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Results: 1 to 20 of 103

1.

Inhibition of benzalkonium chloride-induced skin inflammation in mice by an indol-1-ylpropan-2-one inhibitor of cytosolic phospholipase A2 α.

Roebrock K, Wolf M, Bovens S, Lehr M, Sunderkötter C.

Br J Dermatol. 2012 Feb;166(2):306-16. doi: 10.1111/j.1365-2133.2011.10637.x. Epub 2011 Dec 6.

PMID:
21929537
[PubMed - indexed for MEDLINE]
2.

Inhibitory effect of a potent and selective cytosolic phospholipase A2alpha inhibitor RSC-3388 on skin inflammation in mice.

Yamamoto M, Haruna T, Imura K, Hikita I, Furue Y, Higashino K, Gahara Y, Deguchi M, Yasui K, Arimura A.

Pharmacology. 2008;81(4):301-11. doi: 10.1159/000117816. Epub 2008 Feb 21.

PMID:
18287786
[PubMed - indexed for MEDLINE]
3.

1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase.

Forster L, Ludwig J, Kaptur M, Bovens S, Elfringhoff AS, Holtfrerich A, Lehr M.

Bioorg Med Chem. 2010 Jan 15;18(2):945-52. doi: 10.1016/j.bmc.2009.11.028. Epub 2009 Nov 17.

PMID:
20005725
[PubMed - indexed for MEDLINE]
4.

1-(5-carboxyindol-1-yl)propan-2-one inhibitors of human cytosolic phospholipase A(2)alpha with reduced lipophilicity: synthesis, biological activity, metabolic stability, solubility, bioavailability, and topical in vivo activity.

Drews A, Bovens S, Roebrock K, Sunderkötter C, Reinhardt D, Schäfers M, van der Velde A, Schulze Elfringhoff A, Fabian J, Lehr M.

J Med Chem. 2010 Jul 22;53(14):5165-78. doi: 10.1021/jm1001088.

PMID:
20583844
[PubMed - indexed for MEDLINE]
5.

Topical application of silymarin reduces chemical-induced irritant contact dermatitis in BALB/c mice.

Han MH, Yoon WK, Lee H, Han SB, Lee K, Park SK, Yang KH, Kim HM, Kang JS.

Int Immunopharmacol. 2007 Dec 15;7(13):1651-8. Epub 2007 Sep 14.

PMID:
17996674
[PubMed - indexed for MEDLINE]
6.

1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds as dual inhibitors of human cytosolic phospholipase A2α and fatty acid amide hydrolase.

Zahov S, Drews A, Hess M, Schulze Elfringhoff A, Lehr M.

ChemMedChem. 2011 Mar 7;6(3):544-9. doi: 10.1002/cmdc.201000473. Epub 2011 Jan 21.

PMID:
21259444
[PubMed - indexed for MEDLINE]
7.

Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin.

Wilmer JL, Burleson FG, Kayama F, Kanno J, Luster MI.

J Invest Dermatol. 1994 Jun;102(6):915-22.

PMID:
8006454
[PubMed - indexed for MEDLINE]
8.

Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.

Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM, Feingold KR.

J Invest Dermatol. 2003 Feb;120(2):246-55.

PMID:
12542530
[PubMed - indexed for MEDLINE]
Free Article
9.

Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.

Sheu MY, Fowler AJ, Kao J, Schmuth M, Schoonjans K, Auwerx J, Fluhr JW, Man MQ, Elias PM, Feingold KR.

J Invest Dermatol. 2002 Jan;118(1):94-101.

PMID:
11851881
[PubMed - indexed for MEDLINE]
Free Article
10.

Cytosolic phospholipase A2α blockade abrogates disease during the tissue-damage effector phase of experimental autoimmune encephalomyelitis by its action on APCs.

Thakker P, Marusic S, Stedman NL, Lee KL, McKew JC, Wood A, Goldman SJ, Leach MW, Collins M, Kuchroo VK, Wolf SF, Clark JD, Hassan-Zahraee M.

