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Results: 1 to 20 of 84

1.

Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants.

Park JH, Gail MH, Weinberg CR, Carroll RJ, Chung CC, Wang Z, Chanock SJ, Fraumeni JF Jr, Chatterjee N.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18026-31. doi: 10.1073/pnas.1114759108. Epub 2011 Oct 14.

PMID:
22003128
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Estimation of effect size distribution from genome-wide association studies and implications for future discoveries.

Park JH, Wacholder S, Gail MH, Peters U, Jacobs KB, Chanock SJ, Chatterjee N.

Nat Genet. 2010 Jul;42(7):570-5. doi: 10.1038/ng.610. Epub 2010 Jun 20.

PMID:
20562874
[PubMed - indexed for MEDLINE]
3.

Genetic variants associated with complex human diseases show wide variation across multiple populations.

Adeyemo A, Rotimi C.

Public Health Genomics. 2010;13(2):72-9. doi: 10.1159/000218711. Epub 2009 May 13.

PMID:
19439916
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orrú M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR.

PLoS Genet. 2007 Jul;3(7):e115.

PMID:
17658951
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Power and SNP tagging in whole mitochondrial genome association studies.

McRae AF, Byrne EM, Zhao ZZ, Montgomery GW, Visscher PM.

Genome Res. 2008 Jun;18(6):911-7. doi: 10.1101/gr.074872.107. Epub 2008 Mar 20.

PMID:
18356315
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Design considerations for genetic linkage and association studies.

Nsengimana J, Bishop DT.

Methods Mol Biol. 2012;850:237-62. doi: 10.1007/978-1-61779-555-8_13.

PMID:
22307702
[PubMed - indexed for MEDLINE]
7.

Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease.

Ding K, Kullo IJ.

BMC Med Genet. 2011 Apr 20;12:55. doi: 10.1186/1471-2350-12-55.

PMID:
21507254
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Detailed analysis of the relative power of direct and indirect association studies and the implications for their interpretation.

Moskvina V, O'Donovan MC.

Hum Hered. 2007;64(1):63-73. Epub 2007 Apr 27.

PMID:
17483598
[PubMed - indexed for MEDLINE]
Free Article
9.

How many genetic variants remain to be discovered?

Pawitan Y, Seng KC, Magnusson PK.

PLoS One. 2009 Dec 2;4(12):e7969. doi: 10.1371/journal.pone.0007969.

PMID:
19956539
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals.

Chan Y, Holmen OL, Dauber A, Vatten L, Havulinna AS, Skorpen F, Kvaløy K, Silander K, Nguyen TT, Willer C, Boehnke M, Perola M, Palotie A, Salomaa V, Hveem K, Frayling TM, Hirschhorn JN, Weedon MN.

PLoS Genet. 2011 Dec;7(12):e1002439. doi: 10.1371/journal.pgen.1002439. Epub 2011 Dec 29.

PMID:
22242009
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Common SNPs explain a large proportion of the heritability for human height.

Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM.

Nat Genet. 2010 Jul;42(7):565-9. doi: 10.1038/ng.608. Epub 2010 Jun 20.

PMID:
20562875
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.

Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, Nilsen GB, Ruau D, Lincoln SE, Bustamante CD, Butte AJ.

PLoS Genet. 2012;8(4):e1002621. doi: 10.1371/journal.pgen.1002621. Epub 2012 Apr 12.

PMID:
22511877
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Genome-wide association with diabetes-related traits in the Framingham Heart Study.

Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, Dupuis J.

BMC Med Genet. 2007 Sep 19;8 Suppl 1:S16.

PMID:
17903298
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Power for genetic association studies with random allele frequencies and genotype distributions.

Ambrosius WT, Lange EM, Langefeld CD.

Am J Hum Genet. 2004 Apr;74(4):683-93. Epub 2004 Mar 12.

PMID:
15024689
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Genetic association studies of complex traits: design and analysis issues.

Newton-Cheh C, Hirschhorn JN.

Mutat Res. 2005 Jun 3;573(1-2):54-69. Review.

PMID:
15829237
[PubMed - indexed for MEDLINE]
16.

Novel method to estimate the phenotypic variation explained by genome-wide association studies reveals large fraction of the missing heritability.

Kutalik Z, Whittaker J, Waterworth D; GIANT consortium, Beckmann JS, Bergmann S.

Genet Epidemiol. 2011 Jul;35(5):341-9. doi: 10.1002/gepi.20582. Epub 2011 Apr 4.

PMID:
21465548
[PubMed - indexed for MEDLINE]
17.
18.

Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies.

So HC, Yip BH, Sham PC.

PLoS One. 2010 Nov 17;5(11):e13898. doi: 10.1371/journal.pone.0013898.

PMID:
21103334
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.

Lee SH, Harold D, Nyholt DR; ANZGene Consortium; International Endogene Consortium; Genetic and Environmental Risk for Alzheimer's disease Consortium, Goddard ME, Zondervan KT, Williams J, Montgomery GW, Wray NR, Visscher PM.

Hum Mol Genet. 2013 Feb 15;22(4):832-41. doi: 10.1093/hmg/dds491. Epub 2012 Nov 28.

PMID:
23193196
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Molecular genetic studies of complex phenotypes.

Marian AJ.

Transl Res. 2012 Feb;159(2):64-79. doi: 10.1016/j.trsl.2011.08.001. Epub 2011 Aug 31. Review.

PMID:
22243791
[PubMed - indexed for MEDLINE]
Free PMC Article

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