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Items: 1 to 20 of 157

1.

Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: role of the Akt pathway and the ERK/Bim axis.

Matsumoto T, Nagase Y, Iwasawa M, Yasui T, Masuda H, Kadono Y, Nakamura K, Tanaka S.

Arthritis Rheum. 2011 Dec;63(12):3908-17. doi: 10.1002/art.30646.

2.

Involvement of Ras/extracellular signal-regulated kinase, but not Akt pathway in risedronate-induced apoptosis of U937 cells and its suppression by cytochalasin B.

Fujita H, Utsumi T, Muranaka S, Ogino T, Yano H, Akiyama J, Yasuda T, Utsumi K.

Biochem Pharmacol. 2005 Jun 15;69(12):1773-84.

PMID:
15869745
3.

AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways.

Kwak HB, Sun HM, Ha H, Lee JH, Kim HN, Lee ZH.

Mol Cells. 2008 Nov 30;26(5):436-42.

4.

Risedronate directly inhibits osteoclast differentiation and inflammatory bone loss.

Kwak HB, Kim JY, Kim KJ, Choi MK, Kim JJ, Kim KM, Shin YI, Lee MS, Kim HS, Kim JW, Chun CH, Cho HJ, Hong GY, Juhng SK, Yoon KH, Park BH, Bae JM, Han JK, Oh J.

Biol Pharm Bull. 2009 Jul;32(7):1193-8.

5.
6.

Regulation of osteoclast apoptosis and motility by small GTPase binding protein Rac1.

Fukuda A, Hikita A, Wakeyama H, Akiyama T, Oda H, Nakamura K, Tanaka S.

J Bone Miner Res. 2005 Dec;20(12):2245-53. Epub 2005 Aug 22.

7.

Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts.

Wakeyama H, Akiyama T, Takahashi K, Amano H, Kadono Y, Nakamura M, Oshima Y, Itabe H, Nakayama KI, Nakayama K, Nakamura K, Tanaka S.

J Bone Miner Res. 2007 Oct;22(10):1631-9.

8.

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

Luckman SP, Hughes DE, Coxon FP, Graham R, Russell G, Rogers MJ.

J Bone Miner Res. 1998 Apr;13(4):581-9.

9.

Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo.

Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD, Mundy GR, Boyce BF.

J Bone Miner Res. 1995 Oct;10(10):1478-87.

PMID:
8686503
10.

Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells.

Abutin RM, Chen J, Lung TK, Lloyd JA, Sawyer ST, Harada H.

Exp Hematol. 2009 Feb;37(2):151-8. doi: 10.1016/j.exphem.2008.10.008. Epub 2008 Dec 18.

13.

GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway.

Lee MS, Kim HS, Yeon JT, Choi SW, Chun CH, Kwak HB, Oh J.

J Immunol. 2009 Sep 1;183(5):3390-9. doi: 10.4049/jimmunol.0804314. Epub 2009 Jul 29.

14.

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis.

Halasy-Nagy JM, Rodan GA, Reszka AA.

Bone. 2001 Dec;29(6):553-9.

PMID:
11728926
15.

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung UI, Fukuda A, Hikita A, Seto H, Okada T, Inaba T, Sanjay A, Baron R, Kawaguchi H, Oda H, Nakamura K, Strasser A, Tanaka S.

EMBO J. 2003 Dec 15;22(24):6653-64.

16.

Transforming growth factor-beta1 (TGF-beta1) induces human osteoclast apoptosis by up-regulating Bim.

Houde N, Chamoux E, Bisson M, Roux S.

J Biol Chem. 2009 Aug 28;284(35):23397-404. doi: 10.1074/jbc.M109.019372. Epub 2009 Jul 1.

17.

The proapoptotic Bcl-2 family member Bim plays a central role during the development of virus-induced hepatitis.

Lauer C, Brunner T, Corazza N.

J Immunol. 2012 Jan 15;188(2):916-22. doi: 10.4049/jimmunol.1101864. Epub 2011 Dec 7.

18.

Breast cancer cells inhibit spontaneous and bisphosphonate-induced osteoclast apoptosis.

Hussein O, Tiedemann K, Komarova SV.

Bone. 2011 Feb;48(2):202-11. doi: 10.1016/j.bone.2010.09.006. Epub 2010 Sep 21.

PMID:
20849994
19.

The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells.

Greenhough A, Wallam CA, Hicks DJ, Moorghen M, Williams AC, Paraskeva C.

Oncogene. 2010 Jun 10;29(23):3398-410. doi: 10.1038/onc.2010.94. Epub 2010 Mar 29.

20.

Calcitonin inhibits SDCP-induced osteoclast apoptosis and increases its efficacy in a rat model of osteoporosis.

Kuo YJ, Tsuang FY, Sun JS, Lin CH, Chen CH, Li JY, Huang YC, Chen WY, Yeh CB, Shyu JF.

PLoS One. 2012;7(7):e40272. doi: 10.1371/journal.pone.0040272. Epub 2012 Jul 6.

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