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Items: 1 to 20 of 106

1.

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans.

Lazzarato L, Cena C, Rolando B, Marini E, Lolli ML, Guglielmo S, Guaita E, Morini G, Coruzzi G, Fruttero R, Gasco A.

Bioorg Med Chem. 2011 Oct 1;19(19):5852-60. doi: 10.1016/j.bmc.2011.08.018. Epub 2011 Aug 16.

PMID:
21906954
2.

Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid.

Lazzarato L, Donnola M, Rolando B, Marini E, Cena C, Coruzzi G, Guaita E, Morini G, Fruttero R, Gasco A, Biondi S, Ongini E.

J Med Chem. 2008 Mar 27;51(6):1894-903. doi: 10.1021/jm701104f. Epub 2008 Feb 23.

PMID:
18293898
3.

Nitrooxyacyl derivatives of salicylic acid: aspirin-like molecules that covalently inactivate cyclooxygenase-1.

Cena C, Tosco P, Marini E, Lazzarato L, Piccinini M, Ramondetti C, Lupino E, Fruttero R, Gasco A.

ChemMedChem. 2011 Mar 7;6(3):523-30. doi: 10.1002/cmdc.201000397. Epub 2011 Jan 5.

PMID:
21360823
4.

The furoxan system: design of selective nitric oxide (NO) donor inhibitors of COX-2 endowed with anti-aggregatory and vasodilating activities.

Del Grosso E, Boschi D, Lazzarato L, Cena C, Di Stilo A, Fruttero R, Moro S, Gasco A.

Chem Biodivers. 2005 Jul;2(7):886-900.

PMID:
17193179
5.

Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization.

Boschi D, Cena C, Di Stilo A, Rolando B, Manzini P, Fruttero R, Gasco A.

Chem Biodivers. 2010 May;7(5):1173-82. doi: 10.1002/cbdv.200900421.

PMID:
20491074
6.

Water-soluble nitric-oxide-releasing acetylsalicylic acid (ASA) prodrugs.

Rolando B, Lazzarato L, Donnola M, Marini E, Joseph S, Morini G, Pozzoli C, Fruttero R, Gasco A.

ChemMedChem. 2013 Jul;8(7):1199-209. doi: 10.1002/cmdc.201300105. Epub 2013 Jun 10.

PMID:
23754790
7.

[Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates].

Zhou Z, Jiang LY, Zhang YH, Ji H, Sun Y, Peng SX.

Yao Xue Xue Bao. 2006 Nov;41(11):1050-6. Chinese.

PMID:
17262946
8.

(Nitrooxyacyloxy)methyl esters of aspirin as novel nitric oxide releasing aspirins.

Lazzarato L, Donnola M, Rolando B, Chegaev K, Marini E, Cena C, Di Stilo A, Fruttero R, Biondi S, Ongini E, Gasco A.

J Med Chem. 2009 Aug 27;52(16):5058-68. doi: 10.1021/jm900587h.

PMID:
20560642
9.

Mechanism of action of novel NO-releasing furoxan derivatives of aspirin in human platelets.

Turnbull CM, Cena C, Fruttero R, Gasco A, Rossi AG, Megson IL.

Br J Pharmacol. 2006 Jun;148(4):517-26. Epub 2006 May 15.

10.

A new class of ibuprofen derivatives with reduced gastrotoxicity.

Lolli ML, Cena C, Medana C, Lazzarato L, Morini G, Coruzzi G, Manarini S, Fruttero R, Gasco A.

J Med Chem. 2001 Oct 11;44(21):3463-8.

PMID:
11585451
11.

Nitric oxide donor beta2-agonists: furoxan derivatives containing the fenoterol moiety and related furazans.

Buonsanti MF, Bertinaria M, Stilo AD, Cena C, Fruttero R, Gasco A.

J Med Chem. 2007 Oct 4;50(20):5003-11. Epub 2007 Sep 11.

PMID:
17845020
12.

New nitric oxide or hydrogen sulfide releasing aspirins.

Lazzarato L, Chegaev K, Marini E, Rolando B, Borretto E, Guglielmo S, Joseph S, Di Stilo A, Fruttero R, Gasco A.

J Med Chem. 2011 Aug 11;54(15):5478-84. doi: 10.1021/jm2004514. Epub 2011 Jul 6.

PMID:
21688846
13.

A new class of furoxan derivatives as NO donors: mechanism of action and biological activity.

Ferioli R, Folco GC, Ferretti C, Gasco AM, Medana C, Fruttero R, Civelli M, Gasco A.

Br J Pharmacol. 1995 Feb;114(4):816-20.

14.

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin.

Cena C, Lolli ML, Lazzarato L, Guaita E, Morini G, Coruzzi G, McElroy SP, Megson IL, Fruttero R, Gasco A.

J Med Chem. 2003 Feb 27;46(5):747-54.

PMID:
12593655
15.

4-Methyl-3-(arylsulfonyl)furoxans: a new class of potent inhibitors of platelet aggregation.

Calvino R, Fruttero R, Ghigo D, Bosia A, Pescarmona GP, Gasco A.

J Med Chem. 1992 Aug 21;35(17):3296-300.

PMID:
1324320
16.

Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.

El-Sayed MA, Abdel-Aziz NI, Abdel-Aziz AA, El-Azab AS, Asiri YA, Eltahir KE.

Bioorg Med Chem. 2011 Jun 1;19(11):3416-24. doi: 10.1016/j.bmc.2011.04.027. Epub 2011 Apr 22.

PMID:
21570309
17.

Synthesis and pharmacological evaluation of 2,5-cycloamino-5H-[1]benzopyrano[4,3-d]pyrimidines endowed with in vitro antiplatelet activity.

Bruno O, Brullo C, Ranise A, Schenone S, Bondavalli F, Barocelli E, Ballabeni V, Chiavarini M, Tognolini M, Impicciatore M.

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1397-400.

PMID:
11378363
18.

NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties.

Chegaev K, Lazzarato L, Tosco P, Cena C, Marini E, Rolando B, Carrupt PA, Fruttero R, Gasco A.

J Med Chem. 2007 Apr 5;50(7):1449-57. Epub 2007 Mar 3.

PMID:
17335184
19.

Structure, stability, and antiplatelet activity of O-acyl derivatives of salicylic acid and lipophilic esters of acetylsalicylate.

Zavodnik IB, Lapshina E, Sudnikovich E, Boncler M, Luzak B, Rózalski M, Helińska M, Watała C.

Pharmacol Rep. 2009 May-Jun;61(3):476-89.

20.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.

Abdellatif KR, Chowdhury MA, Dong Y, Das D, Yu G, Velázquez C, Suresh MR, Knaus EE.

Bioorg Med Chem. 2009 Jul 15;17(14):5182-8. doi: 10.1016/j.bmc.2009.05.046. Epub 2009 May 27.

PMID:
19500994
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