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Results: 1 to 20 of 94

1.

Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation.

Vohwinkel CU, Lecuona E, Sun H, Sommer N, Vadász I, Chandel NS, Sznajder JI.

J Biol Chem. 2011 Oct 28;286(43):37067-76. doi: 10.1074/jbc.M111.290056. Epub 2011 Sep 8.

PMID:
21903582
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

MicroRNA-183 upregulates HIF-1α by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells.

Tanaka H, Sasayama T, Tanaka K, Nakamizo S, Nishihara M, Mizukawa K, Kohta M, Koyama J, Miyake S, Taniguchi M, Hosoda K, Kohmura E.

J Neurooncol. 2013 Feb;111(3):273-83. doi: 10.1007/s11060-012-1027-9. Epub 2012 Dec 23.

PMID:
23263745
[PubMed - indexed for MEDLINE]
3.

Effects of hypoxia and hypercapnia on surfactant protein expression proliferation and apoptosis in A549 alveolar epithelial cells.

Vaporidi K, Tsatsanis C, Georgopoulos D, Tsichlis PN.

Life Sci. 2005 Dec 5;78(3):284-93. Epub 2005 Aug 26.

PMID:
16125734
[PubMed - indexed for MEDLINE]
4.

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability.

Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19611-6. doi: 10.1073/pnas.1117773108. Epub 2011 Nov 21.

PMID:
22106302
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat.

Kantores C, McNamara PJ, Teixeira L, Engelberts D, Murthy P, Kavanagh BP, Jankov RP.

Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L912-22. Epub 2006 Jul 7.

PMID:
16829630
[PubMed - indexed for MEDLINE]
Free Article
6.

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.

Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, Cross JR, Fantin VR, Hedvat CV, Perl AE, Rabinowitz JD, Carroll M, Su SM, Sharp KA, Levine RL, Thompson CB.

Cancer Cell. 2010 Mar 16;17(3):225-34. doi: 10.1016/j.ccr.2010.01.020. Epub 2010 Feb 18.

PMID:
20171147
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144.

Fu X, Huang X, Li P, Chen W, Xia M.

Free Radic Biol Med. 2014 Jun;71:1-15. doi: 10.1016/j.freeradbiomed.2014.03.010. Epub 2014 Mar 15.

PMID:
24642088
[PubMed - in process]
8.

Hypercapnia induces cleavage and nuclear localization of RelB protein, giving insight into CO2 sensing and signaling.

Oliver KM, Lenihan CR, Bruning U, Cheong A, Laffey JG, McLoughlin P, Taylor CT, Cummins EP.

J Biol Chem. 2012 Apr 20;287(17):14004-11. doi: 10.1074/jbc.M112.347971. Epub 2012 Mar 6.

PMID:
22396550
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status.

Yu W, Dittenhafer-Reed KE, Denu JM.

J Biol Chem. 2012 Apr 20;287(17):14078-86. doi: 10.1074/jbc.M112.355206. Epub 2012 Mar 13.

PMID:
22416140
[PubMed - indexed for MEDLINE]
Free PMC Article
10.
11.

Chronic hypercapnia downregulates arginase expression and activity and increases pulmonary arterial smooth muscle relaxation in the newborn rat.

Belik J, Stevens D, Pan J, Shehnaz D, Ibrahim C, Kantores C, Ivanovska J, Grasemann H, Jankov RP.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L777-84. doi: 10.1152/ajplung.00047.2009. Epub 2009 Aug 7.

PMID:
19666777
[PubMed - indexed for MEDLINE]
Free Article
12.

Pathway of carbon flow during fatty acid synthesis from lactate and pyruvate in rat adipose tissue.

Patel MS, Jomain-Baum M, Ballard FJ, Hanson RW.

J Lipid Res. 1971 Mar;12(2):179-91.

PMID:
4396562
[PubMed - indexed for MEDLINE]
Free Article
13.

Matrix metalloproteinase (MMP)-1 induces lung alveolar epithelial cell migration and proliferation, protects from apoptosis, and represses mitochondrial oxygen consumption.

Herrera I, Cisneros J, Maldonado M, Ramírez R, Ortiz-Quintero B, Anso E, Chandel NS, Selman M, Pardo A.

J Biol Chem. 2013 Sep 6;288(36):25964-75. doi: 10.1074/jbc.M113.459784. Epub 2013 Jul 31.

PMID:
23902766
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Effect of hypercapnia on intracellular pH regulation in a rainbow trout hepatoma cell line, RTH 149.

Huynh KT, Baker DW, Harris R, Church J, Brauner CJ.

J Comp Physiol B. 2011 Oct;181(7):883-92. doi: 10.1007/s00360-011-0583-1. Epub 2011 May 3.

PMID:
21538070
[PubMed - indexed for MEDLINE]
15.

AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.

Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI.

J Clin Invest. 2008 Feb;118(2):752-62. doi: 10.1172/JCI29723.

PMID:
18188452
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity.

Puisségur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, Maurin T, Lebrigand K, Cardinaud B, Hofman V, Fourre S, Magnone V, Ricci JE, Pouysségur J, Gounon P, Hofman P, Barbry P, Mari B.

Cell Death Differ. 2011 Mar;18(3):465-78. doi: 10.1038/cdd.2010.119. Epub 2010 Oct 1.

PMID:
20885442
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Therapeutic hypercapnia prevents bleomycin-induced pulmonary hypertension in neonatal rats by limiting macrophage-derived tumor necrosis factor-α.

Sewing AC, Kantores C, Ivanovska J, Lee AH, Masood A, Jain A, McNamara PJ, Tanswell AK, Jankov RP.

Am J Physiol Lung Cell Mol Physiol. 2012 Jul 1;303(1):L75-87. doi: 10.1152/ajplung.00072.2012. Epub 2012 May 11.

PMID:
22582114
[PubMed - indexed for MEDLINE]
Free Article
18.

Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.

Douglas RM, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan LL, Haddad GG, Ali SS.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1594-602. doi: 10.1152/ajpcell.00298.2009. Epub 2010 Mar 31.

PMID:
20357179
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells.

Feng S, Cong S, Zhang X, Bao X, Wang W, Li H, Wang Z, Wang G, Xu J, Du B, Qu D, Xiong W, Yin M, Ren X, Wang F, He J, Zhang B.

Nucleic Acids Res. 2011 Aug;39(15):6669-78. doi: 10.1093/nar/gkr232. Epub 2011 Apr 21.

PMID:
21511813
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

Ward PS, Lu C, Cross JR, Abdel-Wahab O, Levine RL, Schwartz GK, Thompson CB.

J Biol Chem. 2013 Feb 8;288(6):3804-15. doi: 10.1074/jbc.M112.435495. Epub 2012 Dec 21.

PMID:
23264629
[PubMed - indexed for MEDLINE]
Free PMC Article

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