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Items: 1 to 20 of 138

1.

Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays.

Semenova MN, Kiselyov AS, Tsyganov DV, Konyushkin LD, Firgang SI, Semenov RV, Malyshev OR, Raihstat MM, Fuchs F, Stielow A, Lantow M, Philchenkov AA, Zavelevich MP, Zefirov NS, Kuznetsov SA, Semenov VV.

J Med Chem. 2011 Oct 27;54(20):7138-49. doi: 10.1021/jm200737s. Epub 2011 Sep 29.

PMID:
21916509
2.

Synthesis and comparative evaluation of 4-oxa- and 4-aza-podophyllotoxins as antiproliferative microtubule destabilizing agents.

Chernysheva NB, Tsyganov DV, Philchenkov AA, Zavelevich MP, Kiselyov AS, Semenov RV, Semenova MN, Semenov VV.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2590-3. doi: 10.1016/j.bmcl.2012.01.128. Epub 2012 Feb 9.

PMID:
22370267
3.

cis-Restricted 3-aminopyrazole analogues of combretastatins: synthesis from plant polyalkoxybenzenes and biological evaluation in the cytotoxicity and phenotypic sea urchin embryo assays.

Tsyganov DV, Konyushkin LD, Karmanova IB, Firgang SI, Strelenko YA, Semenova MN, Kiselyov AS, Semenov VV.

J Nat Prod. 2013 Aug 23;76(8):1485-91. doi: 10.1021/np400310m. Epub 2013 Aug 7.

PMID:
23924236
4.

Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays.

Kiselyov AS, Semenova MN, Chernyshova NB, Leitao A, Samet AV, Kislyi KA, Raihstat MM, Oprea T, Lemcke H, Lantow M, Weiss DG, Ikizalp NN, Kuznetsov SA, Semenov VV.

Eur J Med Chem. 2010 May;45(5):1683-97. doi: 10.1016/j.ejmech.2009.12.072. Epub 2010 Jan 14.

PMID:
20110137
5.

Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

Abad A, López-Pérez JL, del Olmo E, García-Fernández LF, Francesch A, Trigili C, Barasoain I, Andreu JM, Díaz JF, San Feliciano A.

J Med Chem. 2012 Aug 9;55(15):6724-37. doi: 10.1021/jm2017573. Epub 2012 Jul 23.

PMID:
22607205
6.

Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents.

Kamal A, Suresh P, Mallareddy A, Kumar BA, Reddy PV, Raju P, Tamboli JR, Shaik TB, Jain N, Kalivendi SV.

Bioorg Med Chem. 2011 Apr 1;19(7):2349-58. doi: 10.1016/j.bmc.2011.02.020. Epub 2011 Feb 24.

PMID:
21402478
7.

Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.

Semenova MN, Tsyganov DV, Malyshev OR, Ershov OV, Bardasov IN, Semenov RV, Kiselyov AS, Semenov VV.

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3914-8. doi: 10.1016/j.bmcl.2014.06.043. Epub 2014 Jun 25. Erratum in: Bioorg Med Chem Lett. 2015 Apr 1;25(7):1653-4.

PMID:
24997684
8.

Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines.

Demchuk DV, Samet AV, Chernysheva NB, Ushkarov VI, Stashina GA, Konyushkin LD, Raihstat MM, Firgang SI, Philchenkov AA, Zavelevich MP, Kuiava LM, Chekhun VF, Blokhin DY, Kiselyov AS, Semenova MN, Semenov VV.

Bioorg Med Chem. 2014 Jan 15;22(2):738-55. doi: 10.1016/j.bmc.2013.12.015. Epub 2013 Dec 12.

PMID:
24387982
9.
10.

3-(5-)-Amino-o-diarylisoxazoles: regioselective synthesis and antitubulin activity.

Tsyganov DV, Khrustalev VN, Konyushkin LD, Raihstat MM, Firgang SI, Semenov RV, Kiselyov AS, Semenova MN, Semenov VV.

Eur J Med Chem. 2014 Feb 12;73:112-25. doi: 10.1016/j.ejmech.2013.12.006. Epub 2013 Dec 16.

PMID:
24388833
11.

Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.

Kamal A, Tamboli JR, Nayak VL, Adil SF, Vishnuvardhan MV, Ramakrishna S.

Bioorg Med Chem. 2014 May 1;22(9):2714-23. doi: 10.1016/j.bmc.2014.03.021. Epub 2014 Mar 22.

PMID:
24721832
12.

Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents.

Kamal A, Mallareddy A, Suresh P, Shaik TB, Lakshma Nayak V, Kishor C, Shetti RV, Sankara Rao N, Tamboli JR, Ramakrishna S, Addlagatta A.

Bioorg Med Chem. 2012 Jun 1;20(11):3480-92. doi: 10.1016/j.bmc.2012.04.010. Epub 2012 Apr 10.

PMID:
22543234
13.

Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization.

Romagnoli R, Baraldi PG, Carrion MD, Lopez Cara C, Preti D, Fruttarolo F, Pavani MG, Tabrizi MA, Tolomeo M, Grimaudo S, Di Cristina A, Balzarini J, Hadfield JA, Brancale A, Hamel E.

J Med Chem. 2007 May 3;50(9):2273-7. Epub 2007 Apr 10.

PMID:
17419607
14.

Design and synthesis of resveratrol-based nitrovinylstilbenes as antimitotic agents.

Reddy MA, Jain N, Yada D, Kishore C, Vangala JR, P Surendra R, Addlagatta A, Kalivendi SV, Sreedhar B.

J Med Chem. 2011 Oct 13;54(19):6751-60. doi: 10.1021/jm200639r. Epub 2011 Sep 2.

PMID:
21851083
15.

Phenylcinnamides as novel antimitotic agents.

Leslie BJ, Holaday CR, Nguyen T, Hergenrother PJ.

J Med Chem. 2010 May 27;53(10):3964-72. doi: 10.1021/jm901805m.

PMID:
20411988
16.

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.

Bioorg Med Chem. 2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.

PMID:
23022053
17.

Pyrrolotetrazinones deazaanalogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition.

Viola G, Cecconet L, Leszl A, Basso G, Brun P, Salvador A, Dall'Acqua F, Diana P, Barraja P, Cirrincione G.

Cancer Chemother Pharmacol. 2009 Nov;64(6):1235-51. doi: 10.1007/s00280-009-0994-9. Epub 2009 Apr 11.

PMID:
19363609
18.

2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents.

Lo YH, Lin CC, Lin CF, Lin YT, Duh TH, Hong YR, Yang SH, Lin SR, Yang SC, Chang LS, Wu MJ.

J Med Chem. 2008 May 8;51(9):2682-8. doi: 10.1021/jm070820n. Epub 2008 Apr 3.

PMID:
18386884
19.

Discovery of novel 2-N-aryl-substituted benzenesulfonamidoacetamides: orally bioavailable tubulin polymerization inhibitors with marked antitumor activities.

Liu Z, Zhou Z, Tian W, Fan X, Xue D, Yu L, Yu Q, Long YQ.

ChemMedChem. 2012 Apr;7(4):680-93. doi: 10.1002/cmdc.201100529. Epub 2012 Feb 6.

PMID:
22311585
20.

Structure-activity relationship studies of 3-aroylindoles as potent antimitotic agents.

Liou JP, Mahindroo N, Chang CW, Guo FM, Lee SW, Tan UK, Yeh TK, Kuo CC, Chang YW, Lu PH, Tung YS, Lin KT, Chang JY, Hsieh HP.

ChemMedChem. 2006 Oct;1(10):1106-18.

PMID:
16952120
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