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Results: 1 to 20 of 129

1.

Synthesis of diastereomerically pure nucleotide phosphoramidates.

Ross BS, Reddy PG, Zhang HR, Rachakonda S, Sofia MJ.

J Org Chem. 2011 Oct 21;76(20):8311-9. doi: 10.1021/jo201492m. Epub 2011 Sep 26.

PMID:
21916475
[PubMed - indexed for MEDLINE]
2.

The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

McGuigan C, Perrone P, Madela K, Neyts J.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4316-20. doi: 10.1016/j.bmcl.2009.05.122. Epub 2009 Jun 10.

PMID:
19523820
[PubMed - indexed for MEDLINE]
3.

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, Niu C, Otto MJ, Furman PA.

J Med Chem. 2010 Oct 14;53(19):7202-18. doi: 10.1021/jm100863x.

PMID:
20845908
[PubMed - indexed for MEDLINE]
4.

Synthesis of stable isotope labeled analogs of the anti-hepatitis C virus nucleotide prodrugs PSI-7977 and PSI-352938.

Chun BK, Du J, Zhang HR, Chang W, Ross BS, Jiang Y, Bao D, Espiritu CL, Keilman M, Steuer HM, Furman PA, Sofia MJ.

Nucleosides Nucleotides Nucleic Acids. 2011 Nov;30(11):886-96. doi: 10.1080/15257770.2011.614308.

PMID:
22060553
[PubMed - indexed for MEDLINE]
5.

Aryloxy phosphoramidate triesters as pro-tides.

Cahard D, McGuigan C, Balzarini J.

Mini Rev Med Chem. 2004 May;4(4):371-81. Review.

PMID:
15134540
[PubMed - indexed for MEDLINE]
6.

Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.

Rondla R, Coats SJ, McBrayer TR, Grier J, Johns M, Tharnish PM, Whitaker T, Zhou L, Schinazi RF.

Antivir Chem Chemother. 2009 Oct 19;20(2):99-106. doi: 10.3851/1400.

PMID:
19843980
[PubMed - indexed for MEDLINE]
7.

Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

McGuigan C, Madela K, Aljarah M, Gilles A, Battina SK, Ramamurty CV, Srinivas Rao C, Vernachio J, Hutchins J, Hall A, Kolykhalov A, Henson G, Chamberlain S.

Bioorg Med Chem Lett. 2011 Oct 1;21(19):6007-12. doi: 10.1016/j.bmcl.2011.06.013. Epub 2011 Aug 17.

PMID:
21856153
[PubMed - indexed for MEDLINE]
8.

Model synthesis of nucleoside boranophosphoramidate with amino acid for prodrug purpose.

Li P, Shaw BR.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):675-8.

PMID:
16248012
[PubMed - indexed for MEDLINE]
9.

Phosphoramidate prodrugs deliver with potency against hepatitis C virus.

Mehellou Y.

ChemMedChem. 2010 Nov 8;5(11):1841-2. doi: 10.1002/cmdc.201000310. No abstract available.

PMID:
20865770
[PubMed - indexed for MEDLINE]
10.

Rapid differentiation of nucleotide phosphoramidate diastereomers by electrospray ionization tandem mass spectrometry.

Bao D, Reddy PG, Ross BS, Sofia MJ.

Rapid Commun Mass Spectrom. 2012 Aug 30;26(16):1887-92. doi: 10.1002/rcm.6307.

PMID:
22777791
[PubMed - indexed for MEDLINE]
11.

Synthesis of phosphoramidate prodrugs: ProTide approach.

Serpi M, Madela K, Pertusati F, Slusarczyk M.

Curr Protoc Nucleic Acid Chem. 2013 Jun;Chapter 15:Unit15.5. doi: 10.1002/0471142700.nc1505s53.

PMID:
23775807
[PubMed - indexed for MEDLINE]
12.

Synthesis and anti-herpetic activity of phosphoramidate ProTides.

Maiti M, Persoons L, Andrei G, Snoeck R, Balzarini J, Herdewijn P.

ChemMedChem. 2013 Jun;8(6):985-93. doi: 10.1002/cmdc.201300035. Epub 2013 Apr 18.

PMID:
23606629
[PubMed - indexed for MEDLINE]
13.

A novel synthesis of antiviral nucleoside phosphoramidate and thiophosphoramidate prodrugs via nucleoside H-phosphonamidates.

Sun Q, Li X, Gong S, Liu G, Shen L, Peng L.

Nucleosides Nucleotides Nucleic Acids. 2013;32(11):617-38. doi: 10.1080/15257770.2013.838262.

PMID:
24138500
[PubMed - indexed for MEDLINE]
14.

Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates.

Maiti M, Michielssens S, Dyubankova N, Maiti M, Lescrinier E, Ceulemans A, Herdewijn P.

Chemistry. 2012 Jan 16;18(3):857-68. doi: 10.1002/chem.201102279. Epub 2011 Dec 15.

PMID:
22173724
[PubMed - indexed for MEDLINE]
15.

Parallel solid-phase synthesis of nucleoside phosphoramidate libraries.

Jin Y, Chen X, Côté M, Roland A, Korba B, Mounir S, Iyer RP.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2057-60.

PMID:
11514138
[PubMed - indexed for MEDLINE]
16.

Activation mechanisms of nucleoside phosphoramidate prodrugs.

Freel Meyers CL, Borch RF.

J Med Chem. 2000 Nov 2;43(22):4319-27.

PMID:
11063626
[PubMed - indexed for MEDLINE]
17.

Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.

McGuigan C, Gilles A, Madela K, Aljarah M, Holl S, Jones S, Vernachio J, Hutchins J, Ames B, Bryant KD, Gorovits E, Ganguly B, Hunley D, Hall A, Kolykhalov A, Liu Y, Muhammad J, Raja N, Walters R, Wang J, Chamberlain S, Henson G.

J Med Chem. 2010 Jul 8;53(13):4949-57. doi: 10.1021/jm1003792.

PMID:
20527890
[PubMed - indexed for MEDLINE]
18.

Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.

Gardelli C, Attenni B, Donghi M, Meppen M, Pacini B, Harper S, Di Marco A, Fiore F, Giuliano C, Pucci V, Laufer R, Gennari N, Marcucci I, Leone JF, Olsen DB, MacCoss M, Rowley M, Narjes F.

J Med Chem. 2009 Sep 10;52(17):5394-407. doi: 10.1021/jm900447q.

PMID:
19725579
[PubMed - indexed for MEDLINE]
19.

Stereoselective synthesis of PSI-352938: a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV.

Reddy PG, Chun BK, Zhang HR, Rachakonda S, Ross BS, Sofia MJ.

J Org Chem. 2011 May 20;76(10):3782-90. doi: 10.1021/jo200060f. Epub 2011 Apr 19.

PMID:
21469736
[PubMed - indexed for MEDLINE]
20.

Designing a pronucleotide stratagem: lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines.

Drontle DP, Wagner CR.

Mini Rev Med Chem. 2004 May;4(4):409-19. Review.

PMID:
15134543
[PubMed - indexed for MEDLINE]
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