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Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance.

Loh K, Fukushima A, Zhang X, Galic S, Briggs D, Enriori PJ, Simonds S, Wiede F, Reichenbach A, Hauser C, Sims NA, Bence KK, Zhang S, Zhang ZY, Kahn BB, Neel BG, Andrews ZB, Cowley MA, Tiganis T.

Cell Metab. 2011 Nov 2;14(5):684-99. doi: 10.1016/j.cmet.2011.09.011. Epub 2011 Oct 13. Erratum in: Cell Metab. 2012 Jun 6;15(6):925-6.


Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase.

Bettaieb A, Liu S, Xi Y, Nagata N, Matsuo K, Matsuo I, Chahed S, Bakke J, Keilhack H, Tiganis T, Haj FG.

J Biol Chem. 2011 Mar 18;286(11):9225-35. doi: 10.1074/jbc.M110.186148. Epub 2011 Jan 7.


Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.

Zhang ZY, Dodd GT, Tiganis T.

Trends Pharmacol Sci. 2015 Oct;36(10):661-74. doi: 10.1016/ Review.


Protein tyrosine phosphatase-1B contributes to LPS-induced leptin resistance in male rats.

Borges Bde C, Rorato RC, Uchoa ET, Marangon PB, Elias CF, Antunes-Rodrigues J, Elias LL.

Am J Physiol Endocrinol Metab. 2015 Jan 1;308(1):E40-50. doi: 10.1152/ajpendo.00094.2014. Epub 2014 Oct 28.


The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling.

Pandey NR, Zhou X, Qin Z, Zaman T, Gomez-Smith M, Keyhanian K, Anisman H, Brunel JM, Stewart AF, Chen HH.

J Neurosci. 2013 Jul 31;33(31):12647-55. doi: 10.1523/JNEUROSCI.0746-13.2013.


T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice.

Loh K, Merry TL, Galic S, Wu BJ, Watt MJ, Zhang S, Zhang ZY, Neel BG, Tiganis T.

Diabetologia. 2012 Feb;55(2):468-78. doi: 10.1007/s00125-011-2386-z. Epub 2011 Nov 29.


Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice.

Tsou RC, Zimmer DJ, De Jonghe BC, Bence KK.

Endocrinology. 2012 Sep;153(9):4227-37. doi: 10.1210/en.2012-1548. Epub 2012 Jul 16.


HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms.

White CL, Whittington A, Barnes MJ, Wang Z, Bray GA, Morrison CD.

Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E291-9. doi: 10.1152/ajpendo.90513.2008. Epub 2008 Nov 18.


Acute exercise suppresses hypothalamic PTP1B protein level and improves insulin and leptin signaling in obese rats.

Chiarreotto-Ropelle EC, Pauli LS, Katashima CK, Pimentel GD, Picardi PK, Silva VR, de Souza CT, Prada PO, Cintra DE, Carvalheira JB, Ropelle ER, Pauli JR.

Am J Physiol Endocrinol Metab. 2013 Sep 1;305(5):E649-59. doi: 10.1152/ajpendo.00272.2013. Epub 2013 Jul 23.


Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.

De Jonghe BC, Hayes MR, Zimmer DJ, Kanoski SE, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51. doi: 10.1152/ajpendo.00009.2012. Epub 2012 Jul 3.


Chronic sleep fragmentation during the sleep period induces hypothalamic endoplasmic reticulum stress and PTP1b-mediated leptin resistance in male mice.

Hakim F, Wang Y, Carreras A, Hirotsu C, Zhang J, Peris E, Gozal D.

Sleep. 2015 Jan 1;38(1):31-40. doi: 10.5665/sleep.4320.


Neuronal androgen receptor regulates insulin sensitivity via suppression of hypothalamic NF-κB-mediated PTP1B expression.

Yu IC, Lin HY, Liu NC, Sparks JD, Yeh S, Fang LY, Chen L, Chang C.

Diabetes. 2013 Feb;62(2):411-23. doi: 10.2337/db12-0135. Epub 2012 Nov 8.


PTP1B regulates leptin signal transduction in vivo.

Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG.

Dev Cell. 2002 Apr;2(4):489-95.


Protein tyrosine phosphatase 1B negatively regulates leptin signaling in a hypothalamic cell line.

Kaszubska W, Falls HD, Schaefer VG, Haasch D, Frost L, Hessler P, Kroeger PE, White DW, Jirousek MR, Trevillyan JM.

Mol Cell Endocrinol. 2002 Sep 30;195(1-2):109-18.


Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis.

Panzhinskiy E, Ren J, Nair S.

PLoS One. 2013 Oct 18;8(10):e77228. doi: 10.1371/journal.pone.0077228. eCollection 2013.


Leptin and insulin act on POMC neurons to promote the browning of white fat.

Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T.

Cell. 2015 Jan 15;160(1-2):88-104. doi: 10.1016/j.cell.2014.12.022.


Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.

De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK.

Am J Physiol Endocrinol Metab. 2011 Jun;300(6):E1002-11. doi: 10.1152/ajpendo.00639.2010. Epub 2011 Mar 15.


Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.

He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS.

Mol Cell Biol. 2012 May;32(10):1867-78. doi: 10.1128/MCB.06712-11. Epub 2012 Mar 19.


Pharmacological effects of JTT-551, a novel protein tyrosine phosphatase 1B inhibitor, in diet-induced obesity mice.

Ito M, Fukuda S, Sakata S, Morinaga H, Ohta T.

J Diabetes Res. 2014;2014:680348. doi: 10.1155/2014/680348. Epub 2014 May 29.


Over-expression of leptin receptors in hypothalamic POMC neurons increases susceptibility to diet-induced obesity.

Gamber KM, Huo L, Ha S, Hairston JE, Greeley S, Bjørbæk C.

PLoS One. 2012;7(1):e30485. doi: 10.1371/journal.pone.0030485. Epub 2012 Jan 20.

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