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Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice.

Kyrkanides S, Tallents RH, Miller JN, Olschowka ME, Johnson R, Yang M, Olschowka JA, Brouxhon SM, O'Banion MK.

J Neuroinflammation. 2011 Sep 7;8:112. doi: 10.1186/1742-2094-8-112.


Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.

Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O'Banion MK.

J Neuroimmune Pharmacol. 2012 Mar;7(1):156-64. doi: 10.1007/s11481-011-9331-2. Epub 2011 Dec 16.


Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, LaFerla FM, Olschowka JA, O'Banion MK.

J Neurosci. 2013 Mar 13;33(11):5053-64. doi: 10.1523/JNEUROSCI.4361-12.2013.


The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease.

Collins JM, King AE, Woodhouse A, Kirkcaldie MT, Vickers JC.

Exp Neurol. 2015 May;267:219-29. doi: 10.1016/j.expneurol.2015.02.034. Epub 2015 Mar 4.


NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice.

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT.

Nature. 2013 Jan 31;493(7434):674-8. doi: 10.1038/nature11729. Epub 2012 Dec 19.


Quantitative proteomics reveals that PEA15 regulates astroglial Aβ phagocytosis in an Alzheimer's disease mouse model.

Lv J, Ma S, Zhang X, Zheng L, Ma Y, Zhao X, Lai W, Shen H, Wang Q, Ji J.

J Proteomics. 2014 Oct 14;110:45-58. doi: 10.1016/j.jprot.2014.07.028. Epub 2014 Aug 7.


IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease.

Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA.

J Immunol. 2013 Mar 1;190(5):2241-51. doi: 10.4049/jimmunol.1200947. Epub 2013 Jan 30.


Role of neuroinflammation in hypertension-induced brain amyloid pathology.

Carnevale D, Mascio G, Ajmone-Cat MA, D'Andrea I, Cifelli G, Madonna M, Cocozza G, Frati A, Carullo P, Carnevale L, Alleva E, Branchi I, Lembo G, Minghetti L.

Neurobiol Aging. 2012 Jan;33(1):205.e19-29. doi: 10.1016/j.neurobiolaging.2010.08.013. Epub 2010 Oct 18.


Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.

Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE.

Neurobiol Aging. 2009 Oct;30(10):1587-600. doi: 10.1016/j.neurobiolaging.2007.12.013. Epub 2008 Apr 10.


Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Aβ pathology and improves cognitive function.

Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL.

Exp Mol Med. 2012 Dec 31;44(12):740-8. doi: 10.3858/emm.2012.44.12.082.


APP/PS1 mice overexpressing SREBP-2 exhibit combined Aβ accumulation and tau pathology underlying Alzheimer's disease.

Barbero-Camps E, Fernández A, Martínez L, Fernández-Checa JC, Colell A.

Hum Mol Genet. 2013 Sep 1;22(17):3460-76. doi: 10.1093/hmg/ddt201. Epub 2013 May 6.


Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease.

Paris D, Ganey NJ, Laporte V, Patel NS, Beaulieu-Abdelahad D, Bachmeier C, March A, Ait-Ghezala G, Mullan MJ.

J Neuroinflammation. 2010 Mar 8;7:17. doi: 10.1186/1742-2094-7-17.


Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice.

McManus RM, Higgins SC, Mills KH, Lynch MA.

Neurobiol Aging. 2014 Jan;35(1):109-21. doi: 10.1016/j.neurobiolaging.2013.07.025. Epub 2013 Aug 29.


Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice.

Liu HL, Zhao G, Zhang H, Shi LD.

Behav Brain Res. 2013 Nov 1;256:261-72. doi: 10.1016/j.bbr.2013.08.008. Epub 2013 Aug 19.


Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

Rodriguez GA, Tai LM, LaDu MJ, Rebeck GW.

J Neuroinflammation. 2014 Jun 19;11:111. doi: 10.1186/1742-2094-11-111.


Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice.

Xie K, Liu Y, Hao W, Walter S, Penke B, Hartmann T, Schachner M, Fassbender K.

Neurobiol Aging. 2013 Oct;34(10):2389-98. doi: 10.1016/j.neurobiolaging.2013.04.013. Epub 2013 May 11.


Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer's disease.

Lok K, Zhao H, Zhang C, He N, Shen H, Wang Z, Zhao W, Yin M.

J Neurol Sci. 2013 Dec 15;335(1-2):145-54. doi: 10.1016/j.jns.2013.09.018. Epub 2013 Sep 21.


Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease.

Tweedie D, Ferguson RA, Fishman K, Frankola KA, Van Praag H, Holloway HW, Luo W, Li Y, Caracciolo L, Russo I, Barlati S, Ray B, Lahiri DK, Bosetti F, Greig NH, Rosi S.

J Neuroinflammation. 2012 May 29;9:106. doi: 10.1186/1742-2094-9-106.


Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, Tran T, Ubeda O, Ashe KH, Frautschy SA, Cole GM.

J Neurosci. 2000 Aug 1;20(15):5709-14.


RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.

Fang F, Lue LF, Yan S, Xu H, Luddy JS, Chen D, Walker DG, Stern DM, Yan S, Schmidt AM, Chen JX, Yan SS.

FASEB J. 2010 Apr;24(4):1043-55. doi: 10.1096/fj.09-139634. Epub 2009 Nov 11.

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