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Hyperglycemia-induced proliferation of adult human beta cells engrafted into spontaneously diabetic immunodeficient NOD-Rag1null IL2rγnull Ins2Akita mice.

Diiorio P, Jurczyk A, Yang C, Racki WJ, Brehm MA, Atkinson MA, Powers AC, Shultz LD, Greiner DL, Bortell R.

Pancreas. 2011 Oct;40(7):1147-9. doi: 10.1097/MPA.0b013e31821ffabe. No abstract available.


A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.

Pearson T, Shultz LD, Lief J, Burzenski L, Gott B, Chase T, Foreman O, Rossini AA, Bottino R, Trucco M, Greiner DL.

Diabetologia. 2008 Aug;51(8):1449-56. doi: 10.1007/s00125-008-1057-1. Epub 2008 Jun 19.


Human immune system development and rejection of human islet allografts in spontaneously diabetic NOD-Rag1null IL2rgammanull Ins2Akita mice.

Brehm MA, Bortell R, Diiorio P, Leif J, Laning J, Cuthbert A, Yang C, Herlihy M, Burzenski L, Gott B, Foreman O, Powers AC, Greiner DL, Shultz LD.

Diabetes. 2010 Sep;59(9):2265-70. doi: 10.2337/db10-0323. Epub 2010 Jun 22.


Humanized mice for the study of type 1 and type 2 diabetes.

Greiner DL, Brehm MA, Hosur V, Harlan DM, Powers AC, Shultz LD.

Ann N Y Acad Sci. 2011 Dec;1245:55-8. doi: 10.1111/j.1749-6632.2011.06318.x.


New mouse model to study islet transplantation in insulin-dependent diabetes mellitus.

Mathews CE, Langley SH, Leiter EH.

Transplantation. 2002 Apr 27;73(8):1333-6.


A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.

King M, Pearson T, Shultz LD, Leif J, Bottino R, Trucco M, Atkinson MA, Wasserfall C, Herold KC, Woodland RT, Schmidt MR, Woda BA, Thompson MJ, Rossini AA, Greiner DL.

Clin Immunol. 2008 Mar;126(3):303-14. Epub 2007 Dec 21.


Enhancement of beta-cell regeneration by islet transplantation after partial pancreatectomy in mice.

Jung HS, Ahn YR, Oh SH, Kim YS, No H, Lee MK, Kim KW.

Transplantation. 2009 Aug 15;88(3):354-9. doi: 10.1097/TP.0b013e3181b07a02.


Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.

Banuelos SJ, Shultz LD, Greiner DL, Burzenski LM, Gott B, Lyons BL, Rossini AA, Appel MC.

Clin Immunol. 2004 Sep;112(3):273-83.


Pancreatic insulin-producing cells differentiated from human embryonic stem cells correct hyperglycemia in SCID/NOD mice, an animal model of diabetes.

Hua XF, Wang YW, Tang YX, Yu SQ, Jin SH, Meng XM, Li HF, Liu FJ, Sun Q, Wang HY, Li JY.

PLoS One. 2014 Jul 10;9(7):e102198. doi: 10.1371/journal.pone.0102198. eCollection 2014.


Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment.

Pearson T, Shultz LD, Miller D, King M, Laning J, Fodor W, Cuthbert A, Burzenski L, Gott B, Lyons B, Foreman O, Rossini AA, Greiner DL.

Clin Exp Immunol. 2008 Nov;154(2):270-84. doi: 10.1111/j.1365-2249.2008.03753.x. Epub 2008 Sep 8.


Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice.

Kajiyama H, Hamazaki TS, Tokuhara M, Masui S, Okabayashi K, Ohnuma K, Yabe S, Yasuda K, Ishiura S, Okochi H, Asashima M.

Int J Dev Biol. 2010;54(4):699-705. doi: 10.1387/ijdb.092953hk.


In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.

Hu He KH, Lorenzo PI, Brun T, Jimenez Moreno CM, Aeberhard D, Vallejo Ortega J, Cornu M, Thorel F, Gjinovci A, Thorens B, Herrera PL, Meda P, Wollheim CB, Gauthier BR.

Diabetes. 2011 Jun;60(6):1705-15. doi: 10.2337/db10-1102. Epub 2011 Apr 26.


Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of beta cells.

Enzler T, Gillessen S, Dougan M, Allison JP, Neuberg D, Oble DA, Mihm M, Dranoff G.

Blood. 2007 Aug 1;110(3):954-61. Epub 2007 May 4.


Dissociation of lipotoxicity and glucotoxicity in a mouse model of obesity associated diabetes: role of forkhead box O1 (FOXO1) in glucose-induced beta cell failure.

Kluth O, Mirhashemi F, Scherneck S, Kaiser D, Kluge R, Neschen S, Joost HG, Schürmann A.

Diabetologia. 2011 Mar;54(3):605-16. doi: 10.1007/s00125-010-1973-8. Epub 2010 Nov 24.


Increased expression of the glucose-responsive gene, RCAN1, causes hypoinsulinemia, β-cell dysfunction, and diabetes.

Peiris H, Raghupathi R, Jessup CF, Zanin MP, Mohanasundaram D, Mackenzie KD, Chataway T, Clarke JN, Brealey J, Coates PT, Pritchard MA, Keating DJ.

Endocrinology. 2012 Nov;153(11):5212-21. doi: 10.1210/en.2011-2149. Epub 2012 Sep 25.


Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.

Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P.

Transplantation. 2009 Apr 15;87(7):983-91. doi: 10.1097/TP.0b013e31819c86ea.


Transplantation of insulin-producing cells differentiated from human periosteum-derived progenitor cells ameliorate hyperglycemia in diabetic mice.

Dao LT, Park EY, Lim SM, Choi YS, Jung HS, Jun HS.

Transplantation. 2014 Nov 27;98(10):1040-7. doi: 10.1097/TP.0000000000000388.


The orphan nuclear receptor small heterodimer partner negatively regulates pancreatic beta cell survival and hyperglycemia in multiple low-dose streptozotocin-induced type 1 diabetic mice.

Noh JR, Hwang JH, Kim YH, Kim KS, Gang GT, Kim SW, Kim DK, Shong M, Lee IK, Choi HS, Lee CH.

Int J Biochem Cell Biol. 2013 Aug;45(8):1538-45. doi: 10.1016/j.biocel.2013.05.004. Epub 2013 May 13.


Transplantation of insulin-producing cells derived from umbilical cord stromal mesenchymal stem cells to treat NOD mice.

Wang HS, Shyu JF, Shen WS, Hsu HC, Chi TC, Chen CP, Huang SW, Shyr YM, Tang KT, Chen TH.

Cell Transplant. 2011;20(3):455-66. doi: 10.3727/096368910X522270. Epub 2010 Aug 18.

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