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Results: 1 to 20 of 129

1.

Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs.

Wan S, Wu F, Rech JC, Green ME, Balachandran R, Horne WS, Day BW, Floreancig PE.

J Am Chem Soc. 2011 Oct 19;133(41):16668-79. doi: 10.1021/ja207331m. Epub 2011 Sep 22.

PMID:
21902245
[PubMed - indexed for MEDLINE]
2.

Synthesis of psymberin analogues: probing a functional correlation with the pederin/mycalamide family of natural products.

Jiang X, Williams N, De Brabander JK.

Org Lett. 2007 Jan 18;9(2):227-30.

PMID:
17217271
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The discovery of potent antitumor agent C11-deoxypsymberin/irciniastatin A: total synthesis and biology of advanced psymberin analogs.

Huang X, Shao N, Huryk R, Palani A, Aslanian R, Seidel-Dugan C.

Org Lett. 2009 Feb 19;11(4):867-70. doi: 10.1021/ol802772s.

PMID:
19199777
[PubMed - indexed for MEDLINE]
4.

Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family.

Cichewicz RH, Valeriote FA, Crews P.

Org Lett. 2004 Jun 10;6(12):1951-4.

PMID:
15176791
[PubMed - indexed for MEDLINE]
5.

Studies toward the unique pederin family member psymberin: full structure elucidation, two alternative total syntheses, and analogs.

Feng Y, Jiang X, De Brabander JK.

J Am Chem Soc. 2012 Oct 17;134(41):17083-93. doi: 10.1021/ja3057612. Epub 2012 Oct 4.

PMID:
23004238
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Synthesis and complete stereochemical assignment of psymberin/irciniastatin A.

Jiang X, García-Fortanet J, De Brabander JK.

J Am Chem Soc. 2005 Aug 17;127(32):11254-5.

PMID:
16089449
[PubMed - indexed for MEDLINE]
7.

Isolation, biological activity, synthesis, and medicinal chemistry of the pederin/mycalamide family of natural products.

Mosey RA, Floreancig PE.

Nat Prod Rep. 2012 Sep;29(9):980-95. doi: 10.1039/c2np20052j. Epub 2012 Jul 9. Review.

PMID:
22772477
[PubMed - indexed for MEDLINE]
8.

Concise and stereoselective synthesis of the N7-C25 fragment of psymberin.

Rech JC, Floreancig PE.

Org Lett. 2005 Nov 10;7(23):5175-8.

PMID:
16268531
[PubMed - indexed for MEDLINE]
9.

The total synthesis of psymberin.

Huang X, Shao N, Palani A, Aslanian R, Buevich A.

Org Lett. 2007 Jun 21;9(13):2597-600. Epub 2007 May 25.

PMID:
17523653
[PubMed - indexed for MEDLINE]
10.

Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules.

Marco JA, García-Pla J, Carda M, Murga J, Falomir E, Trigili C, Notararigo S, Díaz JF, Barasoain I.

Eur J Med Chem. 2011 May;46(5):1630-7. doi: 10.1016/j.ejmech.2011.02.011. Epub 2011 Feb 22.

PMID:
21396747
[PubMed - indexed for MEDLINE]
11.

Mycalamides, pederin and psymberin as natural carbohydrates and potential antitumor agents: past and future perspectives.

Witczak ZJ, Rampulla RM, Bommareddy A.

Mini Rev Med Chem. 2012 Dec;12(14):1520-32. Review.

PMID:
22827176
[PubMed - indexed for MEDLINE]
12.

Synthesis of a 35-member stereoisomer library of bistramide A: evaluation of effects on actin state, cell cycle and tumor cell growth.

Wrona IE, Lowe JT, Turbyville TJ, Johnson TR, Beignet J, Beutler JA, Panek JS.

J Org Chem. 2009 Mar 6;74(5):1897-916. doi: 10.1021/jo802269q.

PMID:
19191575
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Design and synthesis of novel tetrahydro-2H-Pyrano[3,2-c]pyridazin-3(6H)-one derivatives as potential anticancer agents.

Al-Tel TH.

Eur J Med Chem. 2010 Dec;45(12):5724-31. doi: 10.1016/j.ejmech.2010.09.029. Epub 2010 Sep 17.

PMID:
20884086
[PubMed - indexed for MEDLINE]
14.

Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT).

Judd WR, Slattum PM, Hoang KC, Bhoite L, Valppu L, Alberts G, Brown B, Roth B, Ostanin K, Huang L, Wettstein D, Richards B, Willardsen JA.

J Med Chem. 2011 Jul 28;54(14):5031-47. doi: 10.1021/jm200249a. Epub 2011 Jun 28.

PMID:
21661760
[PubMed - indexed for MEDLINE]
15.

Probing the bioactive constituents from chemotypes of the sponge Psammocinia aff. bulbosa.

Robinson SJ, Tenney K, Yee DF, Martinez L, Media JE, Valeriote FA, van Soest RW, Crews P.

J Nat Prod. 2007 Jun;70(6):1002-9. Epub 2007 Jun 9. Erratum in: J Nat Prod. 2007 Oct;70(10):1690.

PMID:
17559267
[PubMed - indexed for MEDLINE]
16.

Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs.

Al-Obaid AM, Abdel-Hamide SG, El-Kashef HA, Abdel-Aziz AA, El-Azab AS, Al-Khamees HA, El-Subbagh HI.

Eur J Med Chem. 2009 Jun;44(6):2379-91. doi: 10.1016/j.ejmech.2008.09.015. Epub 2008 Sep 23.

PMID:
18950904
[PubMed - indexed for MEDLINE]
17.

Synthesis and biological evaluation of neopeltolide and analogs.

Cui Y, Balachandran R, Day BW, Floreancig PE.

J Org Chem. 2012 Mar 2;77(5):2225-35. doi: 10.1021/jo2023685. Epub 2012 Feb 22.

PMID:
22329423
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

2-pyrones possessing antimicrobial and cytotoxic activities.

Fairlamb IJ, Marrison LR, Dickinson JM, Lu FJ, Schmidt JP.

Bioorg Med Chem. 2004 Aug 1;12(15):4285-99.

PMID:
15246105
[PubMed - indexed for MEDLINE]
19.

Cryptocaryols A and B: total syntheses, stereochemical revision, structure elucidation, and structure-activity relationship.

Wang Y, O'Doherty GA.

J Am Chem Soc. 2013 Jun 26;135(25):9334-7. doi: 10.1021/ja404401f. Epub 2013 Jun 14.

PMID:
23750754
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport.

Xiao X, Wu J, Trigili C, Chen H, Chu JW, Zhao Y, Lu P, Sheng L, Li Y, Sharom FJ, Barasoain I, Diaz JF, Fang WS.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4852-6. doi: 10.1016/j.bmcl.2011.06.034. Epub 2011 Jun 17.

PMID:
21764308
[PubMed - indexed for MEDLINE]
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