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Results: 1 to 20 of 94

1.

Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury.

Ladage D, Tilemann L, Ishikawa K, Correll RN, Kawase Y, Houser SR, Molkentin JD, Hajjar RJ.

Circ Res. 2011 Dec 9;109(12):1396-400. doi: 10.1161/CIRCRESAHA.111.255687. Epub 2011 Oct 13.

PMID:
21998327
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach.

Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD.

Circ Res. 2009 Jul 17;105(2):194-200. doi: 10.1161/CIRCRESAHA.109.195313. Epub 2009 Jun 25.

PMID:
19556521
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Pharmacological- and gene therapy-based inhibition of protein kinase Calpha/beta enhances cardiac contractility and attenuates heart failure.

Hambleton M, Hahn H, Pleger ST, Kuhn MC, Klevitsky R, Carr AN, Kimball TF, Hewett TE, Dorn GW 2nd, Koch WJ, Molkentin JD.

Circulation. 2006 Aug 8;114(6):574-82. Epub 2006 Jul 31.

PMID:
16880328
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure.

Hambleton M, York A, Sargent MA, Kaiser RA, Lorenz JN, Robbins J, Molkentin JD.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3768-71. Epub 2007 Oct 5.

PMID:
17921332
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

PKC-ing is believing: targeting protein kinase C in heart failure.

Belmonte SL, Blaxall BC.

Circ Res. 2011 Dec 9;109(12):1320-2. doi: 10.1161/CIRCRESAHA.111.259358. No abstract available.

PMID:
22158646
[PubMed - indexed for MEDLINE]
Free Article
6.

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy.

Connelly KA, Kelly DJ, Zhang Y, Prior DL, Advani A, Cox AJ, Thai K, Krum H, Gilbert RE.

Circ Heart Fail. 2009 Mar;2(2):129-37. doi: 10.1161/CIRCHEARTFAILURE.108.765750. Epub 2009 Feb 10.

PMID:
19808328
[PubMed - indexed for MEDLINE]
Free Article
7.

Inhibition of protein kinase C reduces left ventricular fibrosis and dysfunction following myocardial infarction.

Boyle AJ, Kelly DJ, Zhang Y, Cox AJ, Gow RM, Way K, Itescu S, Krum H, Gilbert RE.

J Mol Cell Cardiol. 2005 Aug;39(2):213-21.

PMID:
15878171
[PubMed - indexed for MEDLINE]
8.

A novel potential therapy for diabetic nephropathy and vascular complications: protein kinase C beta inhibition.

Tuttle KR, Anderson PW.

Am J Kidney Dis. 2003 Sep;42(3):456-65. Review.

PMID:
12955673
[PubMed - indexed for MEDLINE]
9.

Passive ventricular constraint to improve left ventricular function and mechanics in an ovine model of heart failure secondary to acute myocardial infarction.

Pilla JJ, Blom AS, Brockman DJ, Ferrari VA, Yuan Q, Acker MA.

J Thorac Cardiovasc Surg. 2003 Nov;126(5):1467-76.

PMID:
14666021
[PubMed - indexed for MEDLINE]
10.

Selective inhibition of p38alpha MAPK improves cardiac function and reduces myocardial apoptosis in rat model of myocardial injury.

Li Z, Ma JY, Kerr I, Chakravarty S, Dugar S, Schreiner G, Protter AA.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1972-7. Epub 2006 Jun 2.

PMID:
16751295
[PubMed - indexed for MEDLINE]
Free Article
11.

Improvement of heart function in postinfarct heart failure swine models after hepatocyte growth factor gene transfer: comparison of low-, medium- and high-dose groups.

Yang ZJ, Chen B, Sheng Z, Zhang DG, Jia EZ, Wang W, Ma DC, Zhu TB, Wang LS, Li CJ, Wang H, Cao KJ, Ma WZ.

Mol Biol Rep. 2010 Apr;37(4):2075-81. doi: 10.1007/s11033-009-9665-5. Epub 2009 Aug 13.

PMID:
19680789
[PubMed - indexed for MEDLINE]
12.

Protein kinase C-beta inhibition attenuates the progression of nephropathy in non-diabetic kidney disease.

Kelly DJ, Edgley AJ, Zhang Y, Thai K, Tan SM, Cox AJ, Advani A, Connelly KA, Whiteside CI, Gilbert RE.

Nephrol Dial Transplant. 2009 Jun;24(6):1782-90. doi: 10.1093/ndt/gfn729. Epub 2009 Jan 20.

PMID:
19155535
[PubMed - indexed for MEDLINE]
Free Article
13.

Changes in Hsp60 level of the failing heart following acute myocardial infarction and the effect of long-term treatment with trandolapril.

Toga W, Tanonaka K, Takeo S.

Biol Pharm Bull. 2007 Jan;30(1):105-10.

PMID:
17202668
[PubMed - indexed for MEDLINE]
Free Article
14.

Inhibition of p38 mitogen-activated protein kinase protects the heart against cardiac remodeling in mice with heart failure resulting from myocardial infarction.

Liu YH, Wang D, Rhaleb NE, Yang XP, Xu J, Sankey SS, Rudolph AE, Carretero OA.

J Card Fail. 2005 Feb;11(1):74-81.

PMID:
15704068
[PubMed - indexed for MEDLINE]
15.

Growth hormone improves cardiac performance in experimental heart failure.

Yang R, Bunting S, Gillett N, Clark R, Jin H.

Circulation. 1995 Jul 15;92(2):262-7.

PMID:
7600659
[PubMed - indexed for MEDLINE]
Free Article
16.

Ruboxistaurin mesilate hydrate for diabetic retinopathy.

Schwartz SG, Flynn HW Jr, Aiello LP.

Drugs Today (Barc). 2009 Apr;45(4):269-74. doi: 10.1358/dot.2009.45.4.1354195. Review.

PMID:
19499092
[PubMed - indexed for MEDLINE]
17.

Ruboxistaurin, a PKCbeta inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.

Nakamura S, Chikaraishi Y, Tsuruma K, Shimazawa M, Hara H.

Exp Eye Res. 2010 Jan;90(1):137-45. doi: 10.1016/j.exer.2009.09.022. Epub 2009 Oct 13.

PMID:
19825373
[PubMed - indexed for MEDLINE]
18.

Atorvastatin inhibits myocardial cell apoptosis in a rat model with post-myocardial infarction heart failure by downregulating ER stress response.

Song XJ, Yang CY, Liu B, Wei Q, Korkor MT, Liu JY, Yang P.

Int J Med Sci. 2011;8(7):564-72. Epub 2011 Sep 22.

PMID:
21960749
[PubMed - indexed for MEDLINE]
Free PMC Article
19.
20.

Vitamin C restores the contractile response to dobutamine and improves myocardial efficiency in patients with heart failure after anterior myocardial infarction.

Shinke T, Shite J, Takaoka H, Hata K, Inoue N, Yoshikawa R, Matsumoto H, Masai H, Watanabe S, Ozawa T, Otake H, Matsumoto D, Hirata K, Yokoyama M.

Am Heart J. 2007 Oct;154(4):645.e1-8.

PMID:
17892985
[PubMed - indexed for MEDLINE]

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