,845 in rats and rhesus monkeys.

Vincent SH, Painter SK, Krieter PA, Colletti AE, Lyszack E, Rosegay A, Dean D, Luffer-Atlas D, Miller RR, Cioffe C, Chiu SH.

Drug Metab Dispos. 1996 Dec;24(12):1369-77.

PMID:
8971144
[PubMed - indexed for MEDLINE]
19.

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