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Results: 1 to 20 of 152

1.

Activity in vivo of anti-Trypanosoma cruzi compounds selected from a high throughput screening.

Andriani G, Chessler AD, Courtemanche G, Burleigh BA, Rodriguez A.

PLoS Negl Trop Dis. 2011 Aug;5(8):e1298. doi: 10.1371/journal.pntd.0001298. Epub 2011 Aug 30.

PMID:
21912715
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

In vitro and in vivo high-throughput assays for the testing of anti-Trypanosoma cruzi compounds.

Canavaci AM, Bustamante JM, Padilla AM, Perez Brandan CM, Simpson LJ, Xu D, Boehlke CL, Tarleton RL.

PLoS Negl Trop Dis. 2010 Jul 13;4(7):e740. doi: 10.1371/journal.pntd.0000740.

PMID:
20644616
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.

dos Santos Filho JM, Moreira DR, de Simone CA, Ferreira RS, McKerrow JH, Meira CS, Guimarães ET, Soares MB.

Bioorg Med Chem. 2012 Nov 1;20(21):6423-33. doi: 10.1016/j.bmc.2012.08.047. Epub 2012 Aug 31.

PMID:
23006639
[PubMed - indexed for MEDLINE]
4.

Identification of three classes of heteroaromatic compounds with activity against intracellular Trypanosoma cruzi by chemical library screening.

Bettiol E, Samanovic M, Murkin AS, Raper J, Buckner F, Rodriguez A.

PLoS Negl Trop Dis. 2009;3(2):e384. doi: 10.1371/journal.pntd.0000384. Epub 2009 Feb 24.

PMID:
19238193
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.

Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS.

Antimicrob Agents Chemother. 2010 Aug;54(8):3326-34. doi: 10.1128/AAC.01777-09. Epub 2010 Jun 14.

PMID:
20547819
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

In vitro and in vivo trypanocidal activity of native plants from the Yucatan Peninsula.

Polanco-Hernández G, Escalante-Erosa F, García-Sosa K, Acosta-Viana K, Chan-Bacab MJ, Sagua-Franco H, González J, Osorio-Rodríguez L, Moo-Puc RE, Peña-Rodríguez LM.

Parasitol Res. 2012 Jan;110(1):31-5. doi: 10.1007/s00436-011-2447-8. Epub 2011 May 17.

PMID:
21584629
[PubMed - indexed for MEDLINE]
7.

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR.

PLoS Negl Trop Dis. 2010 Sep 14;4(9). pii: e825. doi: 10.1371/journal.pntd.0000825.

PMID:
20856868
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Antimicrobial peptides isolated from Phyllomedusa nordestina (Amphibia) alter the permeability of plasma membrane of Leishmania and Trypanosoma cruzi.

Pinto EG, Pimenta DC, Antoniazzi MM, Jared C, Tempone AG.

Exp Parasitol. 2013 Dec;135(4):655-60. doi: 10.1016/j.exppara.2013.09.016. Epub 2013 Oct 8.

PMID:
24113627
[PubMed - indexed for MEDLINE]
9.

In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi.

Díaz-Chiguer DL, Márquez-Navarro A, Nogueda-Torres B, de la Luz León-Ávila G, Pérez-Villanueva J, Hernández-Campos A, Castillo R, Ambrosio JR, Nieto-Meneses R, Yépez-Mulia L, Hernández-Luis F.

Acta Trop. 2012 Apr;122(1):108-12. doi: 10.1016/j.actatropica.2011.12.009. Epub 2011 Dec 27.

PMID:
22212465
[PubMed - indexed for MEDLINE]
10.

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi.

Keenan M, Alexander PW, Chaplin JH, Abbott MJ, Diao H, Wang Z, Best WM, Perez CJ, Cornwall SM, Keatley SK, Thompson RC, Charman SA, White KL, Ryan E, Chen G, Ioset JR, von Geldern TW, Chatelain E.

Future Med Chem. 2013 Oct;5(15):1733-52. doi: 10.4155/fmc.13.139.

