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Results: 1 to 20 of 102

1.

A mouse model of accelerated liver aging caused by a defect in DNA repair.

Gregg SQ, Gutiérrez V, Robinson AR, Woodell T, Nakao A, Ross MA, Michalopoulos GK, Rigatti L, Rothermel CE, Kamileri I, Garinis GA, Stolz DB, Niedernhofer LJ.

Hepatology. 2012 Feb;55(2):609-21. doi: 10.1002/hep.24713.

PMID:
21953681
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging.

Schermer B, Bartels V, Frommolt P, Habermann B, Braun F, Schultze JL, Roodbergen M, Hoeijmakers JH, Schumacher B, Nürnberg P, Dollé ME, Benzing T, Müller RU, Kurschat CE.

BMC Genomics. 2013 Aug 16;14:559. doi: 10.1186/1471-2164-14-559.

PMID:
23947592
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Premature aging-related peripheral neuropathy in a mouse model of progeria.

Goss JR, Stolz DB, Robinson AR, Zhang M, Arbujas N, Robbins PD, Glorioso JC, Niedernhofer LJ.

Mech Ageing Dev. 2011 Aug;132(8-9):437-42. doi: 10.1016/j.mad.2011.04.010. Epub 2011 May 11.

PMID:
21596054
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Accelerated aging of intervertebral discs in a mouse model of progeria.

Vo N, Seo HY, Robinson A, Sowa G, Bentley D, Taylor L, Studer R, Usas A, Huard J, Alber S, Watkins SC, Lee J, Coehlo P, Wang D, Loppini M, Robbins PD, Niedernhofer LJ, Kang J.

J Orthop Res. 2010 Dec;28(12):1600-7. doi: 10.1002/jor.21153.

PMID:
20973062
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice.

Roh DS, Du Y, Gabriele ML, Robinson AR, Niedernhofer LJ, Funderburgh JL.

Aging Cell. 2013 Dec;12(6):1122-31. doi: 10.1111/acel.12143. Epub 2013 Sep 1.

PMID:
23927039
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress.

Nidadavolu LS, Niedernhofer LJ, Khan SA.

Aging (Albany NY). 2013 Jun;5(6):460-73.

PMID:
23852002
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis.

Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH.

Nature. 2006 Dec 21;444(7122):1038-43.

PMID:
17183314
[PubMed - indexed for MEDLINE]
8.

DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism.

Chen Q, Liu K, Robinson AR, Clauson CL, Blair HC, Robbins PD, Niedernhofer LJ, Ouyang H.

J Bone Miner Res. 2013 May;28(5):1214-28. doi: 10.1002/jbmr.1851.

PMID:
23281008
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice.

Prasher JM, Lalai AS, Heijmans-Antonissen C, Ploemacher RE, Hoeijmakers JH, Touw IP, Niedernhofer LJ.

EMBO J. 2005 Feb 23;24(4):861-71. Epub 2005 Feb 3.

PMID:
15692571
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Tilstra JS, Robinson AR, Wang J, Gregg SQ, Clauson CL, Reay DP, Nasto LA, St Croix CM, Usas A, Vo N, Huard J, Clemens PR, Stolz DB, Guttridge DC, Watkins SC, Garinis GA, Wang Y, Niedernhofer LJ, Robbins PD.

J Clin Invest. 2012 Jul 2;122(7):2601-12. doi: 10.1172/JCI45785. Epub 2012 Jun 18.

PMID:
22706308
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Characterization of premature liver polyploidy in DNA repair (Ercc1)-deficient mice.

Chipchase MD, O'Neill M, Melton DW.

Hepatology. 2003 Oct;38(4):958-66.

PMID:
14512883
[PubMed - indexed for MEDLINE]
12.

Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs.

Nasto LA, Wang D, Robinson AR, Clauson CL, Ngo K, Dong Q, Roughley P, Epperly M, Huq SM, Pola E, Sowa G, Robbins PD, Kang J, Niedernhofer LJ, Vo NV.

Mech Ageing Dev. 2013 Jan-Feb;134(1-2):35-42. doi: 10.1016/j.mad.2012.11.002. Epub 2012 Dec 19.

PMID:
23262094
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria.

Kamileri I, Karakasilioti I, Sideri A, Kosteas T, Tatarakis A, Talianidis I, Garinis GA.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000. doi: 10.1073/pnas.1114941109. Epub 2012 Feb 8.

PMID:
22323595
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Nucleotide excision DNA repair is associated with age-related vascular dysfunction.

Durik M, Kavousi M, van der Pluijm I, Isaacs A, Cheng C, Verdonk K, Loot AE, Oeseburg H, Bhaggoe UM, Leijten F, van Veghel R, de Vries R, Rudez G, Brandt R, Ridwan YR, van Deel ED, de Boer M, Tempel D, Fleming I, Mitchell GF, Verwoert GC, Tarasov KV, Uitterlinden AG, Hofman A, Duckers HJ, van Duijn CM, Oostra BA, Witteman JC, Duncker DJ, Danser AH, Hoeijmakers JH, Roks AJ.

Circulation. 2012 Jul 24;126(4):468-78. doi: 10.1161/CIRCULATIONAHA.112.104380. Epub 2012 Jun 15.

PMID:
22705887
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Accelerated loss of hearing and vision in the DNA-repair deficient Ercc1(δ/-) mouse.

Spoor M, Nagtegaal AP, Ridwan Y, Borgesius NZ, van Alphen B, van der Pluijm I, Hoeijmakers JH, Frens MA, Borst JG.

Mech Ageing Dev. 2012 Feb-Mar;133(2-3):59-67. doi: 10.1016/j.mad.2011.12.003. Epub 2012 Jan 12.

PMID:
22257940
[PubMed - indexed for MEDLINE]
16.

ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging.

Nasto LA, Seo HY, Robinson AR, Tilstra JS, Clauson CL, Sowa GA, Ngo K, Dong Q, Pola E, Lee JY, Niedernhofer LJ, Kang JD, Robbins PD, Vo NV.

Spine (Phila Pa 1976). 2012 Oct 1;37(21):1819-25. Erratum in: Spine (Phila Pa 1976). 2013 Jan 1;38(1):E48.

PMID:
22343279
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.

Ahmad A, Enzlin JH, Bhagwat NR, Wijgers N, Raams A, Appledoorn E, Theil AF, J Hoeijmakers JH, Vermeulen W, J Jaspers NG, Schärer OD, Niedernhofer LJ.

PLoS Genet. 2010 Mar 5;6(3):e1000871. doi: 10.1371/journal.pgen.1000871.

PMID:
20221251
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene.

Selfridge J, Hsia KT, Redhead NJ, Melton DW.

Nucleic Acids Res. 2001 Nov 15;29(22):4541-50.

PMID:
11713303
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Smad4 loss in mouse keratinocytes leads to increased susceptibility to UV carcinogenesis with reduced Ercc1-mediated DNA repair.

Mitra D, Fernandez P, Bian L, Song N, Li F, Han G, Wang XJ.

J Invest Dermatol. 2013 Nov;133(11):2609-16. doi: 10.1038/jid.2013.213. Epub 2013 May 6.

PMID:
23648546
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model.

Matoka DJ, Yao V, Harya DS, Gregg JL, Robinson AR, Niedernhofer LJ, Parwani AV, Maier C, Bacich DJ.

Prostate. 2012 Aug 1;72(11):1214-22. doi: 10.1002/pros.22472. Epub 2011 Dec 27.

PMID:
22212909
[PubMed - indexed for MEDLINE]
Free PMC Article
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