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Items: 1 to 20 of 251


Cigarette smoke causes lung vascular barrier dysfunction via oxidative stress-mediated inhibition of RhoA and focal adhesion kinase.

Lu Q, Sakhatskyy P, Grinnell K, Newton J, Ortiz M, Wang Y, Sanchez-Esteban J, Harrington EO, Rounds S.

Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L847-57. doi: 10.1152/ajplung.00178.2011. Epub 2011 Oct 7.


Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides.

Schweitzer KS, Hatoum H, Brown MB, Gupta M, Justice MJ, Beteck B, Van Demark M, Gu Y, Presson RG Jr, Hubbard WC, Petrache I.

Am J Physiol Lung Cell Mol Physiol. 2011 Dec;301(6):L836-46. doi: 10.1152/ajplung.00385.2010. Epub 2011 Aug 26.


Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities.

Schmidt TT, Tauseef M, Yue L, Bonini MG, Gothert J, Shen TL, Guan JL, Predescu S, Sadikot R, Mehta D.

Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L291-300. doi: 10.1152/ajplung.00094.2013. Epub 2013 Jun 14.


Cigarette smoke-induced lung endothelial apoptosis and emphysema are associated with impairment of FAK and eIF2α.

Sakhatskyy P, Gabino Miranda GA, Newton J, Lee CG, Choudhary G, Vang A, Rounds S, Lu Q.

Microvasc Res. 2014 Jul;94:80-9. doi: 10.1016/j.mvr.2014.05.003. Epub 2014 May 20.


Sustained adenosine exposure causes lung endothelial barrier dysfunction via nucleoside transporter-mediated signaling.

Lu Q, Newton J, Hsiao V, Shamirian P, Blackburn MR, Pedroza M.

Am J Respir Cell Mol Biol. 2012 Nov;47(5):604-13. doi: 10.1165/rcmb.2012-0012OC. Epub 2012 Jun 28.


PKCdelta regulates endothelial basal barrier function through modulation of RhoA GTPase activity.

Harrington EO, Shannon CJ, Morin N, Rowlett H, Murphy C, Lu Q.

Exp Cell Res. 2005 Aug 15;308(2):407-21.


Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability.

Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, Mehta D.

J Biol Chem. 2006 Jan 27;281(4):2296-305. Epub 2005 Nov 24.


SH2 domain-containing protein tyrosine phosphatase 2 and focal adhesion kinase protein interactions regulate pulmonary endothelium barrier function.

Chichger H, Braza J, Duong H, Harrington EO.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):695-707. doi: 10.1165/rcmb.2013-0489OC.


Oxidative stress contributes to lung injury and barrier dysfunction via microtubule destabilization.

Kratzer E, Tian Y, Sarich N, Wu T, Meliton A, Leff A, Birukova AA.

Am J Respir Cell Mol Biol. 2012 Nov;47(5):688-97. doi: 10.1165/rcmb.2012-0161OC. Epub 2012 Jul 27.


Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins.

Usatyuk PV, Parinandi NL, Natarajan V.

J Biol Chem. 2006 Nov 17;281(46):35554-66. Epub 2006 Sep 17.


Regulation of reactive oxygen species-induced endothelial cell-cell and cell-matrix contacts by focal adhesion kinase and adherens junction proteins.

Usatyuk PV, Natarajan V.

Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L999-1010. Epub 2005 Jul 22.


Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cells.

Shikata Y, Rios A, Kawkitinarong K, DePaola N, Garcia JG, Birukov KG.

Exp Cell Res. 2005 Mar 10;304(1):40-9. Epub 2004 Nov 26.


Requirements for proximal tubule epithelial cell detachment in response to ischemia: role of oxidative stress.

Sáenz-Morales D, Escribese MM, Stamatakis K, García-Martos M, Alegre L, Conde E, Pérez-Sala D, Mampaso F, García-Bermejo ML.

Exp Cell Res. 2006 Nov 15;312(19):3711-27. Epub 2006 Sep 12.


Reversal of second-hand cigarette smoke-induced impairment of corneal wound healing by thymosin beta4 combined with anti-inflammatory agents.

Yuan H, Ma C, Moinet L, Sato N, Martins-Green M.

Invest Ophthalmol Vis Sci. 2010 May;51(5):2424-35. doi: 10.1167/iovs.09-3692. Epub 2009 Dec 17.


Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6.

Borgas D, Chambers E, Newton J, Ko J, Rivera S, Rounds S, Lu Q.

Am J Respir Cell Mol Biol. 2015 Oct 9. [Epub ahead of print]


Thrombospondin induces RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly.

Orr AW, Pallero MA, Xiong WC, Murphy-Ullrich JE.

J Biol Chem. 2004 Nov 19;279(47):48983-92. Epub 2004 Sep 13.


Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6.

Birukova AA, Tian Y, Meliton A, Leff A, Wu T, Birukov KG.

Am J Physiol Lung Cell Mol Physiol. 2012 May 1;302(9):L965-75. doi: 10.1152/ajplung.00292.2011. Epub 2012 Feb 17.


Transforming growth factor-beta1-induced endothelial barrier dysfunction involves Smad2-dependent p38 activation and subsequent RhoA activation.

Lu Q, Harrington EO, Jackson H, Morin N, Shannon C, Rounds S.

J Appl Physiol (1985). 2006 Aug;101(2):375-84. Epub 2006 Apr 27.


Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury.

Guan Y, Li FF, Hong L, Yan XF, Tan GL, He JS, Dong XW, Bao MJ, Xie QM.

Fundam Clin Pharmacol. 2012 Aug;26(4):473-83. doi: 10.1111/j.1472-8206.2011.00956.x. Epub 2011 Jun 1.


Constitutive activation of Rho proteins by CNF-1 influences tight junction structure and epithelial barrier function.

Hopkins AM, Walsh SV, Verkade P, Boquet P, Nusrat A.

J Cell Sci. 2003 Feb 15;116(Pt 4):725-42.

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