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The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis.

Ng TL, Leprivier G, Robertson MD, Chow C, Martin MJ, Laderoute KR, Davicioni E, Triche TJ, Sorensen PH.

Cell Death Differ. 2012 Mar;19(3):501-10. doi: 10.1038/cdd.2011.119. Epub 2011 Sep 23.


Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.

Nagalingam A, Arbiser JL, Bonner MY, Saxena NK, Sharma D.

Breast Cancer Res. 2012 Feb 21;14(1):R35.


Energy depletion of bovine mammary epithelial cells activates AMPK and suppresses protein synthesis through inhibition of mTORC1 signaling.

Burgos SA, Kim JJ, Dai M, Cant JP.

Horm Metab Res. 2013 Mar;45(3):183-9. doi: 10.1055/s-0032-1323742. Epub 2012 Sep 12.


Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity by modulating the TSC1/TSC2-Rheb GTPase pathway.

Yoshida S, Hong S, Suzuki T, Nada S, Mannan AM, Wang J, Okada M, Guan KL, Inoki K.

J Biol Chem. 2011 Sep 16;286(37):32651-60. doi: 10.1074/jbc.M111.238014. Epub 2011 Jul 22.


Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.

Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA.

Oncogene. 2013 Oct 10;32(41):4932-40. doi: 10.1038/onc.2012.512. Epub 2012 Nov 19.


Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.

Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.

Mol Cell Biol. 2011 May;31(9):1870-84. doi: 10.1128/MCB.01393-10. Epub 2011 Mar 7.


Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK.

White JP, Puppa MJ, Gao S, Sato S, Welle SL, Carson JA.

Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1042-52. doi: 10.1152/ajpendo.00410.2012. Epub 2013 Mar 26.


AMP-activated protein kinase suppresses matrix metalloproteinase-9 expression in mouse embryonic fibroblasts.

Morizane Y, Thanos A, Takeuchi K, Murakami Y, Kayama M, Trichonas G, Miller J, Foretz M, Viollet B, Vavvas DG.

J Biol Chem. 2011 May 6;286(18):16030-8. doi: 10.1074/jbc.M110.199398. Epub 2011 Mar 14.


The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.

Lin A, Yao J, Zhuang L, Wang D, Han J, Lam EW, Gan B.

Oncogene. 2014 Jun 12;33(24):3183-94. doi: 10.1038/onc.2013.273. Epub 2013 Jul 15. Erratum in: Oncogene. 2014 Nov 6;33(45):5310. TCGA Research Network [removed].


Ionizing radiation regulates the expression of AMP-activated protein kinase (AMPK) in epithelial cancer cells: modulation of cellular signals regulating cell cycle and survival.

Sanli T, Storozhuk Y, Linher-Melville K, Bristow RG, Laderout K, Viollet B, Wright J, Singh G, Tsakiridis T.

Radiother Oncol. 2012 Mar;102(3):459-65. doi: 10.1016/j.radonc.2011.11.014. Epub 2012 Jan 5.


The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

Martin MJ, Melnyk N, Pollard M, Bowden M, Leong H, Podor TJ, Gleave M, Sorensen PH.

Mol Cell Biol. 2006 Mar;26(5):1754-69.


Antagonistic control of muscle cell size by AMPK and mTORC1.

Mounier R, Lantier L, Leclerc J, Sotiropoulos A, Foretz M, Viollet B.

Cell Cycle. 2011 Aug 15;10(16):2640-6. Epub 2011 Aug 15.


A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation.

Amatya PN, Kim HB, Park SJ, Youn CK, Hyun JW, Chang IY, Lee JH, You HJ.

Biochim Biophys Acta. 2012 Dec;1823(12):2099-108. doi: 10.1016/j.bbamcr.2012.08.022. Epub 2012 Sep 7.


Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.

Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E, Prica M, Harhaji-Trajkovic L, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V.

Autophagy. 2011 Jan;7(1):40-50. Epub 2011 Jan 1.


AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor.

Liu JL, Mao Z, Gallick GE, Yung WK.

Neuro Oncol. 2011 Feb;13(2):184-94. doi: 10.1093/neuonc/noq163. Epub 2010 Dec 1.


mTORC1 is a target of nordihydroguaiaretic acid to prevent breast tumor growth in vitro and in vivo.

Zhang Y, Xu S, Lin J, Yao G, Han Z, Liang B, Zou Z, Chen Z, Song Q, Dai Y, Gao T, Liu A, Bai X.

Breast Cancer Res Treat. 2012 Nov;136(2):379-88. doi: 10.1007/s10549-012-2270-7. Epub 2012 Sep 29.

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