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Cyclic AMP/PKA-dependent paradoxical activation of Raf/MEK/ERK signaling in polycystin-2 defective mice treated with sorafenib.

Spirli C, Morell CM, Locatelli L, Okolicsanyi S, Ferrero C, Kim AK, Fabris L, Fiorotto R, Strazzabosco M.

Hepatology. 2012 Dec;56(6):2363-74. doi: 10.1002/hep.25872. Epub 2012 Aug 27.


ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice.

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M.

Gastroenterology. 2010 Jan;138(1):360-371.e7. doi: 10.1053/j.gastro.2009.09.005. Epub 2009 Sep 18.


Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice.

Spirli C, Okolicsanyi S, Fiorotto R, Fabris L, Cadamuro M, Lecchi S, Tian X, Somlo S, Strazzabosco M.

Hepatology. 2010 May;51(5):1778-88. doi: 10.1002/hep.23511.


cAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca2+ entry (SOCE) in islet cells.

Tian G, Tepikin AV, Tengholm A, Gylfe E.

J Biol Chem. 2012 Mar 23;287(13):9862-72. doi: 10.1074/jbc.M111.292854. Epub 2012 Feb 1.


Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage.

Spirli C, Villani A, Mariotti V, Fabris L, Fiorotto R, Strazzabosco M.

Hepatology. 2015 Dec;62(6):1828-39. doi: 10.1002/hep.28138. Epub 2015 Oct 10.


The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD).

Banales JM, Masyuk TV, Gradilone SA, Masyuk AI, Medina JF, LaRusso NF.

Hepatology. 2009 Jan;49(1):160-74. doi: 10.1002/hep.22636.


The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function.

Cantero Mdel R, Velázquez IF, Streets AJ, Ong AC, Cantiello HF.

J Biol Chem. 2015 Sep 25;290(39):23888-96. doi: 10.1074/jbc.M115.661082. Epub 2015 Aug 12.


Adenylate cyclase/cAMP/protein kinase A signaling pathway inhibits endothelin type A receptor-operated Ca²⁺ entry mediated via transient receptor potential canonical 6 channels.

Horinouchi T, Higa T, Aoyagi H, Nishiya T, Terada K, Miwa S.

J Pharmacol Exp Ther. 2012 Jan;340(1):143-51. doi: 10.1124/jpet.111.187500. Epub 2011 Oct 14.


Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1.

Woodward OM, Li Y, Yu S, Greenwell P, Wodarczyk C, Boletta A, Guggino WB, Qian F.

PLoS One. 2010 Aug 23;5(8):e12305. doi: 10.1371/journal.pone.0012305.


Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms.

Francis HL, Demorrow S, Franchitto A, Venter JK, Mancinelli RA, White MA, Meng F, Ueno Y, Carpino G, Renzi A, Baker KK, Shine HE, Francis TC, Gaudio E, Alpini GD, Onori P.

Lab Invest. 2012 Feb;92(2):282-94. doi: 10.1038/labinvest.2011.158. Epub 2011 Nov 7.


H3 histamine receptor agonist inhibits biliary growth of BDL rats by downregulation of the cAMP-dependent PKA/ERK1/2/ELK-1 pathway.

Francis H, Franchitto A, Ueno Y, Glaser S, DeMorrow S, Venter J, Gaudio E, Alvaro D, Fava G, Marzioni M, Vaculin B, Alpini G.

Lab Invest. 2007 May;87(5):473-87. Epub 2007 Mar 5.


Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation.

Rodríguez-Moyano M, Díaz I, Dionisio N, Zhang X, Avila-Medina J, Calderón-Sánchez E, Trebak M, Rosado JA, Ordóñez A, Smani T.

Cardiovasc Res. 2013 Nov 1;100(2):297-306. doi: 10.1093/cvr/cvt196. Epub 2013 Aug 9.


Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F930-45. Epub 2006 Nov 7.


Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.

Streets AJ, Wessely O, Peters DJ, Ong AC.

Hum Mol Genet. 2013 May 15;22(10):1924-39. doi: 10.1093/hmg/ddt031. Epub 2013 Feb 5.


Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.

Soltoff SP, Lannon WA.

PLoS One. 2013 Aug 29;8(8):e72881. doi: 10.1371/journal.pone.0072881. eCollection 2013.


Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry.

Pozo-Guisado E, Campbell DG, Deak M, Alvarez-Barrientos A, Morrice NA, Alvarez IS, Alessi DR, Martín-Romero FJ.

J Cell Sci. 2010 Sep 15;123(Pt 18):3084-93. doi: 10.1242/jcs.067215. Epub 2010 Aug 24.


Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.

Yan X, Xing J, Lorin-Nebel C, Estevez AY, Nehrke K, Lamitina T, Strange K.

J Gen Physiol. 2006 Oct;128(4):443-59. Epub 2006 Sep 11.


Sex differences in SR Ca(2+) release in murine ventricular myocytes are regulated by the cAMP/PKA pathway.

Parks RJ, Ray G, Bienvenu LA, Rose RA, Howlett SE.

J Mol Cell Cardiol. 2014 Oct;75:162-73. doi: 10.1016/j.yjmcc.2014.07.006. Epub 2014 Jul 24.

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