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Results: 1 to 20 of 114

1.

Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists.

Deng H, Hu H, He M, Hu J, Niu W, Ferrie AM, Fang Y.

J Med Chem. 2011 Oct 27;54(20):7385-96. doi: 10.1021/jm200999f. Epub 2011 Oct 4.

PMID:
21950657
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Thieno[3,2-b]thiophene-2-carboxylic acid derivatives as GPR35 agonists.

Deng H, Hu J, Hu H, He M, Fang Y.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4148-52. doi: 10.1016/j.bmcl.2012.04.057. Epub 2012 Apr 21.

PMID:
22572579
[PubMed - indexed for MEDLINE]
3.

Tyrphostin analogs are GPR35 agonists.

Deng H, Hu H, Fang Y.

FEBS Lett. 2011 Jun 23;585(12):1957-62. doi: 10.1016/j.febslet.2011.05.026. Epub 2011 May 17.

PMID:
21601572
[PubMed - indexed for MEDLINE]
Free Article
4.

High-throughput identification and characterization of novel, species-selective GPR35 agonists.

Neetoo-Isseljee Z, MacKenzie AE, Southern C, Jerman J, McIver EG, Harries N, Taylor DL, Milligan G.

J Pharmacol Exp Ther. 2013 Mar;344(3):568-78. doi: 10.1124/jpet.112.201798. Epub 2012 Dec 21.

PMID:
23262279
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

Jenkins L, Alvarez-Curto E, Campbell K, de Munnik S, Canals M, Schlyer S, Milligan G.

Br J Pharmacol. 2011 Feb;162(3):733-48. doi: 10.1111/j.1476-5381.2010.01082.x.

PMID:
20958291
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.

Jenkins L, Brea J, Smith NJ, Hudson BD, Reilly G, Bryant NJ, Castro M, Loza MI, Milligan G.

Biochem J. 2010 Dec 15;432(3):451-9. doi: 10.1042/BJ20101287.

PMID:
20919992
[PubMed - indexed for MEDLINE]
Free Article
7.

8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.

Funke M, Thimm D, Schiedel AC, Müller CE.

J Med Chem. 2013 Jun 27;56(12):5182-97. doi: 10.1021/jm400587g. Epub 2013 Jun 17.

PMID:
23713606
[PubMed - indexed for MEDLINE]
8.

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action.

Jenkins L, Harries N, Lappin JE, MacKenzie AE, Neetoo-Isseljee Z, Southern C, McIver EG, Nicklin SA, Taylor DL, Milligan G.

J Pharmacol Exp Ther. 2012 Dec;343(3):683-95. doi: 10.1124/jpet.112.198945. Epub 2012 Sep 11.

PMID:
22967846
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Label-free phenotypic profiling identified D-luciferin as a GPR35 agonist.

Hu H, Deng H, Fang Y.

PLoS One. 2012;7(4):e34934. doi: 10.1371/journal.pone.0034934. Epub 2012 Apr 12.

PMID:
22511974
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.

Zhao P, Sharir H, Kapur A, Cowan A, Geller EB, Adler MW, Seltzman HH, Reggio PH, Heynen-Genel S, Sauer M, Chung TD, Bai Y, Chen W, Caron MG, Barak LS, Abood ME.

Mol Pharmacol. 2010 Oct;78(4):560-8. doi: 10.1124/mol.110.066746. Epub 2010 Jul 22.

PMID:
20826425
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Multiple tyrosine metabolites are GPR35 agonists.

Deng H, Hu H, Fang Y.

Sci Rep. 2012;2:373. doi: 10.1038/srep00373. Epub 2012 Apr 20.

PMID:
22523636
[PubMed]
Free PMC Article
12.

Novel cyano- and N-isopropylamidino-substituted derivatives of benzo[b]thiophene-2-carboxanilides and benzo[b]thieno[2,3-c]quinolones: synthesis, photochemical synthesis, crystal structure determination, and antitumor evaluation. 2.

Jarak I, Kralj M, Suman L, Pavlović G, Dogan J, Piantanida I, Zinić M, Pavelić K, Karminski-Zamola G.

J Med Chem. 2005 Apr 7;48(7):2346-60.

PMID:
15801828
[PubMed - indexed for MEDLINE]
13.

Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues.

Deng H, Fang Y.

ACS Med Chem Lett. 2012 Jun 6;3(7):550-4. doi: 10.1021/ml300076u. eCollection 2012 Jul 12.

PMID:
24900508
[PubMed]
Free PMC Article
14.

6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.

Thimm D, Funke M, Meyer A, Müller CE.

J Med Chem. 2013 Sep 12;56(17):7084-99. doi: 10.1021/jm4009373. Epub 2013 Aug 15.

PMID:
23888932
[PubMed - indexed for MEDLINE]
15.

Anti-inflammatory gallic Acid and wedelolactone are G protein-coupled receptor-35 agonists.

Deng H, Fang Y.

Pharmacology. 2012;89(3-4):211-9. doi: 10.1159/000337184. Epub 2012 Apr 4.

PMID:
22488351
[PubMed - indexed for MEDLINE]
16.

5-Nitro-2-(3-phenylpropylamino)benzoic acid is a GPR35 agonist.

Taniguchi Y, Tonai-Kachi H, Shinjo K.

Pharmacology. 2008;82(4):245-9. doi: 10.1159/000157625. Epub 2008 Sep 26.

PMID:
18818509
[PubMed - indexed for MEDLINE]
17.

Crucial positively charged residues for ligand activation of the GPR35 receptor.

Zhao P, Lane TR, Gao HG, Hurst DP, Kotsikorou E, Le L, Brailoiu E, Reggio PH, Abood ME.

J Biol Chem. 2014 Feb 7;289(6):3625-38. doi: 10.1074/jbc.M113.508382. Epub 2013 Dec 17.

PMID:
24347166
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Synthesis, photochemical synthesis, DNA binding and antitumor evaluation of novel cyano- and amidino-substituted derivatives of naphtho-furans, naphtho-thiophenes, thieno-benzofurans, benzo-dithiophenes and their acyclic precursors.

Starcević K, Kralj M, Piantanida I, Suman L, Pavelić K, Karminski-Zamola G.

Eur J Med Chem. 2006 Aug;41(8):925-39. Epub 2006 May 2.

PMID:
16650510
[PubMed - indexed for MEDLINE]
19.

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35.

MacKenzie AE, Caltabiano G, Kent TC, Jenkins L, McCallum JE, Hudson BD, Nicklin SA, Fawcett L, Markwick R, Charlton SJ, Milligan G.

Mol Pharmacol. 2014 Jan;85(1):91-104. doi: 10.1124/mol.113.089482. Epub 2013 Oct 10.

PMID:
24113750
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium.

Yang Y, Lu JY, Wu X, Summer S, Whoriskey J, Saris C, Reagan JD.

Pharmacology. 2010;86(1):1-5. doi: 10.1159/000314164. Epub 2010 Jun 19.

PMID:
20559017
[PubMed - indexed for MEDLINE]
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