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Results: 1 to 20 of 97

1.

PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, FcRn.

Mezo AR, Low SC, Hoehn T, Palmieri H.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6332-5. doi: 10.1016/j.bmcl.2011.08.111. Epub 2011 Aug 31.

PMID:
21920737
[PubMed - indexed for MEDLINE]
2.

Synthesis and structure-activity relationships of dimeric peptide antagonists of the human immunoglobulin G-human neonatal Fc receptor (IgG-FcRn) interaction.

McDonnell KA, Low SC, Hoehn T, Donnelly R, Palmieri H, Fraley C, Sakorafas P, Mezo AR.

J Med Chem. 2010 Feb 25;53(4):1587-96. doi: 10.1021/jm901128z.

PMID:
20092334
[PubMed - indexed for MEDLINE]
3.

Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn.

Mezo AR, McDonnell KA, Hehir CA, Low SC, Palombella VJ, Stattel JM, Kamphaus GD, Fraley C, Zhang Y, Dumont JA, Bitonti AJ.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2337-42. doi: 10.1073/pnas.0708960105. Epub 2008 Feb 12.

PMID:
18272495
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn.

Mezo AR, Sridhar V, Badger J, Sakorafas P, Nienaber V.

J Biol Chem. 2010 Sep 3;285(36):27694-701. doi: 10.1074/jbc.M110.120667. Epub 2010 Jun 30.

PMID:
20592032
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction.

Mezo AR, McDonnell KA, Castro A, Fraley C.

Bioorg Med Chem. 2008 Jun 15;16(12):6394-405. doi: 10.1016/j.bmc.2008.05.004. Epub 2008 May 6.

PMID:
18501614
[PubMed - indexed for MEDLINE]
6.

Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.

Andersen JT, Daba MB, Berntzen G, Michaelsen TE, Sandlie I.

J Biol Chem. 2010 Feb 12;285(7):4826-36. doi: 10.1074/jbc.M109.081828. Epub 2009 Dec 14.

PMID:
20018855
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Characterization of site-specific ScFv PEGylation for tumor-targeting pharmaceuticals.

Natarajan A, Xiong CY, Albrecht H, DeNardo GL, DeNardo SJ.

Bioconjug Chem. 2005 Jan-Feb;16(1):113-21.

PMID:
15656582
[PubMed - indexed for MEDLINE]
8.

Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC.

Int Immunol. 2006 Dec;18(12):1759-69. Epub 2006 Oct 31.

PMID:
17077181
[PubMed - indexed for MEDLINE]
Free Article
9.
10.

PEG-doxorubicin conjugates: influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity.

Veronese FM, Schiavon O, Pasut G, Mendichi R, Andersson L, Tsirk A, Ford J, Wu G, Kneller S, Davies J, Duncan R.

Bioconjug Chem. 2005 Jul-Aug;16(4):775-84.

PMID:
16029018
[PubMed - indexed for MEDLINE]
11.

Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,).

West AP Jr, Bjorkman PJ.

Biochemistry. 2000 Aug 15;39(32):9698-708.

PMID:
10933786
[PubMed - indexed for MEDLINE]
12.

Prolonged circulating lives of single-chain Fv proteins conjugated with polyethylene glycol: a comparison of conjugation chemistries and compounds.

Lee LS, Conover C, Shi C, Whitlow M, Filpula D.

Bioconjug Chem. 1999 Nov-Dec;10(6):973-81.

PMID:
10563766
[PubMed - indexed for MEDLINE]
13.

Biological activities of polyethylene-glycol immunoglobulin conjugates. Resistance to enzymatic degradation.

Cunningham-Rundles C, Zhuo Z, Griffith B, Keenan J.

J Immunol Methods. 1992 Aug 10;152(2):177-90.

PMID:
1500728
[PubMed - indexed for MEDLINE]
14.

Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins.

Saifer MG, Williams LD, Sobczyk MA, Michaels SJ, Sherman MR.

Mol Immunol. 2014 Feb;57(2):236-46. doi: 10.1016/j.molimm.2013.07.014. Epub 2013 Nov 5.

PMID:
24200843
[PubMed - indexed for MEDLINE]
Free Article
15.

Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction.

Wang Z, Fraley C, Mezo AR.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1253-6. doi: 10.1016/j.bmcl.2013.01.014. Epub 2013 Jan 11.

PMID:
23375228
[PubMed - indexed for MEDLINE]
16.

Improved pharmacokinetics and reduced antibody reactivity of lysostaphin conjugated to polyethylene glycol.

Walsh S, Shah A, Mond J.

Antimicrob Agents Chemother. 2003 Feb;47(2):554-8.

PMID:
12543658
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Crystal structure of the complex of rat neonatal Fc receptor with Fc.

Burmeister WP, Huber AH, Bjorkman PJ.

Nature. 1994 Nov 24;372(6504):379-83.

PMID:
7969498
[PubMed - indexed for MEDLINE]
18.
19.

Pharmacokinetic, biodistribution, and biophysical profiles of TNF nanobodies conjugated to linear or branched poly(ethylene glycol).

Vugmeyster Y, Entrican CA, Joyce AP, Lawrence-Henderson RF, Leary BA, Mahoney CS, Patel HK, Raso SW, Olland SH, Hegen M, Xu X.

Bioconjug Chem. 2012 Jul 18;23(7):1452-62. doi: 10.1021/bc300066a. Epub 2012 Jun 25.

PMID:
22731748
[PubMed - indexed for MEDLINE]
20.

Monocyte/macrophage interactions with base and linear- and star-like PEG-modified PEG-poly(acrylic acid) co-polymers.

Wagner VE, Bryers JD.

J Biomed Mater Res A. 2003 Jul 1;66(1):62-78.

PMID:
12833432
[PubMed - indexed for MEDLINE]

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