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Results: 1 to 20 of 90

1.

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.

Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT.

Cell. 2011 Sep 2;146(5):697-708. doi: 10.1016/j.cell.2011.07.032. Erratum in: Cell. 2011 Sep 30;147(1):247. Schöll, Claudia [corrected to Scholl, Claudia].

PMID:
21884932
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia.

Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A.

Nature. 2010 Feb 4;463(7281):676-80. doi: 10.1038/nature08734.

PMID:
20130650
[PubMed - indexed for MEDLINE]
3.

Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation.

Brandts CH, Sargin B, Rode M, Biermann C, Lindtner B, Schwäble J, Buerger H, Müller-Tidow C, Choudhary C, McMahon M, Berdel WE, Serve H.

Cancer Res. 2005 Nov 1;65(21):9643-50.

PMID:
16266983
[PubMed - indexed for MEDLINE]
Free Article
4.

Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias.

Zhao S, Konopleva M, Cabreira-Hansen M, Xie Z, Hu W, Milella M, Estrov Z, Mills GB, Andreeff M.

Leukemia. 2004 Feb;18(2):267-75.

PMID:
14628071
[PubMed - indexed for MEDLINE]
5.

Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways.

Gao N, Budhraja A, Cheng S, Liu EH, Chen J, Yang Z, Chen D, Zhang Z, Shi X.

Cell Death Dis. 2011 Apr 7;2:e140. doi: 10.1038/cddis.2011.22.

PMID:
21472003
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice.

Kharas MG, Okabe R, Ganis JJ, Gozo M, Khandan T, Paktinat M, Gilliland DG, Gritsman K.

Blood. 2010 Feb 18;115(7):1406-15. doi: 10.1182/blood-2009-06-229443. Epub 2009 Dec 14.

PMID:
20008787
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Downregulation of c-Jun expression and cell cycle regulatory molecules in acute myeloid leukemia cells upon CD44 ligation.

Zada AA, Singh SM, Reddy VA, Elsässer A, Meisel A, Haferlach T, Tenen DG, Hiddemann W, Behre G.

Oncogene. 2003 Apr 17;22(15):2296-308.

PMID:
12700665
[PubMed - indexed for MEDLINE]
8.

Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK.

Dai Y, Rahmani M, Pei XY, Khanna P, Han SI, Mitchell C, Dent P, Grant S.

Blood. 2005 Feb 15;105(4):1706-16. Epub 2004 Oct 19.

PMID:
15494423
[PubMed - indexed for MEDLINE]
Free Article
9.

IκB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia.

Chapuis N, Park S, Leotoing L, Tamburini J, Verdier F, Bardet V, Green AS, Willems L, Agou F, Ifrah N, Dreyfus F, Bismuth G, Baud V, Lacombe C, Mayeux P, Bouscary D.

Blood. 2010 Nov 18;116(20):4240-50. doi: 10.1182/blood-2009-12-260711. Epub 2010 Jul 29.

PMID:
20671123
[PubMed - indexed for MEDLINE]
Free Article
10.

Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts.

Tazzari PL, Cappellini A, Ricci F, Evangelisti C, Papa V, Grafone T, Martinelli G, Conte R, Cocco L, McCubrey JA, Martelli AM.

Leukemia. 2007 Mar;21(3):427-38. Epub 2007 Jan 11.

PMID:
17215852
[PubMed - indexed for MEDLINE]
11.

PI3K/Akt and MAPK pathways evoke activation of FoxO transcription factor to undergo neuronal apoptosis in brain of the silkworm Bombyx mori (Lepidoptera: Bombycidae).

Kim JH, Choi JS, Lee BH.

Cell Mol Biol (Noisy-le-grand). 2012 Oct 10;Suppl.58:OL1780-5.

PMID:
23046871
[PubMed - indexed for MEDLINE]
12.

Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.

Sunters A, Madureira PA, Pomeranz KM, Aubert M, Brosens JJ, Cook SJ, Burgering BM, Coombes RC, Lam EW.

Cancer Res. 2006 Jan 1;66(1):212-20.

PMID:
16397234
[PubMed - indexed for MEDLINE]
Free Article
13.

Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway.

Boreddy SR, Pramanik KC, Srivastava SK.

Clin Cancer Res. 2011 Apr 1;17(7):1784-95. doi: 10.1158/1078-0432.CCR-10-1891. Epub 2011 Feb 24. Erratum in: Clin Cancer Res. 2012 May 1;18(9):2719.

PMID:
21350002
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells.

Chen Q, Ganapathy S, Singh KP, Shankar S, Srivastava RK.

PLoS One. 2010 Dec 14;5(12):e15288. doi: 10.1371/journal.pone.0015288.

PMID:
21179458
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.

Roy SK, Chen Q, Fu J, Shankar S, Srivastava RK.

PLoS One. 2011;6(9):e25166. doi: 10.1371/journal.pone.0025166. Epub 2011 Sep 27.

PMID:
21980390
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells.

Ozpolat B, Akar U, Steiner M, Zorrilla-Calancha I, Tirado-Gomez M, Colburn N, Danilenko M, Kornblau S, Berestein GL.

Mol Cancer Res. 2007 Jan;5(1):95-108.

PMID:
17259349
[PubMed - indexed for MEDLINE]
Free Article
17.

3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.

Gao N, Cheng S, Budhraja A, Liu EH, Chen J, Chen D, Yang Z, Luo J, Shi X, Zhang Z.

PLoS One. 2012;7(2):e31783. doi: 10.1371/journal.pone.0031783. Epub 2012 Feb 21.

PMID:
22363731
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo.

Budhraja A, Gao N, Zhang Z, Son YO, Cheng S, Wang X, Ding S, Hitron A, Chen G, Luo J, Shi X.

Mol Cancer Ther. 2012 Jan;11(1):132-42. doi: 10.1158/1535-7163.MCT-11-0343. Epub 2011 Nov 14.

PMID:
22084167
[PubMed - indexed for MEDLINE]
Free Article
19.

Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway.

Doepfner KT, Spertini O, Arcaro A.

Leukemia. 2007 Sep;21(9):1921-30. Epub 2007 Jun 21.

PMID:
17581609
[PubMed - indexed for MEDLINE]
20.

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.

Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA.

Cell. 2007 Jan 26;128(2):309-23.

PMID:
17254969
[PubMed - indexed for MEDLINE]
Free PMC Article

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