PMID:
24144410
[PubMed - indexed for MEDLINE]
Free Article
11.

Biological, ultrastructural effect and subcellular localization of aromatic diamidines in Trypanosoma cruzi.

Batista DG, Pacheco MG, Kumar A, Branowska D, Ismail MA, Hu L, Boykin DW, Soeiro MN.

Parasitology. 2010 Feb;137(2):251-9. doi: 10.1017/S0031182009991223. Epub 2009 Sep 21.

PMID:
19765349
[PubMed - indexed for MEDLINE]
12.

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.

Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM.

PLoS Negl Trop Dis. 2012;6(7):e1736. doi: 10.1371/journal.pntd.0001736. Epub 2012 Jul 31.

PMID:
22860142
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

New thiadiazine derivatives with activity against Trypanosoma cruzi amastigotes.

Muelas S, Di Maio R, Cerecetto H, Seoane G, Ochoa C, Escario JA, Gómez-Barrio A.

Folia Parasitol (Praha). 2001;48(2):105-8.

PMID:
11437122
[PubMed - indexed for MEDLINE]
14.

Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action.

Vieites M, Smircich P, Guggeri L, Marchán E, Gómez-Barrio A, Navarro M, Garat B, Gambino D.

J Inorg Biochem. 2009 Oct;103(10):1300-6. doi: 10.1016/j.jinorgbio.2009.02.011. Epub 2009 Mar 17.

PMID:
19361864
[PubMed - indexed for MEDLINE]
15.

Antiprotozoal activity of 1-phenethyl-4-aminopiperidine derivatives.

Dardonville C, Fernández-Fernández C, Gibbons SL, Jagerovic N, Nieto L, Ryan G, Kaiser M, Brun R.

Antimicrob Agents Chemother. 2009 Sep;53(9):3815-21. doi: 10.1128/AAC.00124-09. Epub 2009 Jun 29.

PMID:
19564359
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

In vitro and in vivo investigation of the efficacy of arylimidamide DB1831 and its mesylated salt form--DB1965--against Trypanosoma cruzi infection.

da Silva CF, Batista Dda G, Oliveira GM, de Souza EM, Hammer ER, da Silva PB, Daliry A, Araujo JS, Britto C, Rodrigues AC, Liu Z, Farahat AA, Kumar A, Boykin DW, Soeiro Mde N.

PLoS One. 2012;7(1):e30356. doi: 10.1371/journal.pone.0030356. Epub 2012 Jan 23.

PMID:
22291940
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.

Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM.

Antimicrob Agents Chemother. 2010 Jun;54(6):2480-8. doi: 10.1128/AAC.00281-10. Epub 2010 Apr 12.

PMID:
20385875
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM.

PLoS Negl Trop Dis. 2009;3(2):e372. doi: 10.1371/journal.pntd.0000372. Epub 2009 Feb 3.

PMID:
19190730
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of Chagas disease.

Keenan M, Abbott MJ, Alexander PW, Armstrong T, Best WM, Berven B, Botero A, Chaplin JH, Charman SA, Chatelain E, von Geldern TW, Kerfoot M, Khong A, Nguyen T, McManus JD, Morizzi J, Ryan E, Scandale I, Thompson RA, Wang SZ, White KL.

J Med Chem. 2012 May 10;55(9):4189-204. doi: 10.1021/jm2015809. Epub 2012 Apr 27.

PMID:
22536986
[PubMed - indexed for MEDLINE]
20.

Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro/in vivo trypanocidal activity.

Silva JJ, Guedes PM, Zottis A, Balliano TL, Nascimento Silva FO, França Lopes LG, Ellena J, Oliva G, Andricopulo AD, Franco DW, Silva JS.

Br J Pharmacol. 2010 May;160(2):260-9. doi: 10.1111/j.1476-5381.2009.00524.x. Epub 2010 Jan 26.

PMID:
20105182
[PubMed - indexed for MEDLINE]
Free PMC Article

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