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Items: 1 to 20 of 104


Complement factor H binds malondialdehyde epitopes and protects from oxidative stress.

Weismann D, Hartvigsen K, Lauer N, Bennett KL, Scholl HP, Charbel Issa P, Cano M, Brandstätter H, Tsimikas S, Skerka C, Superti-Furga G, Handa JT, Zipfel PF, Witztum JL, Binder CJ.

Nature. 2011 Oct 5;478(7367):76-81. doi: 10.1038/nature10449.


Recognition of malondialdehyde-modified proteins by the C terminus of complement factor H is mediated via the polyanion binding site and impaired by mutations found in atypical hemolytic uremic syndrome.

Hyvärinen S, Uchida K, Varjosalo M, Jokela R, Jokiranta TS.

J Biol Chem. 2014 Feb 14;289(7):4295-306. doi: 10.1074/jbc.M113.527416. Epub 2013 Dec 16.


Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

Shaw PX, Zhang L, Zhang M, Du H, Zhao L, Lee C, Grob S, Lim SL, Hughes G, Lee J, Bedell M, Nelson MH, Lu F, Krupa M, Luo J, Ouyang H, Tu Z, Su Z, Zhu J, Wei X, Feng Z, Duan Y, Yang Z, Ferreyra H, Bartsch DU, Kozak I, Zhang L, Lin F, Sun H, Feng H, Zhang K.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13757-62. doi: 10.1073/pnas.1121309109. Epub 2012 Aug 8.


Complement factor H and age-related macular degeneration: the role of glycosaminoglycan recognition in disease pathology.

Clark SJ, Bishop PN, Day AJ.

Biochem Soc Trans. 2010 Oct;38(5):1342-8. doi: 10.1042/BST0381342. Review.


Identification of factor H-like protein 1 as the predominant complement regulator in Bruch's membrane: implications for age-related macular degeneration.

Clark SJ, Schmidt CQ, White AM, Hakobyan S, Morgan BP, Bishop PN.

J Immunol. 2014 Nov 15;193(10):4962-70. doi: 10.4049/jimmunol.1401613. Epub 2014 Oct 10.


The effect of photo-oxidative stress and inflammatory cytokine on complement factor H expression in retinal pigment epithelial cells.

Lau LI, Chiou SH, Liu CJ, Yen MY, Wei YH.

Invest Ophthalmol Vis Sci. 2011 Aug 29;52(9):6832-41. doi: 10.1167/iovs.11-7815.


Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

Clark SJ, Perveen R, Hakobyan S, Morgan BP, Sim RB, Bishop PN, Day AJ.

J Biol Chem. 2010 Sep 24;285(39):30192-202. doi: 10.1074/jbc.M110.103986. Epub 2010 Jul 26.


A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice.

Aredo B, Li T, Chen X, Zhang K, Wang CX, Gou D, Zhao B, He Y, Ufret-Vincenty RL.

Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3427-40. doi: 10.1167/iovs.14-16089.


Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration.

Kelly U, Yu L, Kumar P, Ding JD, Jiang H, Hageman GS, Arshavsky VY, Frank MM, Hauser MA, Rickman CB.

J Immunol. 2010 Nov 1;185(9):5486-94. doi: 10.4049/jimmunol.0903596. Epub 2010 Sep 27.


Interleukin 27 induces the expression of complement factor H (CFH) in the retina.

Amadi-Obi A, Yu CR, Dambuza I, Kim SH, Marrero B, Egwuagu CE.

PLoS One. 2012;7(9):e45801. doi: 10.1371/journal.pone.0045801. Epub 2012 Sep 20.


Age-related macular degeneration in the aspect of chronic low-grade inflammation (pathophysiological parainflammation).

Nita M, Grzybowski A, Ascaso FJ, Huerva V.

Mediators Inflamm. 2014;2014:930671. doi: 10.1155/2014/930671. Epub 2014 Aug 19.


Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.

Radu RA, Hu J, Jiang Z, Bok D.

J Biol Chem. 2014 Mar 28;289(13):9113-20. doi: 10.1074/jbc.M114.548669. Epub 2014 Feb 18.


Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation.

Khandhadia S, Hakobyan S, Heng LZ, Gibson J, Adams DH, Alexander GJ, Gibson JM, Martin KR, Menon G, Nash K, Sivaprasad S, Ennis S, Cree AJ, Morgan BP, Lotery AJ.

Ophthalmology. 2013 Aug;120(8):1612-8. doi: 10.1016/j.ophtha.2013.01.004. Epub 2013 Apr 4.


An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD).

Fritsche LG, Lauer N, Hartmann A, Stippa S, Keilhauer CN, Oppermann M, Pandey MK, Köhl J, Zipfel PF, Weber BH, Skerka C.

Hum Mol Genet. 2010 Dec 1;19(23):4694-704. doi: 10.1093/hmg/ddq399. Epub 2010 Sep 15.


Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice.

Rowan S, Weikel K, Chang ML, Nagel BA, Thinschmidt JS, Carey A, Grant MB, Fliesler SJ, Smith D, Taylor A.

Invest Ophthalmol Vis Sci. 2014 Jan 23;55(1):492-501. doi: 10.1167/iovs.13-12413.


Age-related macular degeneration and the role of the complement system.

McHarg S, Clark SJ, Day AJ, Bishop PN.

Mol Immunol. 2015 Sep;67(1):43-50. doi: 10.1016/j.molimm.2015.02.032. Epub 2015 Mar 21. Review.


Age-related macular degeneration and the complement system.

Khandhadia S, Cipriani V, Yates JR, Lotery AJ.

Immunobiology. 2012 Feb;217(2):127-46. doi: 10.1016/j.imbio.2011.07.019. Epub 2011 Jul 23. Review.


Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

Clark SJ, Ridge LA, Herbert AP, Hakobyan S, Mulloy B, Lennon R, Würzner R, Morgan BP, Uhrín D, Bishop PN, Day AJ.

J Immunol. 2013 Mar 1;190(5):2049-57. doi: 10.4049/jimmunol.1201751. Epub 2013 Jan 30.


Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration.

Pujol-Lereis LM, Schäfer N, Kuhn LB, Rohrer B, Pauly D.

Adv Exp Med Biol. 2016;854:87-93. doi: 10.1007/978-3-319-17121-0_13. Review.

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