J Immunol. 2011 Aug 15;187(4):1986-97. doi: 10.4049/jimmunol.1002789. Epub 2011 Jul 11.

PMID:
21746963
[PubMed - indexed for MEDLINE]
Free Article
11.

Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear.

Yeom M, Kim SH, Lee B, Han JJ, Chung GH, Choi HD, Lee H, Hahm DH.

J Dermatol Sci. 2012 Aug;67(2):101-10. doi: 10.1016/j.jdermsci.2012.05.009. Epub 2012 Jun 7.

PMID:
22726258
[PubMed - indexed for MEDLINE]
12.

Thermodynamic characterization of cytosolic phospholipase A2 alpha inhibitors.

Ramarao MK, Shen MW, Murphy EA, Duan W, Zhao Y, McKew J, Lee KL, Thakker P, Behnke ML, Clark JD.

Anal Biochem. 2008 Dec 15;383(2):217-25. doi: 10.1016/j.ab.2008.08.025. Epub 2008 Aug 30.

PMID:
18801329
[PubMed - indexed for MEDLINE]
13.

IL-6 deficiency exacerbates skin inflammation in a murine model of irritant dermatitis.

Lee EG, Mickle-Kawar BM, Gallucci RM.

J Immunotoxicol. 2013 Apr-Jun;10(2):192-200. doi: 10.3109/1547691X.2012.707700. Epub 2012 Sep 11.

PMID:
22966985
[PubMed - indexed for MEDLINE]
14.

Differential induction of cutaneous TNF-alpha and IL-6 by topically applied chemicals.

Holliday MR, Corsini E, Smith S, Basketter DA, Dearman RJ, Kimber I.

Am J Contact Dermat. 1997 Sep;8(3):158-64.

PMID:
9249285
[PubMed - indexed for MEDLINE]
15.

Topical valrubicin application reduces skin inflammation in murine models.

Hauge E, Christiansen H, Rosada C, de Darkó E, Dam TN, Stenderup K.

Br J Dermatol. 2012 Aug;167(2):288-95. doi: 10.1111/j.1365-2133.2012.10964.x. Epub 2012 Jul 5.

PMID:
22458650
[PubMed - indexed for MEDLINE]
16.

Antioxidants attenuate anthralin-induced skin inflammation in BALB/c mice: role of specific proinflammatory cytokines.

Lange RW, Germolec DR, Foley JF, Luster MI.

J Leukoc Biol. 1998 Aug;64(2):170-6.

PMID:
9715255
[PubMed - indexed for MEDLINE]
Free Article
17.

Characterization of a novel inhibitor of cytosolic phospholipase A2alpha, pyrrophenone.

Ono T, Yamada K, Chikazawa Y, Ueno M, Nakamoto S, Okuno T, Seno K.

Biochem J. 2002 May 1;363(Pt 3):727-35.

PMID:
11964173
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Cytosolic phospholipase A2alpha regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation.

Sapirstein A, Saito H, Texel SJ, Samad TA, O'Leary E, Bonventre JV.

Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1774-82. Epub 2005 Feb 17.

PMID:
15718387
[PubMed - indexed for MEDLINE]
19.

Investigations on the metabolic stability of cytosolic phospholipase A2α inhibitors with 1-indolylpropan-2-one structure.

Fabian J, Hanekamp W, Thomas MH, Olivier JL, Lehr M.

Chem Biol Interact. 2013 Nov 25;206(2):356-63. doi: 10.1016/j.cbi.2013.10.005. Epub 2013 Oct 10.

PMID:
24120545
[PubMed - indexed for MEDLINE]
20.

Effects of the inhibition of cytosolic phospholipase A(2)α in non-small cell lung cancer cells.

Sundarraj S, Kannan S, Thangam R, Gunasekaran P.

J Cancer Res Clin Oncol. 2012 May;138(5):827-35. doi: 10.1007/s00432-012-1157-7. Epub 2012 Jan 25.

PMID:
22274867
[PubMed - indexed for MEDLINE]

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