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Results: 1 to 20 of 109

Similar articles for PubMed (Select 21908613)

1.
2.

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).

García-Martínez JM, Alessi DR.

Biochem J. 2008 Dec 15;416(3):375-85. doi: 10.1042/BJ20081668.

PMID:
18925875
3.

Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate.

Gan X, Wang J, Su B, Wu D.

J Biol Chem. 2011 Apr 1;286(13):10998-1002. doi: 10.1074/jbc.M110.195016. Epub 2011 Feb 10.

4.

Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D.

J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8.

5.

The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.

Chen CH, Sarbassov dos D.

J Biol Chem. 2011 Nov 18;286(46):40386-94. doi: 10.1074/jbc.M111.282590. Epub 2011 Sep 30.

6.

IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.

Guo JP, Coppola D, Cheng JQ.

J Biol Chem. 2011 Oct 28;286(43):37389-98. doi: 10.1074/jbc.M111.287433. Epub 2011 Sep 9.

7.

Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2.

Boulbes D, Chen CH, Shaikenov T, Agarwal NK, Peterson TR, Addona TA, Keshishian H, Carr SA, Magnuson MA, Sabatini DM, Sarbassov dos D.

Mol Cancer Res. 2010 Jun;8(6):896-906. doi: 10.1158/1541-7786.MCR-09-0409. Epub 2010 May 25.

8.

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.

Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR.

Biochem J. 2011 May 15;436(1):169-79. doi: 10.1042/BJ20102103.

PMID:
21413931
9.

mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.

Wu YT, Ouyang W, Lazorchak AS, Liu D, Shen HM, Su B.

J Biol Chem. 2011 Apr 22;286(16):14190-8. doi: 10.1074/jbc.M111.219923. Epub 2011 Feb 14.

10.

IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.

Xie X, Zhang D, Zhao B, Lu MK, You M, Condorelli G, Wang CY, Guan KL.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6474-9. doi: 10.1073/pnas.1016132108. Epub 2011 Apr 4.

11.

Mechanical regulation of glycogen synthase kinase 3β (GSK3β) in mesenchymal stem cells is dependent on Akt protein serine 473 phosphorylation via mTORC2 protein.

Case N, Thomas J, Sen B, Styner M, Xie Z, Galior K, Rubin J.

J Biol Chem. 2011 Nov 11;286(45):39450-6. doi: 10.1074/jbc.M111.265330. Epub 2011 Sep 28.

12.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.

Tu Y, Ji C, Yang B, Yang Z, Gu H, Lu CC, Wang R, Su ZL, Chen B, Sun WL, Xia JP, Bi ZG, He L.

Mol Cancer. 2013 Dec 24;12(1):172. doi: 10.1186/1476-4598-12-172.

13.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

14.

mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].

Moore SF, Hunter RW, Hers I.

J Biol Chem. 2011 Jul 15;286(28):24553-60. doi: 10.1074/jbc.M110.202341. Epub 2011 May 18. Erratum in: J Biol Chem. 2011 Sep 2;286(35):31062.

15.

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.

Cell. 2006 Oct 6;127(1):125-37. Epub 2006 Sep 7.

16.

Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.

Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B.

Mol Cell. 2010 Aug 13;39(3):433-43. doi: 10.1016/j.molcel.2010.07.031.

17.

Amino acids activate mammalian target of rapamycin complex 2 (mTORC2) via PI3K/Akt signaling.

Tato I, Bartrons R, Ventura F, Rosa JL.

J Biol Chem. 2011 Feb 25;286(8):6128-42. doi: 10.1074/jbc.M110.166991. Epub 2010 Dec 3.

18.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.

Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27.

19.

Endoplasmic reticulum is a main localization site of mTORC2.

Boulbés DR, Shaiken T, Sarbassov dos D.

Biochem Biophys Res Commun. 2011 Sep 16;413(1):46-52. doi: 10.1016/j.bbrc.2011.08.034. Epub 2011 Aug 16.

20.

Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2.

Yuan M, Pino E, Wu L, Kacergis M, Soukas AA.

J Biol Chem. 2012 Aug 24;287(35):29579-88. doi: 10.1074/jbc.M112.386854. Epub 2012 Jul 7.

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